Results 11 to 20 of about 84,306 (206)

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Protective effect of leukotriene receptor antagonist montelukast on smoking-induced lung injury in Wistar rats. [PDF]

, 2003
Increased activation of alveolar macrophage, neutrophil and mast cell has been proven in cigarette smoking (CS)-related lung disorders (CSLD). An increased production of cysteinyl-leukotrienes (LTs), which are mediators secreted from the mentioned cells,
Coskun, Senol, Ozbilgin, Kemal, Tuglu, Ibrahim, Yuksel, Hasan   +3 more
core   +1 more source

Integrating evidence for managing asthma in patients who smoke [PDF]

, 2014
Peer reviewedPublisher ...
Bjermer, Leif, Chisholm, Alison, Popov, Todor A, Price, David   +3 more
core   +1 more source

Circulating leukotriene b4 identifies respiratory complications after trauma [PDF]

, 2012
Background. Leukotriene B4 (LTB4), a proinflammatory lipid mediator correlates well with the acute phase of Acute Respiratory Distress Syndrome (ARDS). Therefore, LTB4-levels were investigated to determine whether they might be a useful clinical marker ...
Auner, Birgit, Geiger, Emanuel Valentin, Henrich, Dirk, Lehnert, Mark, Marzi, Ingo, Relja, Borna   +5 more
core   +1 more source

温泉療法による気管支喘息に対する年間薬剤費の削減 [PDF]

, 2004
Costs of drugs used for the treatment for 1 year were compared before and after spa therapy in 16 patients with asthma in relation to disease severity. Asthma severity was classified as : stage 1 (intermittent), 2 (mild persistent), 3(moderate persistent)
Ashida, Kozo, Fujii, Makoto, Hamada, Masanori, Hosaki, Yasuhiro, Iwagaki, Naofumi, Mitsunobu, Fumihiro, Takata, Shingo, Tanizaki, Yoshiro   +7 more
core   +1 more source

Virtual screening for NS5B inhibitors of Hepatitis C virus [PDF]

, 2012
Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at a risk of developing significant morbidity and mortality.
Achuthsankar S. Nair, Amjesh R, Sugunan V.S.   +2 more
core   +2 more sources

Phase 2 trial of montelukast for prevention of pain in sickle cell disease. [PDF]

, 2020
Cysteinyl leukotrienes (CysLTs) are lipid mediators of inflammation. In patients with sickle cell disease (SCD), levels of CysLTs are increased compared with controls and associated with a higher rate of hospitalization for pain. We tested the hypothesis
Brandow, Amanda, Bryant, Valencia, DeBaun, Michael R, Embury, Stephen H, Field, Joshua J, Kassim, Adetola, Matsui, Neil, Simpson, Pippa, Wilkerson, Karina, Zhang, Liyun   +9 more
core  

長期間喫煙による気管支唱息,肺気腫の病態的変化 [PDF]

, 2004
The influence of long-term cigarette smoking on the pathophysiology of chronic respiratory diseases with obstructive ventilatory dysfunction was discussed in patients with asthma and pulmonary emphysema (PE). 1.
Ashida, Kozo, Fujii, Makoto, Hamada, Masanori, Hosaki, Yasuhiro, Iwagaki, Naofumi, Mitsunobu, Fumihiro, Takata, Shingo, Tanizaki, Yoshiro   +7 more
core   +1 more source

Steroids in pediatric eosinophilic esophagitis [PDF]

, 2014
Swallowed fluticasone and oral viscous budesonide are effective first-line therapies for eosinophilic esophagitis in children. Side effects are minimal without evidence of Cushing syndrome, as seen in treatment with systemic corticosteroids.
Contreras, Emily M., Gupta, Sandeep K.
core   +1 more source