Results 121 to 130 of about 25,256 (244)

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

open access: yesEpilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar   +4 more
wiley   +1 more source

Salience network hub dysfunction is associated with cognitive impairment in self‐limited epilepsy with centrotemporal spikes: An OPM‐MEG study

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Self‐limited epilepsy with centrotemporal spikes (SeLECTS), although characterized by well‐controlled seizures, is frequently associated with persistent cognitive deficits in affected children. This study aimed to investigate whether hub dysfunction of the salience network (SN) is associated with cognitive impairment in SeLECTS ...
Chen Yang   +9 more
wiley   +1 more source

Auditory gamma‐band synchronization and attentional performance in juvenile myoclonic epilepsy

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Cognitive difficulties in juvenile myoclonic epilepsy (JME) are part of the clinical phenotype alongside epileptic seizures; however, the underlying neurophysiological mechanisms remain unclear. Auditory steady‐state responses (ASSRs) to repetitive 40‐ and 80‐Hz stimuli are widely used measures of gamma‐band oscillations (GBOs ...
Ryo Mitoma   +12 more
wiley   +1 more source

Neuroimaging of the ictal–interictal continuum: Where do we stand? A systematic review and meta‐analysis of current evidence

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Patterns within the ictal–interictal continuum (IIC) are frequently encountered in critically ill patients undergoing continuous electroencephalographic studies and may reflect ongoing ictal activity or secondary brain injury. Peri‐ictal neuroimaging abnormalities (PNA) have been described in association with status epilepticus (SE),
Panagiota‐Eleni Tsalouchidou   +10 more
wiley   +1 more source

Economic burden and cost determinants of epilepsy in Georgia: A longitudinal cost‐of‐illness study

open access: yesEpilepsia Open, EarlyView.
Abstract Objective To assess the economic burden, cost components, and individual‐level determinants of outpatient epilepsy care in adults in Georgia. Methods This longitudinal study of epilepsy‐related costs in adults with active epilepsy attending a tertiary epilepsy centre in Tbilisi collected clinical and sociodemographic data over 6 months. Direct
Sofia Kasradze   +5 more
wiley   +1 more source

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