S100B is increased in Parkinson’s disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway [PDF]
, 2012 Peer reviewedPublisher ...
Berg, Daniela +12 more
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Dementia with Lewy bodies [PDF]
Clinical Medicine, 2019 Editor – Akintade and Pierres provide a useful review of the evaluation of cognitive impairment in their Acute Medical Care (AMC) report in July’s Clinical Medicine .[1][1] However, the patient described in their report does not have dementia with Lewy bodies (DLB).
openaire +5 more sources
Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease. [PDF]
, 2015 BackgroundParkinson's disease (PD) is one of the most common causes of dementia and motor deficits in the elderly. PD is characterized by the abnormal accumulation of the synaptic protein alpha-synuclein (α-syn) and degeneration of dopaminergic neurons ...
Anderson, Scott +4 more
core +2 more sources
Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: Involvement of retrograde and anterograde axonal propagation. [PDF]
, 2020 In Parkinson's disease, some of the first alpha-synuclein aggregates appear in the olfactory system and the dorsal motor nucleus of the vagus nerve before spreading to connected brain regions.
Brundin, Patrik +3 more
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Is Cell Death Primary or Secondary in the Pathophysiology of Idiopathic Parkinson’s Disease?
Biomolecules, 2015 Currently, the pathophysiology of idiopathic Parkinson’s disease is explained by a loss of mainly dopaminergic nerve cells that causes a neurotransmitter deficiency.
Walter J. Schulz-Schaeffer
doaj +1 more source
Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in alzheimer’s disease and parkinson’s disease [PDF]
, 2017 Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases of the elderly people that have devastating effects in terms of morbidity and mortality.
Chakrabarti, S. +3 more
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, 2019 Parkinson's disease (PD) is characterized by the presence of α-synuclein aggregates known as Lewy bodies and Lewy neurites, whose formation is linked to disease development. The causal relation between α-synuclein aggregates and PD is not well understood.
Anichtchik, O. +12 more
core +1 more source
Neuroinflammation in Lewy body dementia. [PDF]
, 2015 Neuroinflammation is increasingly recognized as a key factor in the pathogenesis of neurodegenerative conditions. However, it remains unclear whether it has a protective or damaging role.
O'Brien, John T +2 more
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Probable Early-Onset Alzheimer's Disease in an Apolipoprotein E2 Homozygote [PDF]
, 2010 Objective: To describe a case of early-onset Alzheimer's disease (AD) in an apolipoprotein (Apo) epsilon 2/epsilon 2 homozygote. Background: Apo epsilon 2/epsilon 2 is the rarest of the ApoE genotypes, representing only 1.4% of the population.
Belden, Christine +7 more
core +2 more sources
Lewy and his inclusion bodies: Discovery and rejection
Dementia & NeuropsychologiaFritz Jacob Heinrich Lewy described the pathology of Paralysis agitans [Parkinson disease] and was the first to identify eosinophilic inclusion bodies in neurons of certain brain nuclei, later known as Lewy bodies, the pathological signature of the Lewy ...
Eliasz Engelhardt +1 more
doaj +1 more source