Results 101 to 110 of about 91,122 (346)

Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies [PDF]

, 2021
Leah J. Weston, Teresa L. Stackhouse, Kateri J. Spinelli, Sydney Weber Boutros, Elizabeth P. Rose, Valerie R. Osterberg, Kelvin C. Luk, Jacob Raber, Tamily A. Weissman, Vivek K. Unni   +9 more
openalex   +1 more source

Neuroinflammation and myelin status in Alzheimer’s disease, Parkinson’s disease, and normal aging brains: A small sample study [PDF]

, 2019
Microglia and astrocytes play important roles in mediating the immune processes and nutritional support in the central nervous system (CNS). Neuroinflammation has been indicated in the progression of neurodegenerative diseases Alzheimer’s disease (AD ...
Benzinger, Tammie L. S., Han, Fei, Morris, John C., Perlmutter, Joel S., Perrin, Richard J., Wang, Qing, Wang, Yong, Xu, Jinbin   +7 more
core   +2 more sources

Mitochondria and the Actin Cytoskeleton in Neurodegeneration

Cytoskeleton, EarlyView.
ABSTRACT Mitochondrial dysfunction and cytoskeletal disorganization are widely recognized hallmarks of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS).
Shivani Tuli, Preet Patel, Aneri Shethji, David Gau   +3 more
wiley   +1 more source

Characterizing Alzheimer’s Disease and Related Dementia in a Hypertension Population Within the State of Florida Using Electronic Health Record–Based Data

Clinical Pharmacology &Therapeutics, EarlyView.
Hypertension is a known modifiable risk factor for Alzheimer’s disease and related dementia (ADRD). However, it is unknown how variance in hypertension control, antihypertensive medications, and social determinants of health, such as social deprivation index (SDI), influence the risk of developing ADRD.
Eissa A. Jafari, Mona Alshahawey, Muhammad A. Zaman, Steven M. Smith, Yan Gong, Glenn E. Smith, Caitrin W. McDonough   +6 more
wiley   +1 more source

Early manifestation of depressive‐like behavior in transgenic mice that express dementia with Lewy body‐linked mutant β‐synuclein

Neuropsychopharmacology Reports, 2018
Aim We previously generated transgenic (Tg) mice that expressed P123H β‐synuclein (βS), a dementia with Lewy body‐linked mutant βS. Notably, these mice recapitulated neurodegenerative features of Lewy body disease, reflected by motor dysfunction, greater
Masayo Fujita, Yoko Hagino, Yukio Takamatsu, Yuka Shimizu, Yoshiki Takamatsu, Kazutaka Ikeda, Makoto Hashimoto   +6 more
doaj   +1 more source

Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo. [PDF]

, 2009
Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography ...
Jagust, WJ, Rabinovici, GD
core   +2 more sources

Advection‐Pressure Splitting Schemes Applied to a Non‐Conservative 1D Blood Flow Model With Transport for Arteries and Veins

International Journal for Numerical Methods in Fluids, EarlyView.
We introduce new efficient and accurate first order finite volume‐type numerical schemes, for the non‐conservative one‐dimensional blood flow equations with transport, taking into account different velocity profiles. The framework is the flux‐vector splitting approach of Toro and Vázquez‐Cendón (2012), that splits the system in two subsystems of PDEs ...
Alessandra Spilimbergo, Eleuterio F. Toro, Annunziato Siviglia, Lucas O. Müller   +3 more
wiley   +1 more source

Neural correlates of attention-executive dysfunction in lewy body dementia and Alzheimer's disease. [PDF]

, 2015
Attentional and executive dysfunction contribute to cognitive impairment in both Lewy body dementia and Alzheimer's disease. Using functional MRI, we examined the neural correlates of three components of attention (alerting, orienting, and executive ...
Alan J. Thomas, Alexopoulos, Alison Killen, Ashburner, Baddeley, Ballard, Bentley, Bentley, Benton, Binder, Binder, Binnewijzend, Blanc, Bokde, Bosboom, Broks, Bronnick, Browndyke, Buckner, Buckner, Calderon, Celone, Corbetta, Cummings, Dam, David J. Burn, Delli Pizzi, Dosenbach, Downar, Downar, Emre, Fan, Fan, Ferman, Ferman, Fernandez-Duque, Fernández, Festa-Martino, Franciotti, Fuentes, Galvoa-Carmona, George Cherry, Gratwicke, Greicius, Hafkemeijer, Helmich, John T. O'Brien, John-Paul Taylor, Kehagia, Kenny, Kertzman, Kikuchi, Kincade, Lee, Leech, Liu, Lustig, MacDonald, MacLeod, Madhyastha, Mak, McGuiness, McKeith, McKeith, McKhann, Meppelink, Metzler-Baddeley, Michael Firbank, Molloy, Mosimann, Noe, Peraza, Peter Gallagher, Petrou, Pihlajamaki, Posner, Raichle, Rinne, Risacher, Rombouts, Rombouts, Sauer, Shine, Shulman, Sidlauskaite, Singh, Sperling, Sperling, Tales, Tales, Taylor, Thiel, Tsuboi, Vann Jones, Walker, Wang, Weinbach, Weissman, Wylie, Xenia Kobeleva, Zheng, Zhong   +101 more
core   +1 more source

Efficacy of omega‐3 fatty acids as a functional food: a multifaceted approach to health reinforcement

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Omega‐3 fatty acids (omega‐3s) are polyunsaturated fatty acids linked with numerous health benefits. Omega‐3s exhibit multifaceted activities through various mechanisms. Eicosapentaenoic acid (EPA) alleviates oxidative stress by lowering reactive oxygen species and improving oxidative stress in brain tissues and acts against neurodegenerative ...
Md Faruque Ahmad, Abdulrahman A Alsayegh, Anjum Khanam, Awais Ahmed, António Raposo, Farkad Bantun, Md Zeyaullah, Ahmad O Babalghith, Abdullah F Aldairi, Boshra Mozaffar, Mohammed F Bajahzer, Mohamed H Abdelrahman, Mohammad Intakhab Alam   +12 more
wiley   +1 more source

Dementia with Lewy bodies: association of Alzheimer pathology with functional connectivity networks [PDF]

, 2021
Julia Schumacher, Jeffrey L. Gunter, Scott A. Przybelski, David T. Jones, Jonathan Graff‐Radford, Rodolfo Savica, Christopher G. Schwarz, Matthew L. Senjem, Clifford R. Jack, Val J. Lowe, David S. Knopman, Julie A. Fields, Walter K. Kremers, Ronald C. Petersen, Neill R. Graff‐Radford, Tanis J. Ferman, Bradley F. Boeve, Alan Thomas, John‐Paul Taylor, Kejal Kantarci   +19 more
openalex   +1 more source