Results 171 to 180 of about 91,122 (346)

Clinical and Imaging Characteristics of Parkinson's Disease with Negative Alpha‐Synuclein Seed Amplification Assay

Movement Disorders, EarlyView.
Abstract Background The cerebrospinal fluid alpha‐synuclein seed amplification assay (CSFasynSAA) detects alpha‐synuclein aggregation in over 90% of individuals with sporadic PD (sPD). However, the clinical characteristics of sPD with negative CSFasynSAA remain undefined.
Sarah M. Brooker, Jacopo Pasquini, Seung Ho Choi, David‐Erick Lafontant, Seyed‐Mohammad Fereshtehnejad, Yashar Zeighami, Piergiorgio Grillo, Giulietta M. Riboldi, Houman Azizi, Roqaie Moqadam, Un Jung Kang, Kelly N.H. Nudelman, Andrew Siderowf, Caroline M. Tanner, Thomas F. Tropea, Tatiana Foroud, Lana M. Chahine, Brit Mollenhauer, Kalpana M. Merchant, Douglas Galasko, Christopher S. Coffey, Roseanne D. Dobkin, Ethan G. Brown, Roy N. Alcalay, Daniel Weintraub, Kenneth Marek, Tanya Simuni, Paulina Gonzalez‐Latapi, Nicola Pavese, Kathleen L. Poston, the Parkinson's Progression Markers Initiative   +30 more
wiley   +1 more source

Sex differences in dementia with Lewy bodies: an imaging study of neurotransmission pathways [PDF]

, 2023
Cecilia Boccalini, Nicolas Nicastro, Débora Elisa Peretti, Silvia Paola Caminiti, Daniela Perani, Valentina Garibotto   +5 more
openalex   +1 more source

Early Autonomic Burden in Prodromal Parkinson's Disease Predicts Cognitive Impairment

Movement Disorders, EarlyView.
Abstract Background Autonomic dysfunction is a known contributor to cognitive impairment in Parkinson's disease (PD), but its impact during prodromal stage is unknown. Objective The aim was to determine whether early autonomic burden predicts incident cognitive impairment in prodromal PD.
A. Enrique Martinez‐Nunez, Kelly A. Mills, Joseph Seemiller, Christopher B. Morrow, Gregory M. Pontone, Abhimanyu Mahajan   +5 more
wiley   +1 more source

Kinetic Compensation of Barrel Launch Under High‐Speed Solid‐Phase Particulate Impacts

International Journal of Mechanical System Dynamics, EarlyView.
ABSTRACT An accurate launch‐dynamics computational method is critical for barrel weapon service life assessment and multiphase physics field refinement. Given the lack of studies on the solid‐phase buildup behavior at the projectile base, this paper provides an improved method for calculating the launching dynamics under high pressure and high speed ...
Zhiyi He, Guolai Yang, Quanzhao Sun, Shuli Li   +3 more
wiley   +1 more source

Lewy bodies [PDF]

American Journal of Psychiatry, 1997
openaire   +2 more sources

Regional analysis and genetic association of nigrostriatal degeneration in Lewy body disease

, 2017
Koji Kasanuki, Michael G. Heckman, Nancy N. Diehl, Melissa E. Murray, Shunsuke Koga, Alexandra I. Soto, Owen A. Ross, Dennis W. Dickson   +7 more
openalex   +2 more sources

Pleiotropic effects of variants in dementia genes in Parkinson disease [PDF]

, 2018
Benitez, Bruno A, Budde, John, Cooper, Breanna, Cruchaga, Carlos, David, Albert A, Diez-Fairen, Monica, Dube, Umber, Fernandez, Maria V, Ibanez, Laura, Ortega-Cubero, Sara, Pastor, Pau, Perlmutter, Joel S   +11 more
core   +2 more sources

Numerical Insights Into the Resistance Reduction Mechanisms of Forward Tapered Transoms in High‐Speed Catamaran: A Computational Fluid Dynamics‐Based Study

International Journal of Mechanical System Dynamics, EarlyView.
ABSTRACT This study investigates the hydrodynamic influence of forward transom tapering on a displacement catamaran hull using computational fluid dynamics (CFD) simulations. Five taper configurations ranging from a vertical transom base design to a fully tapered stern (1.00B) were evaluated over a wide Froude number range (Fr = .3 to 1.0).
Chalermkiat Nuchturee, Chairat Napasaksri, Ramil Kesvarakul, Sarawuth Srinakaew   +3 more
wiley   +1 more source

Probing Early α‐Synuclein Oligomers: Insights Into Aggregation Pathways of NACore and preNAC Segments Probed by Trapped Ion‐Mobility Mass Spectrometry and Fluorescence Spectroscopy

PROTEOMICS, EarlyView.
ABSTRACT Misfolding and aggregation of α‐Synuclein (α‐Syn) play a central role in Parkinson's disease (PD), with oligomeric intermediates implicated as key toxic species. Here, we investigate the aggregation of two α‐Syn segments, the NACore (68GAVVTGVTAVA78, WT‐PD1) and the preNAC region (47GVVHGVATVA56, WT‐PD2), using high‐resolution trapped ion ...
Agathe Depraz Depland, Stephanie Mikromanolis, Iuliia Stroganova, Anouk M. Rijs   +3 more
wiley   +1 more source

α-Synuclein ubiquitination – functions in proteostasis and development of Lewy bodies [PDF]

Hung-Hsiang Ho, Simon S. Wing
openalex   +1 more source