Results 11 to 20 of about 72,581 (277)
Neuropathological evidence of body-first vs. brain-first Lewy body disease
Neurobiology of Disease, 2021 Aggregation of alpha-synuclein into inclusion bodies, termed Lewy pathology, is a defining feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB).
Per Borghammer +7 more
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Molecular Pathology of Lewy Body Diseases [PDF]
International Journal of Molecular Sciences, 2009 Lewy body diseases are characterized by the presence of Lewy bodies, alpha-synuclein(AS)-positive inclusions in the brain. Since their main component is conformationally modified AS, aggregation of the latter is thought to be a key pathogenic event in these diseases.
Beyer, Katrin +2 more
openaire +5 more sources
Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium
Frontiers in Neurology, 2022 The Lewy Body Dementia Association (LBDA) held a virtual event, the LBDA Biofluid/Tissue Biomarker Symposium, on January 25, 2021, to present advances in biomarkers for Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLBs) and ...
Gregory D. Scott +54 more
doaj +1 more source
Sex differences in clinical cognitive impairment with Lewy bodies: a Chinese multicenter study
Biology of Sex Differences, 2022 Highlights There are significant sex differences in Chinese population with cognitive impairment in Lewy body disease. Women were more common in dementia with Lewy bodies and mild cognitive impairment with Lewy bodies cases, had more frequent and severe ...
Jinghuan Gan +15 more
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Alterations in peptide levels in Parkinson's disease and incidental Lewy body disease [PDF]
, 2007 The levels of the neuropeptides Met- and Leu-enkephalin (MET-ENK, LEU-ENK), substance P and neurotensin were measured by a combined high performance liquid chromatography/radioimmunoassay (HPLC/RIA) method in postmortem samples of basal ganglia from ...
Beyer, Cordian +6 more
core +1 more source
Neuroinflammation in Lewy body dementia. [PDF]
, 2015 Neuroinflammation is increasingly recognized as a key factor in the pathogenesis of neurodegenerative conditions. However, it remains unclear whether it has a protective or damaging role.
O'Brien, John T +2 more
core +2 more sources
Neural correlates of attention-executive dysfunction in lewy body dementia and Alzheimer's disease. [PDF]
, 2015 Attentional and executive dysfunction contribute to cognitive impairment in both Lewy body dementia and Alzheimer's disease. Using functional MRI, we examined the neural correlates of three components of attention (alerting, orienting, and executive ...
Alan J. Thomas +101 more
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The Alzheimer variant of Lewy body disease: A pathologically confirmed case-control study [PDF]
, 2005 The objective of the study was to identify clinical features that distinguish patients with dementia with Lewy bodies (DLB), who were classified as Alzheimer's disease ( AD) patients, from patients with AD.
Busch, R. +7 more
core +1 more source
Cortical Lewy body disease [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 2004 Cortical Lewy body disease reflects the presence of cortical Lewy bodies but without a clear clinical correlation Cortical Lewy body disease is a pathological observation rather than a distinct clinicopathological entity. Cortical Lewy bodies (CLB) are typically found in Parkinson’s disease and dementia with Lewy bodies (DLB), although they may also ...
openaire +2 more sources
Alzheimer’s Research & Therapy, 2022 Drug repositioning and repurposing has proved useful in identifying new treatments for many diseases, which can then rapidly be brought into clinical practice.
John T. O’Brien +5 more
doaj +1 more source