Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy. [PDF]
PLoS ONE, 2013 Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr-mediated linezolid
Josep M Sierra +6 more
doaj +2 more sources
Resistance to Linezolid Caused by Modifications at Its Binding Site on the Ribosome [PDF]
Antimicrobial Agents and Chemotherapy, 2012 Linezolid is an oxazolidinone antibiotic in clinical use for the treatment of serious infections of resistant Gram-positive bacteria. It inhibits protein synthesis by binding to the peptidyl transferase center on the ribosome. Almost all known resistance
Birte Vester
exaly +3 more sources
Population Pharmacokinetic Model‐Based Optimization of Linezolid Dosing in Hematooncological Patients With Suspected or Proven Gram‐Positive Sepsis [PDF]
Clinical and Translational ScienceThe objective of this study was to develop a population pharmacokinetic model for linezolid in hematooncological patients with sepsis, and to propose dosing optimization based on pharmacokinetic covariates that would lead to improved achievement of the ...
Alžběta Zavřelová +9 more
doaj +2 more sources
Protective Effect of Exogenous Adenosine Triphosphate Against Ocular Toxicity of Linezolid in Rats [PDF]
LifeLinezolid, a synthetic antimicrobial agent, may induce oxidative damage in ocular tissues, particularly in the optic nerve. Adenosine triphosphate (ATP) is involved in the production of antioxidants that scavenge and neutralize reactive oxygen species ...
Cenap Mahmut Esenulku +8 more
doaj +2 more sources
Effects of a rifampicin pre-treatment on linezolid pharmacokinetics.
PLoS ONE, 2019 Linezolid is an oxazolidinone antibiotic that effectively treats methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).
Fumiyasu Okazaki +5 more
doaj +3 more sources
EBioMedicine, 2015 Long-term linezolid use is limited by mitochondrial toxicity-associated adverse events (AEs). Within a prospective, randomized controlled trial of linezolid to treat chronic extensively drug-resistant tuberculosis, we serially monitored the translational
Yumi Park, Laura E Via, Sang Nae Cho
exaly +3 more sources
Frontiers in Pharmacology, 2023 Linezolid combined with rifampicin has shown excellent clinical outcomes against infection by multi-resistant Gram-positive bacteria. However, several studies have indicated that rifampicin reduces the plasma concentration of linezolid in patients with ...
Pan Yan +4 more
doaj +1 more source
Parallel evolution of linezolid-resistant Staphylococcus aureus in patients with cystic fibrosis
Microbiology Spectrum, 2023 Linezolid is an antibiotic used to treat serious Staphylococcus aureus infections. Resistance to linezolid is considered rare but could emerge with repeated dosing.
Nicholas J. Pitcher +13 more
doaj +1 more source
Journal of Global Antimicrobial Resistance, 2022 : Objectives: Linezolid-dependent growth has contributed to wide dissemination of Staphylococcus epidermidis in hospitals. This study aimed to characterise linezolid-resistant coagulase-negative staphylococci (CoNS) isolates and the possibility of ...
Fei Jiang +6 more
doaj +1 more source
Linezolid for the Treatment of Urinary Tract Infections Caused by Vancomycin-Resistant Enterococci
Pharmacy, 2021 Vancomycin-resistant enterococci (VRE) account for a large proportion of hospital-acquired infections. Determining optimal treatment of VRE urinary tract infections (UTIs) is challenging.
Mary Joyce Wingler +5 more
doaj +1 more source