Results 1 to 10 of about 38,540 (200)
Linezolid for the Treatment of Urinary Tract Infections Caused by Vancomycin-Resistant Enterococci [PDF]
Vancomycin-resistant enterococci (VRE) account for a large proportion of hospital-acquired infections. Determining optimal treatment of VRE urinary tract infections (UTIs) is challenging.
Mary Joyce Wingler +5 more
doaj +2 more sources
Protective effects of adenosine triphosphate, thiamin, thiamin pyrophosphate, and their combination against linezolid-induced renal injury and lactic acidosis in rats [PDF]
Linezolid, an oxazolidinone antibiotic effective against Gram-positive pathogens, may cause nephrotoxicity and lactic acidosis during prolonged therapy. This experimental study investigated the protective effects of adenosine triphosphate (ATP), thiamin,
Ozlem Admis +7 more
doaj +2 more sources
Effects of a rifampicin pre-treatment on linezolid pharmacokinetics.
Linezolid is an oxazolidinone antibiotic that effectively treats methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).
Fumiyasu Okazaki +5 more
doaj +3 more sources
Long-term linezolid use is limited by mitochondrial toxicity-associated adverse events (AEs). Within a prospective, randomized controlled trial of linezolid to treat chronic extensively drug-resistant tuberculosis, we serially monitored the translational
Yumi Park, Laura E Via, Sang Nae Cho
exaly +3 more sources
Protective Effect of Exogenous Adenosine Triphosphate Against Ocular Toxicity of Linezolid in Rats [PDF]
Linezolid, a synthetic antimicrobial agent, may induce oxidative damage in ocular tissues, particularly in the optic nerve. Adenosine triphosphate (ATP) is involved in the production of antioxidants that scavenge and neutralize reactive oxygen species ...
Cenap Mahmut Esenulku +8 more
doaj +2 more sources
Linezolid combined with rifampicin has shown excellent clinical outcomes against infection by multi-resistant Gram-positive bacteria. However, several studies have indicated that rifampicin reduces the plasma concentration of linezolid in patients with ...
Pan Yan +4 more
doaj +1 more source
Parallel evolution of linezolid-resistant Staphylococcus aureus in patients with cystic fibrosis
Linezolid is an antibiotic used to treat serious Staphylococcus aureus infections. Resistance to linezolid is considered rare but could emerge with repeated dosing.
Nicholas J. Pitcher +13 more
doaj +1 more source
: Objectives: Linezolid-dependent growth has contributed to wide dissemination of Staphylococcus epidermidis in hospitals. This study aimed to characterise linezolid-resistant coagulase-negative staphylococci (CoNS) isolates and the possibility of ...
Fei Jiang +6 more
doaj +1 more source
Linezolid is an oxazolidinone antibiotic. Linezolid-associated lactic acidosis has been reported in 6.8% of linezolid-treated patients. Lactic acidosis is associated with poor clinical outcomes, with high blood lactate levels resulting in organ ...
Naiju Zhang +5 more
doaj +1 more source
Different intra-cerebrospinal distribution of linezolid in patients with inflammatory meningitis
Linezolid has excellent antibiotic activity against gram-positive organisms and is expected to be an alternative to vancomycin for the treatment of bacterial meningitis.
Naoki Ichinose +9 more
doaj +1 more source

