Results 1 to 10 of about 38,540 (200)

Linezolid for the Treatment of Urinary Tract Infections Caused by Vancomycin-Resistant Enterococci [PDF]

open access: goldPharmacy, 2021
Vancomycin-resistant enterococci (VRE) account for a large proportion of hospital-acquired infections. Determining optimal treatment of VRE urinary tract infections (UTIs) is challenging.
Mary Joyce Wingler   +5 more
doaj   +2 more sources

Protective effects of adenosine triphosphate, thiamin, thiamin pyrophosphate, and their combination against linezolid-induced renal injury and lactic acidosis in rats [PDF]

open access: yesRenal Failure
Linezolid, an oxazolidinone antibiotic effective against Gram-positive pathogens, may cause nephrotoxicity and lactic acidosis during prolonged therapy. This experimental study investigated the protective effects of adenosine triphosphate (ATP), thiamin,
Ozlem Admis   +7 more
doaj   +2 more sources

Effects of a rifampicin pre-treatment on linezolid pharmacokinetics.

open access: goldPLoS ONE, 2019
Linezolid is an oxazolidinone antibiotic that effectively treats methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).
Fumiyasu Okazaki   +5 more
doaj   +3 more sources

Linezolid Trough Concentrations Correlate with Mitochondrial Toxicity-Related Adverse Events in the Treatment of Chronic Extensively Drug-Resistant Tuberculosis

open access: yesEBioMedicine, 2015
Long-term linezolid use is limited by mitochondrial toxicity-associated adverse events (AEs). Within a prospective, randomized controlled trial of linezolid to treat chronic extensively drug-resistant tuberculosis, we serially monitored the translational
Yumi Park, Laura E Via, Sang Nae Cho
exaly   +3 more sources

Protective Effect of Exogenous Adenosine Triphosphate Against Ocular Toxicity of Linezolid in Rats [PDF]

open access: yesLife
Linezolid, a synthetic antimicrobial agent, may induce oxidative damage in ocular tissues, particularly in the optic nerve. Adenosine triphosphate (ATP) is involved in the production of antioxidants that scavenge and neutralize reactive oxygen species ...
Cenap Mahmut Esenulku   +8 more
doaj   +2 more sources

Evaluation of the impact of rifampicin on the plasma concentration of linezolid in tuberculosis co-infected patients

open access: yesFrontiers in Pharmacology, 2023
Linezolid combined with rifampicin has shown excellent clinical outcomes against infection by multi-resistant Gram-positive bacteria. However, several studies have indicated that rifampicin reduces the plasma concentration of linezolid in patients with ...
Pan Yan   +4 more
doaj   +1 more source

Parallel evolution of linezolid-resistant Staphylococcus aureus in patients with cystic fibrosis

open access: yesMicrobiology Spectrum, 2023
Linezolid is an antibiotic used to treat serious Staphylococcus aureus infections. Resistance to linezolid is considered rare but could emerge with repeated dosing.
Nicholas J. Pitcher   +13 more
doaj   +1 more source

Phenotypic and genotypic characterisation of linezolid-resistant coagulase-negative staphylococci possessing cfr-carrying plasmid

open access: yesJournal of Global Antimicrobial Resistance, 2022
: Objectives: Linezolid-dependent growth has contributed to wide dissemination of Staphylococcus epidermidis in hospitals. This study aimed to characterise linezolid-resistant coagulase-negative staphylococci (CoNS) isolates and the possibility of ...
Fei Jiang   +6 more
doaj   +1 more source

Successful treatment of linezolid-induced severe lactic acidosis with continuous venovenous hemodiafiltration: A case report

open access: yesSaudi Pharmaceutical Journal, 2022
Linezolid is an oxazolidinone antibiotic. Linezolid-associated lactic acidosis has been reported in 6.8% of linezolid-treated patients. Lactic acidosis is associated with poor clinical outcomes, with high blood lactate levels resulting in organ ...
Naiju Zhang   +5 more
doaj   +1 more source

Different intra-cerebrospinal distribution of linezolid in patients with inflammatory meningitis

open access: yesInternational Journal of Infectious Diseases, 2021
Linezolid has excellent antibiotic activity against gram-positive organisms and is expected to be an alternative to vancomycin for the treatment of bacterial meningitis.
Naoki Ichinose   +9 more
doaj   +1 more source

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