Results 31 to 40 of about 890,691 (262)
Current Issues in Molecular Biology, 2023 Atherosclerosis is driven by intimal arterial macrophages accumulating cholesterol. Atherosclerosis also predominantly occurs in areas consisting of proinflammatory arterial endothelial cells.
Jing Echesabal-Chen +8 more
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Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation
Nature Communications, 2023 Accumulation of lipid-laden macrophages within the arterial neointima is a critical step in atherosclerotic plaque formation. Here, we show that reduced levels of the cellular plasticity factor ZEB1 in macrophages increase atherosclerotic plaque ...
M. C. Martinez-Campanario +16 more
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The fat is in the lysosome: how Mycobacterium tuberculosis tricks macrophages into storing lipids
The Journal of Clinical Investigation, 2023 Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects primarily macrophages, causing them to differentiate into lipid-laden foamy macrophages that are a primary source of tissue destruction in patients with TB.
Yoann Rombouts, Olivier Neyrolles
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Xanthomatosis: An Insight to Familial Hypercholesterolemia [PDF]
National Journal of Laboratory Medicine, 2016 Familial hypercholesterolemia is a “RECEPTOR DISEASE” that is the consequence of a mutation in the gene encoding the receptor for low-density lipoprotein, which is involved in the transport and metabolism of cholesterol.
Jaya Manchanda +3 more
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Shine like gold and sparkle like glitter: Three cases of lipoid pneumonia
Respiratory Medicine Case Reports, 2021 Lipoid pneumonia (LP) is an unwonted, mostly asymptomatic entity which has no classical radiological appearance. It can be endogenous or exogenous depending upon the type of exposure or underlying milieu.
Vishak Acharya +4 more
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Cellular Physiology and Biochemistry, 2014 Aims: γ-aminobutyric acid (GABA), the principal inhibitory neurotransmitter, acts on GABA receptors to play an important role in the modulation of macrophage functions.
Ying Yang +5 more
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Lipid-Laden Macrophages Downregulate AKT Phosphorylation and Metabolize Lipid Droplets via Autophagy [PDF]
, 2017 Macrophages contribute to plaque formation in atherosclerosis. Macrophages take up modified low-density lipoproteins and store excess cholesterol and triglycerides in lipid droplet organelles.
Sultana, Rifat
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Journal of Mid-Life Health, 2023 Xanthogranulomatous inflammation, a specific form of chronic inflammation, is marked by parenchymal destruction, proliferative fibrosis, and infiltration of typical foamy histiocytes admixed with hemosiderin-laden macrophages and foreign-body giant cells.
Mukta Pujani +5 more
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A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages
The Journal of Clinical Investigation, 2023 Induction of lipid-laden foamy macrophages is a cellular hallmark of tuberculosis (TB) disease, which involves the transformation of infected phagolysosomes from a site of killing into a nutrient-rich replicative niche.
Melissa Bedard +22 more
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Colony Stimulating Factor-1 Receptor (CSF-1R) Expression, Degradation, and Signaling in Lipid-Laden Macrophages [PDF]
, 2016 Atherosclerosis is a serious disease affecting a large portion of the world’s population. In atherosclerosis, macrophages become filled with lipid droplets and form fatty plaques in artery walls.
Thompson, Gregory
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