Results 41 to 50 of about 890,691 (262)

Lipid-laden macrophage index and inflammation in bronchoalveolar lavage fluids in children [PDF]

European Respiratory Journal, 2001
The presence of lipids in alveolar macrophages has been used clinically as an indicator of aspiration, a process associated with increased lung inflammation in animal models. The hypothesis is that the quantity of lipids in alveolar macrophages, measured as lipid-laden index (LLI), would correlate with lung inflammation in paediatric patients.Children ...
M Y, Kazachkov, M S, Muhlebach, C A, Livasy, T L, Noah   +3 more
openaire   +2 more sources

Aged lipid‐laden microglia display impaired responses to stroke [PDF]

, 2022
Microglial cells of the aged brain manifest signs of dysfunction that could contribute to the worse neurological outcome of stroke in the elderly. Treatment with colony‐stimulating factor 1 receptor antagonists enables transient microglia depletion that ...
Casal, Carme, Pol, Albert, Lozano Salvatella, Juan José, Anna M Planas, Jordi Pedragosa, Mattia Gallizioli, Juan J Lozano, Arbaizar Rovirosa, Maria, Pedragosa Ollé, Jordi, Casal, Carmen, Pol i Sorolla, Albert, Planas Obradors, Anna Maria, Gallizioli, Mattia, Arbaizar-Rovirosa, María, Maria Arbaizar‐Rovirosa, Carme Casal, Albert Pol, Pedragosa, Jordi, Lozano, Juan J., Planas, Anna M.   +19 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Lipid-laden alveolar macrophages in induced sputum in patients with gastroesophageal reflux disease

Бюллетень сибирской медицины, 2006
The aim of the study was to evaluate the diagnostic role of a lipid index of macrophages in induced sputum as a marker of aspiration of acidic gastric contents.
L. I. Volkova, O. A. Anichkina, I. V. Sukhodolo, R. I. Pleshko, V. S. Bogomyagkov   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice[S]

Journal of Lipid Research, 2019
Angiopoietin-like protein (ANGPTL)4 regulates plasma lipids, making it an attractive target for correcting dyslipidemia. However, ANGPTL4 inactivation in mice fed a high fat diet causes chylous ascites, an acute-phase response, and mesenteric ...
Antwi-Boasiako Oteng, PhilipM.M. Ruppert, Lily Boutens, Wieneke Dijk, XantheA.M.H. van Dierendonck, Gunilla Olivecrona, Rinke Stienstra, Sander Kersten   +7 more
doaj   +1 more source

Xanthogranulomatous salpingo-oophoritis associated with diverticular perforation

Human Pathology: Case Reports, 2021
Xanthogranulomatous inflammation of the female genital tract is a rare entity with less than thirty cases being previously reported in the literature. It is characterized by destruction of the normal tissue followed by replacement with inflammatory cells
Bistees George, Cecilia G. Clement
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source