Lipid-laden bronchoalveolar macrophages in asthma and chronic cough [PDF]
Respiratory Medicine, 2014 The presence of lipids in alveolar macrophages (AMs) may impair their phagocytic response, and determine airway inflammation and obstruction.To determine the factors such as severity of asthma, chronic cough, airway inflammation and obesity that may influence the presence of lipids in lung macrophages.Bronchoalveolar lavage fluid (BALF) was obtained ...
Kian Fan Chung, W Banya, K F Chung
exaly +5 more sources
PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site
Neurobiology of Disease, 2023 After spinal cord injury (SCI), infiltrating macrophages undergo excessive phagocytosis of myelin and cellular debris, forming lipid-laden foamy macrophages. To understand their role in the cellular pathology of SCI, investigation of the foamy macrophage
Christine B. Ryan +7 more
doaj +4 more sources
Lipid-Laden Alveolar Macrophages and pH Monitoring in Gastroesophageal Reflux-Related Respiratory Symptoms [PDF]
Pulmonary Medicine, 2012 Lipid-laden alveolar macrophages and pH monitoring have been used in the diagnosis of chronic aspiration in children with gastroesophageal reflux (GER).
R. Kitz +3 more
doaj +2 more sources
Lipid-Laden Macrophages Recycle Myelin to Feed Glioblastoma. [PDF]
Cancer ResTumor-associated microglia and macrophages (TAM) make up the largest immune cell population in the glioblastoma (GBM) tumor microenvironment. Given the heterogeneity and plasticity of TAMs in the GBM tumor microenvironment, understanding the context-dependent cancer cell–TAM symbiotic interaction is crucial for
Pang L, Zhou F, Chen P.
europepmc +3 more sources
HILPDA Uncouples Lipid Droplet Accumulation in Adipose Tissue Macrophages from Inflammation and Metabolic Dysregulation [PDF]
Cell Reports, 2020 Summary: Obesity leads to a state of chronic, low-grade inflammation that features the accumulation of lipid-laden macrophages in adipose tissue. Here, we determined the role of macrophage lipid-droplet accumulation in the development of obesity-induced ...
Xanthe A.M.H. van Dierendonck +9 more
doaj +2 more sources
Pulmonary Lipid-Laden Macrophages and Vaping
New England Journal of Medicine, 2019 Pulmonary Lipid-Laden Macrophages and Vaping The use of electronic cigarettes has been associated with pulmonary injury, one feature of which has been lipid-laden macrophages in pulmonary-lavage fl...
Sean D Maddock +2 more
exaly +3 more sources
Myelin debris uptake by macrophages and microglia: Resolution of foam cells with a series of novel cyclodextrins [PDF]
NeurotherapeuticsFoamy, lipid-laden macrophages are found in multiple sclerosis (MS) lesions, resulting from excessive phagocytosis of myelin debris following demyelination.
Emily C. Wuerch +7 more
doaj +2 more sources
Lipid-Laden alveolar macrophages and vaping: Lessons from EVALI [PDF]
EBioMedicine, 2020 Andrea Jonas
doaj +3 more sources
Lipid-laden macrophages in atherosclerosis and cancer
Seminars in Cancer BiologyThis review explores the dual roles of lipid-laden macrophages (LL-Macs) in inflammation, atherosclerosis and cancer, emphasizing both their shared and divergent functions across physiological and pathological conditions. Lipid metabolism regulates the polarization of macrophages in homeostasis and inflammation.
Vicente Andrés +2 more
exaly +3 more sources
Lipid-Laden M1-like Macrophages of Familial Hypercholesterolemia Patients Are Characterized by Increased Interleukin-1β Secretion and Reduced TMEM176A and TMEM176B Gene Expression [PDF]
Current Issues in Molecular BiologyFamilial hypercholesterolemia (FH) is a common hereditary dyslipidemia characterized by high levels of low-density lipoprotein (LDL) cholesterol and a risk of premature atherosclerosis. Previous studies showed that cardiovascular risks persist in FH even
Artem Izyumchenko +12 more
doaj +2 more sources