Results 81 to 90 of about 890,691 (262)

The ethanolamide metabolite of DHA, docosahexaenoylethanolamine, shows immunomodulating effects in mouse peritoneal and RAW264.7 macrophages: evidence for a new link between fish oil and inflammation [PDF]

, 2011
Several mechanisms have been proposed for the positive health effects associated with dietary consumption of long-chain n-3 PUFA (n-3 LC-PUFA) including DHA (22 : 6n-3) and EPA (20 : 5n-3).
Vincken, J.P., Balvers, M.G.J., Balvers, M., Poland, M., Gabriele, B., Meijerink, J., Witkamp, R.F., Plastina, P., Poland, M.C.R., Attya, M., Gruppen, H.   +10 more
core   +2 more sources

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Protocol for studying macrophage lipid crosstalk with murine tumor cells

STAR Protocols
Summary: Lipid accumulation has recently emerged as a key feature underlying the pro-tumorigenic role of macrophages. Here, we present a workflow to study macrophage lipid crosstalk with tumor cells. We describe steps for the identification, purification,
Daan J. Kloosterman, Martina Farber, Menno Boon, Johanna Erbani, Leila Akkari   +4 more
doaj   +1 more source

Treatment Of Gastroesophageal Reflux In Children With Lipid-Laden Macrophage

IRUPEC 2019 Kongresi Tam Metin Bildirileri, 2020
In chronic cough, one of the etiologies is microaspirations due to gastroesophageal reflux diseases. “Lipid-laden macrophage” (LLM) the definition of lipid-containing macrophage after staining with Sudan 4 or Oil Red O. It is considered as a sign of gastroesophageal reflux in recurrent pneumonia.
EĞİL, Oğuz, AKÇAY, Memduha, OLTULU, Pembe, PEKCAN, Sevgi   +3 more
openaire   +1 more source

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

Salicylate improves macrophage cholesterol homeostasis via activation of Ampk

Journal of Lipid Research, 2015
Atherosclerosis stems from imbalances in lipid metabolism and leads to maladaptive inflammatory responses. The AMP-activated protein kinase (Ampk) is a highly conserved serine/threonine kinase that regulates many aspects of lipid and energy metabolism ...
Morgan D. Fullerton, Rebecca J. Ford, Chelsea P. McGregor, Nicholas D. LeBlond, Shayne A. Snider, Stephanie A. Stypa, Emily A. Day, Šárka Lhoták, Jonathan D. Schertzer, Richard C. Austin, Bruce E. Kemp, Gregory R. Steinberg   +11 more
doaj   +1 more source

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

ATP-Responsive Multifunctional Supramolecular Polymer as a Nonviral Vector for Boosting Cholesterol Removal from Lipid-Laden Macrophages

, 2021
Specific delivery of NCEH1 plasmid is a promising approach to boost the cholesterol removal from lipid-laden macrophages for antiatherosclerosis. Polyethylenimine (PEI) is one of the most efficient gene carriers among nonviral vectors.
Li Liu (75607), Qiang Liu (166143), Cuiping Jiang (800494), Yao Chen (149006), Peiyi Liang (11566011), Lu Zhang (50563), Yankui Yi (11566017), Ziming Zhuang (11566014), Yuan Wang (14955)   +8 more
core   +1 more source

Increased atherosclerosis and expression of inflammarafts in macrophage foam cells in AIBP-deficient mice.

Scientific Reports
Atherosclerotic lesions comprise different populations of macrophages, including lipid-laden macrophage foam cells and non-foamy, inflammatory macrophages, which play distinct roles in disease progression.
Shenglin Li, Nicolaus Nazarenkov, Elena Alekseeva, Soo-Ho Choi, Juliana Maria Navia-Pelaez, Aakash Patel, Patrick Secrest, Philip L.S.M. Gordts, Sven Heinz, Yury I. Miller   +9 more
doaj   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source