Results 61 to 70 of about 3,287,800 (353)

Chemical chaperone 4-phenyl butyric acid (4-PBA) reduces hepatocellular lipid accumulation and lipotoxicity through induction of autophagy[S]

Journal of Lipid Research, 2017
Defective autophagy has been linked to lipotoxicity in several cellular models. We aimed to investigate autophagy in lipid-stimulated hepatoma (Huh7) cells and tested whether 4-phenyl butyric acid (4-PBA), a chemical chaperone, has a beneficial role in ...
Ashraf U. Nissar, Love Sharma, Malik A. Mudasir, Lone A. Nazir, Sheikh A. Umar, Parduman R. Sharma, Ram A. Vishwakarma, Sheikh A. Tasduq   +7 more
doaj   +1 more source

Senescent glia link mitochondrial dysfunction and lipid accumulation

Nature
Senescence is a cellular state linked to ageing and age-onset disease across many mammalian species1,2. Acutely, senescent cells promote wound healing3,4 and prevent tumour formation5; but they are also pro-inflammatory, thus chronically exacerbate ...
China N. Byrns, Alexandra E. Perlegos, Karl N. Miller, Zhecheng Jin, F. Carranza, Palak Manchandra, Connor H. Beveridge, Caitlin E. Randolph, V. S. Chaluvadi, Shirley L. Zhang, Ananth R. Srinivasan, F. C. Bennett, A. Sehgal, P. Adams, Gaurav Chopra, Nancy M. Bonini   +15 more
semanticscholar   +1 more source

Lipid Accumulation in Hearts Transplanted From Nondiabetic Donors to Diabetic Recipients.

Journal of the American College of Cardiology, 2020
BACKGROUND Early pathogenesis of diabetic cardiomyopathy (DMCM) may involve lipotoxicity of cardiomyocytes in the context of hyperglycemia. There are many preclinical studies of DMCM pathogenesis, but the human evidence is still poorly understood ...
R. Marfella, Cristiano Amarelli, F. Cacciatore, M. Balestrieri, G. Mansueto, N. D’Onofrio, S. Esposito, I. Mattucci, G. Salerno, M. de Feo, M. D'Amico, P. Golino, C. Maiello, G. Paolisso, C. Napoli   +14 more
semanticscholar   +1 more source

Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation

Nature Communications
Fully targeted mRNA therapeutics necessitate simultaneous organ-specific accumulation and effective translation. Despite some progress, delivery systems are still unable to fully achieve this.
Kexin Su, Lu Shi, Tao Sheng, Xinxin Yan, Lixin Lin, Chaoyang Meng, Shiqi Wu, Yuxuan Chen, Yao Zhang, Chaorong Wang, Zichuan Wang, Junjie Qiu, Jiahui Zhao, Tengfei Xu, Yuan Ping, Zhen Gu, Shuai Liu   +16 more
semanticscholar   +1 more source

Metformin reduces saturated fatty acid-induced lipid accumulation and inflammatory response by restoration of autophagic flux in endothelial cells

Scientific Reports, 2020
Autophagy, an integral part of the waste recycling process, plays an important role in cellular physiology and pathophysiology. Impaired autophagic flux causes ectopic lipid deposition, which is defined as the accumulation of lipids in non-adipose tissue.
Hae-Suk Kim, Guang Ren, Teayoun Kim, Sushant Bhatnagar, Qinglin Yang, Y. Bahk, Jeong-a Kim   +6 more
semanticscholar   +1 more source

Determinants of intramyocellular lipid accumulation in early childhood [PDF]

International Journal of Obesity, 2019
Accumulation of lipid droplets inside skeletal muscle fibers (intramyocellular lipids or IMCL) with increasing obesity has been linked to skeletal muscle insulin resistance and risk of type 2 diabetes in both adults and prepubertal children. We aimed to evaluate the associations of race, genotype, prenatal factors, and postnatal factors with IMCL in ...
Navin Michael, Varsha Gupta, Suresh Anand Sadananthan, Aparna Sampathkumar, Li Chen, Hong Pan, Mya Thway Tint, Kuan Jin Lee, See Ling Loy, Izzuddin M. Aris, Lynette Pei-Chi Shek, Fabian Kok Peng Yap, Keith M. Godfrey, Melvin K.-S. Leow, Yung Seng Lee, Michael S. Kramer, Christiani Jeyakumar Henry, Marielle Valerie Fortier, Yap Seng Chong, Peter D. Gluckman, Neerja Karnani, S. Sendhil Velan   +21 more
openaire   +4 more sources

Prenatal hyperandrogenism induces alterations that affect liver lipid metabolism [PDF]

, 2016
Prenatal hyperandrogenism is hypothesized as one of the main factors contributing to26 the development of polycystic ovary syndrome (PCOS). PCOS patients have high risk27 of developing fatty liver and steatosis.
Abruzzese, Giselle Adriana, Ferreira, Silvana Rocío, Heber, María Florencia, Motta, Alicia Beatriz, Pignataro, Omar Pedro, Reynoso, Roxana María, Velez, Leandro Martin   +6 more
core   +2 more sources

Pea Albumin Alleviates Oleic Acid-Induced Lipid Accumulation in LO2 Cells Through Modulating Lipid Metabolism and Fatty Acid Oxidation Pathways

Foods
Excessive lipid accumulation in the liver can cause NAFLD, leading to chronic liver injury. To relieve liver lipid accumulation by dietary proteins, this study used oleic acid (OA) induction to establish a stable in vitro LO2 cell lipid accumulation ...
Bing Fang, Jie Luo, Zhengwu Cui, Rong Liu, Pengjie Wang, Jian Zhang   +5 more
doaj   +1 more source

Ginsenoside Rb1 Enhances Atherosclerotic Plaque Stability by Improving Autophagy and Lipid Metabolism in Macrophage Foam Cells

Frontiers in Pharmacology, 2017
Atherosclerosis (AS) is a lipid-driven disease in which macrophage foam cells play a critical role by increasing vascular lipid accumulation and contributing to plaque instability. Ginsenoside Rb1 (Rb1), the most abundant active component of ginseng, has
Lei Qiao, Xue Zhang, Xue Zhang, Minghao Liu, Xiaoling Liu, Mei Dong, Jing Cheng, Xinyu Zhang, Chungang Zhai, Yu Song, Huixia Lu, Wenqiang Chen   +11 more
doaj   +1 more source

The lncRNA Gm15622 stimulates SREBP-1c expression and hepatic lipid accumulation by sponging the miR-742-3p in mice[S]

Journal of Lipid Research, 2020
Excessive lipid deposition is a hallmark of NAFLD. Although much has been learned about the enzymes and metabolites involved in NAFLD, few studies have focused on the role of long noncoding RNAs (lncRNAs) in hepatic lipid accumulation.
Minjuan Ma, Rui Duan, Lulu Shen, Mengting Liu, Yaya Ji, Haoze Zhou, Changxian Li, Tingming Liang, Xiangcheng Li, Li Guo   +9 more
semanticscholar   +1 more source