Alpha-Synuclein Continues to Enhance SNARE-Dependent Vesicle Docking at Exorbitant Concentrations
Frontiers in Neuroscience, 2019 Recently, Parkinson’s disease-associated α-synuclein (αS) has emerged as an important regulator for SNARE-dependent vesicle fusion. However, it is controversial if excessive accumulation of αS, even in the absence of aggregation, impairs ...
Brenden J. D. Hawk +2 more
doaj +1 more source
Molecular Dynamics Investigation of Lipid-Specific Interactions with a Fusion Peptide
BiomoleculesThe HIV-1 fusion peptide, which is a short hydrophobic peptide from the gp41 coat glycoprotein that participates in the infection of a cell, interacts with model lipid bilayer membranes in a concentration-dependent manner.
William T. Heller
doaj +1 more source
The Thermodynamics of Endosomal Escape and DNA Release from Lipoplexes [PDF]
Phys. Chem. Chem. Phys. 18, 2591 (2016), 2015 Complexes of cationic and neutral lipids and DNA (lipoplexes) are emerging as promising vectors for gene therapy applications. Their appeal stems from their non pathogenic nature and the fact that they self-assemble under conditions of thermal equilibrium. Lipoplex adhesion to the cell plasma membrane initiates a three-stage process termed transfection,
arxiv +1 more source
Pathway for insertion of amphiphilic nanoparticles into defect-free lipid bilayers from atomistic molecular dynamics simulations [PDF]
, 2015 Gold nanoparticles (NPs) have been increasingly used in biological applications that involve potential contact with cellular membranes. As a result, it is essential to gain a physical understanding of NP-membrane interactions to guide the design of next ...
Alexander-Katz, Alfredo +1 more
core +2 more sources
Vesicle Fusion Observed by Content Transfer across a Tethered Lipid Bilayer [PDF]
Biophysical Journal, 2011 Synaptic transmission is achieved by exocytosis of small, synaptic vesicles containing neurotransmitters across the plasma membrane. Here, we use a DNA-tethered freestanding bilayer as a target architecture that allows observation of content transfer of individual vesicles across the tethered planar bilayer.
Rawle, Bob +4 more
openaire +3 more sources
Dependence of protein-induced lipid bilayer deformations on protein shape [PDF]
, 2022 Membrane proteins typically deform the surrounding lipid bilayer membrane, which can play an important role in the function, regulation, and organization of membrane proteins. Membrane elasticity theory provides a beautiful description of protein-induced lipid bilayer deformations, in which all physical parameters can be directly determined from ...
arxiv +1 more source
Role of the fast kinetics of pyroglutamate-modified amyloid-β oligomers in membrane binding and membrane permeability. [PDF]
, 2014 Membrane permeability to ions and small molecules is believed to be a critical step in the pathology of Alzheimer's disease (AD). Interactions of oligomers formed by amyloid-β (Aβ) peptides with the plasma cell membrane are believed to play a fundamental
Gillman, Alan L +6 more
core +1 more source
Frontiers in Molecular Biosciences, 2022 Hemagglutinin (HA) mediated fusion of influenza virus envelope with host lipid membrane is a critical step warrantying virus entry to the cell. Despite tremendous advances in structural biology methods, the knowledge concerning the details of HA2 subunit
Michal Michalski, Piotr Setny
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Rapid Membrane Fusion of Individual Virus Particles with Supported Lipid Bilayers [PDF]
Biophysical Journal, 2007 Many enveloped viruses employ low-pH-triggered membrane fusion during cell penetration. Solution-based in vitro assays in which viruses fuse with liposomes have provided much of our current biochemical understanding of low-pH-triggered viral membrane fusion.
Dominic Scimeca +3 more
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Coiled-Coil Formation on Lipid Bilayers—Implications for Docking and Fusion Efficiency [PDF]
Biophysical Journal, 2012 Coiled-coil formation of four different oligopeptides was characterized in solution, on hydrogels, and on membranes by employing circular dichroism spectroscopy, surface plasmon resonance spectroscopy, attenuated total reflection infrared spectroscopy, and ellipsometry.
Paehler, Gesa +3 more
openaire +4 more sources