Engineering Phosphatidylserine Containing Asymmetric Giant Unilamellar Vesicles
MembranesThe plasma membrane lipid distribution is asymmetric, with several anionic lipid species located in its inner leaflet. Among these, phosphatidylserine (PS) plays a crucial role in various important physiological functions.
Jake McDonough +5 more
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Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase
eLife, 2019 The lipid distribution of plasma membranes of eukaryotic cells is asymmetric and phospholipid scramblases disrupt this asymmetry by mediating the rapid, nonselective transport of lipids down their concentration gradients.
Maria E Falzone +10 more
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Formation of Supported Lipid Bilayers by Vesicle Fusion: Effect of Deposition Temperature
Langmuir, 2014 We have investigated the effect of deposition temperature on supported lipid bilayer formation via vesicle fusion. By using several complementary surface-sensitive techniques, we demonstrate that despite contradicting literature on the subject, high-quality bilayers can be formed below the main phase-transition temperature of the lipid.
Lind, Tania Kjellerup +2 more
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Understanding the formation of supported lipid bilayers via vesicle fusion—A case that exemplifies the need for the complementary method approach (Review) [PDF]
, 2016 Tania Kjellerup Lind, Marité Cárdenas
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Novel broad spectrum virucidal molecules against enveloped viruses.
PLoS ONE, 2018 Viral infections are an important cause of death worldwide. Unfortunately, there is still a lack of antiviral drugs or vaccines for a large number of viruses, and this represents a remarkable challenge particularly for emerging and re-emerging viruses ...
Valeria Cagno +10 more
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Asymmetric membranes resulting from the fusion of two black lipid bilayers
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1974 Abstract When two black lipid bilayers are brought into close contact in the presence of divalent ions they interact, a process termed “fusion”. The resulting structure is suggested to be another bilayer with a multitude of intercalated solvent lenses and micelles.
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Effect of the S2’ site cleavage on SARS-CoV-2 spike
Nature CommunicationsSARS-CoV-2 initiates infection of host cells by fusing its envelope lipid bilayer with the cell membrane. To overcome kinetic barriers for membrane fusion, the virus-encoded spike (S) protein refolds from a metastable prefusion state to a lower energy ...
Wei Shi +10 more
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Stringent 3Q·1R Composition of the SNARE 0-Layer Can Be Bypassed for Fusion by Compensatory SNARE Mutation or by Lipid Bilayer Modification [PDF]
, 2007 Rutilio A. Fratti +3 more
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Fusion Peptides Promote Formation of Bilayer Cubic Phases in Lipid Dispersions. An X-Ray Diffraction Study [PDF]
, 2013 Boris Tenchov +2 more
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