Results 121 to 130 of about 1,416,231 (245)

A new investigation of nonalcoholic fatty liver disease: Effects of hypoxia on mitochondrial function and lipid droplet autophagy.

PLoS ONE
An expanding body of research has highlighted the intimate connection between nonalcoholic fatty liver disease (NAFLD) and the dysregulation of hepatic lipid droplet autophagy as well as mitochondrial function.
Meiyuan Tian, Yaogang Zhang, Zhe Liu, Na Zhao, Dengliang Huang, Jing Hou, Li Sun, Yuan Jiang, Guangcun Zhang, Yanyan Ma   +9 more
doaj   +1 more source

Spatiotemporal Coupling of the Hepatitis C Virus Replication Cycle by Creating a Lipid Droplet- Proximal Membranous Replication Compartment.

Cell Reports, 2019
The hepatitis C virus (HCV) is a major cause of chronic liver disease, affecting around 71 million people worldwide. Viral RNA replication occurs in a membranous compartment composed of double-membrane vesicles (DMVs), whereas virus particles are thought
Ji-Young Lee, M. Cortese, U. Haselmann, Keisuke Tabata, I. Romero-Brey, Charlotta Funaya, N. Schieber, Yu Qiang, Marie Bartenschlager, S. Kallis, Christian Ritter, K. Rohr, Y. Schwab, A. Ruggieri, R. Bartenschlager   +14 more
semanticscholar   +1 more source

A monolithic fluid-structure interaction formulation for solid and liquid membranes including free-surface contact

, 2018
A unified fluid-structure interaction (FSI) formulation is presented for solid, liquid and mixed membranes. Nonlinear finite elements (FE) and the generalized-alpha scheme are used for the spatial and temporal discretization.
Luginsland, Tobias, Sauer, Roger A.
core   +1 more source

Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation

Cells, 2019
Lipid droplets (LDs) serve as energy rich reservoirs and have been associated with apolipoprotein E (APOE) and neurodegeneration. The E4 allele of APOE (E4) is the strongest genetic risk factor for the development of late onset Alzheimer’s disease (AD ...
Brandon C Farmer, J. Kluemper, Lance A. Johnson   +2 more
semanticscholar   +1 more source

HILPDA Regulates Lipid Metabolism, Lipid Droplet Abundance, and Response to Microenvironmental Stress in Solid Tumors

Molecular Cancer Research, 2019
Accumulation of lipid droplets has been observed in an increasing range of tumors. However, the molecular determinants of this phenotype and the impact of the tumor microenvironment on lipid droplet dynamics are not well defined.
M. VandeKopple, Jinghai Wu, Erich N Auer, A. Giaccia, N. Denko, I. Papandreou   +5 more
semanticscholar   +1 more source

Unravelling the effect of droplet size on lipid oxidation in O/W emulsions by using microfluidics

Scientific Reports
Lipid oxidation in emulsions is hypothesised to increase with decreasing droplet size, as this increases the specific oil–water interfacial area, where lipid oxidation is expected to be initiated.
Sten ten Klooster, Vincent J. P. Boerkamp, Marie Hennebelle, John P. M. van Duynhoven, Karin Schroën, Claire C. Berton-Carabin   +5 more
doaj   +1 more source

Lipid droplet detection in histopathological images using reinforcement learning

Biotechnology & Biotechnological Equipment
The identification and analysis of lipid droplets in pathological images are pivotal owing to the variations in their size, shading and shape. The development of an artificial intelligence-based automatic detection method can facilitate the analysis of ...
Yoshitomi Harada, Haruto Nishida, Keiko Matsuura   +2 more
doaj   +1 more source

Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger Lipophagy and Drive Virus Production.

Cell Host and Microbe, 2018
Ubiquitylation is one of the most versatile protein post-translational modifications and is frequently altered during virus infections. Here we employed a functional proteomics screen to identify host proteins that are differentially ubiquitylated upon ...
Jingshu Zhang, Y. Lan, Ming Yuan Li, M. Lamers, Maxime Fusade-Boyer, Elizabeth J. Klemm, C. Thiele, J. Ashour, Sumana Sanyal   +8 more
semanticscholar   +1 more source

Belousov-Zhabotinsky droplet mixing on-chip for chemical computing applications

, 2013
Without an imposed physical structure, even the most complex chemistries are limited in their ability to process information. For example, the Belousov-Zhabotinsky (BZ) oscillating reaction has been shown to have information procession potential, but ...
de Planque, Maurits R.R., Jones, Gareth, King, Philip H., Morgan, Hywel, Zauner, Klaus-Peter   +4 more
core  

Stability analysis of polarized domains

, 1997
Polarized ferrofluids, lipid monolayers and magnetic bubbles form domains with deformable boundaries. Stability analysis of these domains depends on a family of nontrivial integrals. We present a closed form evaluation of these integrals as a combination
A. A. Thiele, A. A. Thiele, A. G. Boudouvis, A. O. Tsebers, D. P. Jackson, H. M. McConnell, H. M. McConnell, José A. Miranda, K. Y. C. Lee, Michael Widom, R. E. Goldstein, R. E. Rosensweig, S. A. Langer   +12 more
core   +2 more sources