Lipid Droplets in Neurodegenerative Disorders [PDF]
Frontiers in Neuroscience, 2020 Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to dynamic and functionally active organelles involved in a variety of cellular functions. Studies have now informed significant roles for LDs in cellular signaling, metabolic disease, and inflammation.
Brandon C. Farmer +4 more
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The Phospholipid:Diacylglycerol Acyltransferase Lro1 Is Responsible for Hepatitis C Virus Core-Induced Lipid Droplet Formation in a Yeast Model System. [PDF]
PLoS ONE, 2016 Chronic infection with the hepatitis C virus frequently induces steatosis, which is a significant risk factor for liver pathogenesis. Steatosis is characterized by the accumulation of lipid droplets in hepatocytes.
Shingo Iwasa +7 more
doaj +1 more source
Organellar Contacts of Milk Lipid Droplets
Contact, 2020 Milk-secreting epithelial cells of the mammary gland are functionally specialized for the synthesis and secretion of large quantities of neutral lipids, a major macronutrient in milk from most mammals.
Jenifer Monks +2 more
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Dynamics of Vesicle Formation from Lipid Droplet: Mechanism and Controllability
, 2009 A coarse-grained model developed by Marrink et al. [J. Phys. Chem. B 111, 7812 (2007)] is applied to investigate vesiculation of lipid [dipalmitoylphosphatidylcholine (DPPC)] droplets in water.
Helfrich W., Xuehao He, Zilu Wang
core +1 more source
Lipid Droplets in Cancer [PDF]
, 2020 AbstractLipid droplets have a unique structure among organelles consisting of a dense hydrophobic core of neutral lipids surrounded by a single layer of phospholipids decorated with various proteins. Often labeled merely as passive fat storage repositories, they in fact have a remarkably dynamic life cycle. Being formed within the endoplasmic reticulum
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COPI complex is a regulator of lipid homeostasis.
PLoS Biology, 2008 Lipid droplets are ubiquitous triglyceride and sterol ester storage organelles required for energy storage homeostasis and biosynthesis. Although little is known about lipid droplet formation and regulation, it is clear that members of the PAT (perilipin,
Mathias Beller +6 more
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Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance
Nature CommunicationsHow cells coordinate cell cycling with cell survival and death remains incompletely understood. Here, we show that cell cycle arrest has a potent suppressive effect on ferroptosis, a form of regulated cell death induced by overwhelming lipid peroxidation
Hyemin Lee +16 more
semanticscholar +1 more source
Porcine SCD1 Regulates Lipid Droplet Number via CLSTN3B in PK15 Cells
AnimalsFat deposition plays a key role in determining porcine meat quality traits, with lipid droplets serving as critical organelles for lipid storage in adipose tissue. Inhibiting lipid droplet biogenesis disrupts the lipid storage capacity of adipocytes. The
Wenzhe Bai +7 more
doaj +1 more source
A new fluorescence-based method identifies protein phosphatases regulating lipid droplet metabolism.
PLoS ONE, 2010 In virtually every cell, neutral lipids are stored in cytoplasmic structures called lipid droplets (LDs) and also referred to as lipid bodies or lipid particles.
Bruno L Bozaquel-Morais +4 more
doaj +1 more source
Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis [PDF]
, 2015 This work was supported by a Merit Scholarship from the Islamic Development Bank (to M.M.U.T.), The Agency for Science, Technology and Research, Singapore (A*STAR) (M.F.M.S), the Medical Research Council (MRC) [NIRG GO800203 and Research Grant MR/L002620/
Edwardson, J Michael +4 more
core +2 more sources