Results 31 to 40 of about 1,446,619 (399)
Astrocytes in stress accumulate lipid droplets
Glia, 2021 When the brain is in a pathological state, the content of lipid droplets (LDs), the lipid storage organelles, is increased, particularly in glial cells, but rarely in neurons.
T. Smolič +11 more
semanticscholar +1 more source
Nature Communications, 2021 Upon starvation, cells rewire their metabolism, switching from glucose-based metabolism to mitochondrial oxidation of fatty acids, which require the transfer of FAs from lipid droplets (LDs) to mitochondria at mitochondria−LD membrane contact sites (MCSs)
Jingru Wang +5 more
semanticscholar +1 more source
eLife, 2021 Cytoplasmic lipid droplets are highly dynamic storage organelles that are critical for cellular lipid homeostasis. While the molecular details of lipid droplet dynamics are a very active area of investigation, this work has been primarily performed in ...
Meredith H Wilson +2 more
doaj +1 more source
Lipid droplets and lipid mediators in viral infection and immunity
FEMS Microbiology Reviews, 2021 Lipid droplets (LDs) contribute to key pathways important for the physiology and pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids, protein sequestration, removal of toxic lipids and cellular communication ...
E. A. Monson +4 more
semanticscholar +1 more source
Lipid droplets: platforms with multiple functions in cancer hallmarks
Cell Death and Disease, 2020 Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play important roles in cell signaling, lipid metabolism, membrane trafficking, and the production of inflammatory mediators.
A. L. S. Cruz +4 more
semanticscholar +1 more source
Functions of Stress-Induced Lipid Droplets in the Nervous System
Frontiers in Cell and Developmental Biology, 2022 Lipid droplets are highly dynamic intracellular organelles that store neutral lipids such as cholesteryl esters and triacylglycerols. They have recently emerged as key stress response components in many different cell types. Lipid droplets in the nervous
Eva Islimye, Victor Girard, A. Gould
semanticscholar +1 more source
Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus [PDF]
, 2014 In hepatitis C virus infection, replication of the viral genome and virion assembly are linked to cellular metabolic processes. In particular, lipid droplets, which store principally triacylglycerides (TAGs) and cholesterol esters (CEs), have been ...
Hague, Charlotte V. +4 more
core +1 more source
Journal of Lipid Research, 2005 Hydrolysis of intracellular cholesteryl esters (CEs) represents the first step in the removal of cholesterol from lipid-laden foam cells associated with atherosclerotic lesions.
Bin Zhao +4 more
doaj +1 more source
The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells [PDF]
, 2016 Dietary overload of toxic, free metabolic intermediates leads to disrupted insulin signalling and fatty liver disease. However, it was recently reported that this pathway might not be universal: depletion of histone deacetylase (HDAC) enhances insulin ...
Enejder, Annika +6 more
core +1 more source
Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegans
iScience, 2023 Summary: In several long-lived Caenorhabditis elegans strains, such as insulin/IGF-1 receptor daf-2 mutants, enhanced proteostatic mechanisms are accompanied by elevated intestinal lipid stores, but their role in longevity is unclear.
Anita V. Kumar +11 more
doaj +1 more source