Results 41 to 50 of about 926,787 (298)
Abrogation of lysophosphatidic acid receptor 1 ameliorates murine vasculitis
Arthritis Research & Therapy, 2019 Background Lysophosphatidic acid (LPA), generated by autotaxin (ATX), is a bioactive lipid mediator that binds to the receptors (LPA1–6), and serves as an important mediator in inflammation.
Chie Miyabe +10 more
doaj +1 more source
Lipid Mediators in the Resolution of Inflammation [PDF]
Cold Spring Harbor Perspectives in Biology, 2014 Mounting of the acute inflammatory response is crucial for host defense and pivotal to the development of chronic inflammation, fibrosis, or abscess formation versus the protective response and the need of the host tissues to return to homeostasis. Within self-limited acute inflammatory exudates, novel families of lipid mediators are identified, named ...
Charles N, Serhan +3 more
openaire +2 more sources
Lipid mediators in diabetic nephropathy [PDF]
Fibrogenesis & Tissue Repair, 2014 The implications of lipid lowering drugs in the treatment of diabetic nephropathy have been considered. At the same time, the clinical efficacy of lipid lowering drugs has resulted in improvement in the cardiovascular functions of chronic kidney disease (CKD) patients with or without diabetes, but no remarkable improvement has been observed in the ...
Srivastava, Swayam +3 more
openaire +2 more sources
Solid Lipid Nanoparticles: A Potential Approach for Dermal Drug Delivery [PDF]
, 2014 Solid lipid nanoparticles (SLNs) have attracted increasing attention during recent years. Due to their unique size dependent properties, lipid nanoparticles offer possibilities to develop new therapeutics.
Conway, Barbara R +3 more
core +1 more source
Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner
Journal of Lipid Research, 2006 Sphingosine 1-phosphate (S1P) is accumulated in platelets and released on stimulation by thrombin or Ca2+. Thrombin-stimulated S1P release was inhibited by staurosporin, whereas Ca2+-stimulated release was not.
Nobuyoshi Kobayashi +6 more
doaj +1 more source
Molecular Metabolism, 2022 Objective: Physical activity has been shown to reduce the risk of CVD mortality in large-cohort longitudinal studies; however, the mechanisms underpinning the beneficial effects of exercise remain incompletely understood.
Ernesto Pena Calderin +7 more
doaj +1 more source
Communicating with the dead: lipids, lipid mediators and extracellular vesicles [PDF]
Biochemical Society Transactions, 2018 Apoptosis is a key event in the control of inflammation. However, for this to be successful, dying cells must efficiently and effectively communicate their presence to phagocytes to ensure timely removal of dying cells. Here, we consider apoptotic cell-derived extracellular vesicles and the role of contained lipids and lipid mediators in ensuring ...
Devitt, Andrew +2 more
openaire +2 more sources
Frontiers in Immunology, 2012 Acute inflammation and its resolution are essential processes for tissue protection and homeostasis. Once thought to be a passive process, the resolution of inflammation is now shown to involve active biochemical programs that enable inflamed tissues to ...
Yosuke eIsobe +3 more
doaj +1 more source
Frontiers in Immunology, 2023 Activation of pancreatic stellate cells (PSCs) to cancer-associated fibroblasts (CAFs) is responsible for the extensive desmoplastic reaction observed in PDAC stroma: a key driver of pancreatic ductal adenocarcinoma (PDAC) chemoresistance leading to poor
Gabriel A. Aguirre +4 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source