Results 41 to 50 of about 324,910 (305)

Proresolving lipid mediators enhance PMN-mediated bacterial clearance [PDF]

Proceedings of the National Academy of Sciences, 2020
Host responses to bacterial infection are protective, yet without timely resolution they can lead to uncontrolled infection, with systemic engagement and multiple organ failure. In PNAS, Sekheri et al. (1) report the property of specific lipid mediators to counteract the delay tactics of bacterial DNA released from proliferating or dying bacteria as ...
Lucy V. Norling, Mauro Perretti
openaire   +2 more sources

Eicosapentaenoic Acid Influences the Lipid Profile of an In Vitro Psoriatic Skin Model Produced with T Cells

Biomolecules, 2023
Psoriasis is a skin disease characterized by epidermal hyperplasia and an inappropriate activation of the adaptive immunity. A dysregulation of the skin’s lipid mediators is reported in the disease with a predominance of the inflammatory cascade derived ...
Sophie Morin, Andréa Tremblay, Elizabeth Dumais, Pierre Julien, Nicolas Flamand, Roxane Pouliot   +5 more
doaj   +1 more source

Spartin-mediated lipid transfer facilitates lipid droplet turnover

Proceedings of the National Academy of Sciences, 2023
AbstractLipid droplets (LDs) are organelles critical for energy storage and membrane lipid homeostasis, whose number and size are carefully regulated in response to cellular conditions. The molecular mechanisms underlying lipid droplet biogenesis and degradation, however, are not well understood.
Neng Wan, Zhouping Hong, Matthew A. H. Parson, Justin L. Korfhage, John E. Burke, Thomas J. Melia, Karin M. Reinisch   +6 more
openaire   +3 more sources

Occurrence and biological activity of palmitoleic acid isomers in phagocytic cells

Journal of Lipid Research, 2018
Recent studies have highlighted the role of palmitoleic acid [16:1n-7 (cis-9-hexadecenoic acid)] as a lipid hormone that coordinates cross-talk between liver and adipose tissue and exerts anti-inflammatory protective effects on hepatic steatosis and ...
Alma M. Astudillo, Clara Meana, Carlos Guijas, Laura Pereira, Patricia Lebrero, María A. Balboa, Jesús Balsinde   +6 more
doaj   +1 more source

Effects of flaxseed supplementation on omega-6 to omega-3 fatty acid ratio, lipid mediator profile, proinflammatory cytokines and stress indices in laying hens

Journal of Applied Animal Research, 2021
Although polyunsaturated fatty acids (PUFAs) have gained attention because of their physiological effects on inflammation and stress, their derivatives, termed lipid mediators, have been rarely examined, especially in laying hens. In this study, we aimed
Sang-Mok Lee, Hee Kyum Kim, Ho-Bin Lee, Oh-Dae Kwon, Eun-Bi Lee, Jin-Duck Bok, Chong-Su Cho, Yun-Jaie Choi, Sang-Kee Kang   +8 more
doaj   +1 more source

Fracture healing and lipid mediators [PDF]

BoneKEy Reports, 2014
Lipid mediators regulate bone regeneration during fracture healing. Prostaglandins and leukotrienes are well-known lipid mediators that regulate inflammation and are synthesized from the Ω-6 fatty acid, arachidonic acid. Cyclooxygenase (COX-1 or COX-2) and 5-lipoxygenase (5-LO) catalyze the initial enzymatic steps in the synthesis of prostaglandins and
J Patrick, O'Connor, Michaele B, Manigrasso, Brian D, Kim, Sangeeta, Subramanian   +3 more
openaire   +2 more sources

Lipid mediators and allergic diseases [PDF]

Annals of Allergy, Asthma & Immunology, 2013
To review the basic science and translational relevance of lipid mediators in the pathobiology of allergic diseases.PubMed was searched for articles using the key terms lipid mediator, prostaglandin, prostanoid, leukotriene, thromboxane, asthma, and allergic inflammation.Articles were selected based on their relevance to the goals of this review ...
Laura B, Fanning, Joshua A, Boyce
openaire   +2 more sources

The ethanolamide metabolite of DHA, docosahexaenoylethanolamine, shows immunomodulating effects in mouse peritoneal and RAW264.7 macrophages: evidence for a new link between fish oil and inflammation [PDF]

, 2011
Several mechanisms have been proposed for the positive health effects associated with dietary consumption of long-chain n-3 PUFA (n-3 LC-PUFA) including DHA (22 : 6n-3) and EPA (20 : 5n-3).
Attya, M., Balvers, M.G.J., Gabriele, B., Gruppen, H., Meijerink, J., Plastina, P., Poland, M.C.R., Vincken, J.P., Witkamp, R.F.   +8 more
core   +3 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease [PDF]

, 2014
Background: There are plausible mechanisms for how dietary docosahexaenoic acid (DHA), an n−3 polyunsaturated fatty acid, could prevent Crohn's disease (CD).
Abraham, Ananthakrishnan, Ananthakrishnan, Ananthakrishnan, Arita, Bartoli, Belluzzi, Bingham, Burdge, Chan, Charpentier, Corey, Depner, Feagan, Fritsche, Goldbohm, Goldman, Hommes, Jostins, Kaaks, Levy, Novak, Rao, Riboli, Rodriguez-Lagunas, Sakamoto, Salem, Samuelsson, Serhan, Serini, Shivananda, Tjonneland, Turner, Watanabe, Weylandt, Yaqoob   +35 more
core   +1 more source