Results 221 to 230 of about 363,241 (308)

PhospholipaseA2VI mediates the lipid peroxidation-ferroptosis axis to regulate rooster sperm motility. [PDF]

Poult Sci
Li J, Liu P, Zhang J, Tian Y, Sun G, Kang X, Li D, Gu Y.   +7 more
europepmc   +1 more source

Influence of the lysosomal elastase inhibitor eglin on development of interstitial lung edema in E. coli bacteremia in pigs [PDF]

, 1987
Jochum, Marianne, Redl, H., Schlag, G., Siebeck, Matthias, Thetter, O., Welter, H. F.   +5 more
core  

CRISPR/Cas9‐Based Vanadium MXene‐Free Radical Spatiotemporally Controlled Nanoreactor for Photothermal‐Induced Multi‐Effect Synergistic Antitumor Therapy

Advanced Science, EarlyView.
In this study, a MXene‐based V4C3 nanoplatform, VARH, was constructed, which achieved a photothermal conversion efficiency of 44.21% in the NIR‐II window. This platform integrated photothermal therapy, chemodynamic therapy, and thermodynamic therapy with CRISPR/Cas9‐mediated heat shock protein 90 knock‐out technology.
Zi‐Jian Huang, Feng‐Ming Li, Yi‐Fan Tu, Ke‐Ke Feng, Cheng‐Lei Li, Shi‐Cheng Tian, Yong‐Shan Hu, Jing‐Wei Shao, Zhen‐Hua Liu   +8 more
wiley   +1 more source

Reactive oxygen species and peroxynitrite in acetaminophen-induced liver injury: Lipid peroxidation and ferroptosis-like cell death. [PDF]

Ferroptosis Oxid Stress
Jaeschke H, Ramachandran A.
europepmc   +1 more source

Reaction pattern of alveolar cells in the posttraumatic lung failure [PDF]

, 1987
Jochum, Marianne, Joka, T., Kreutzfelder, E., Oberste-Beulmann, S., Obertacke, U., Pison, V., Redl, H., Schlag, G., Schönfeld, W., Zilow, G.   +9 more
core  

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Lipotoxicity, lipid peroxidation and ferroptosis: a dilemma in cancer therapy. [PDF]

Cell Biol Toxicol
Ma C, Hu H, Liu H, Zhong C, Wu B, Lv C, Tian Y.   +6 more
europepmc   +1 more source

SIRT1 Prevents Ferroptosis in Corneal Epithelial Cells by Enhancing HIF1α Protein Stability in Dry Eye Disease

Advanced Science, EarlyView.
Hyperosmotic stress drives ferroptosis in corneal epithelium via SIRT1 downregulation. This work demonstrates that SIRT1 activation stabilizes HIF1α, which transcriptionally upregulates GPX4 to inhibit lipid peroxidation and cell death. The identified SIRT1/HIF1α/GPX4 axis reveals a novel defense mechanism and potential therapy for dry eye disease ...
Lili Lian, Zhenmin Le, Xuanqiao Ye, Zimo Wang, Jiuxiao Li, Chenyu Dong, Yetao Shen, Jiazheng Li, Yueping Ren, Xiaoyin Ma, Wei Chen, Qinxiang Zheng   +11 more
wiley   +1 more source

Reinforcing Calcium Overload via Inflammation‐Mediated Targeting to Amplify Pyroptosis and Antitumor Immunity

Advanced Science, EarlyView.
A neutrophil‐membrane‐camouflaged nanoplatform (RC@NMVs) exploits tumor inflammation to target and accumulate in tumors. Intracellular Ca2+ overload is triggered via lysosomal CaP dissolution and Ru red‐mediated Ca2+ channel blockade, synergistically inducing gasdermin‐mediated pyroptosis.
Yingying Liu, Yang Liu, Qin Fan, Jinqiao Zhang, Kexin Wen, Boyu Yuan, Xianzhou Cai, Ziliang Dong, Lianhui Wang   +8 more
wiley   +1 more source

SLC25A11-mediated reprogramming of mitochondrial redox state and lipid peroxidation confers NRF2-dependent ferroptosis resistance in biliary tract cancer. [PDF]

Cell Mol Biol Lett
Lin YY, Kuo HH, He ZJ, Chung HY, Kim CH, Pan YR, Wu MJ, Chan MH, Yeh CN, Chiang NJ, Chen MH, Chang YC.   +11 more
europepmc   +1 more source