Results 61 to 70 of about 30,616 (140)

Blocking of DNA specific recognition sites by hydrogen peroxide molecules in the process of ion beam therapy of cancer cells [PDF]

arXiv, 2018
After irradiation of cancer cells in the ion beam therapy method the concentration of hydrogen peroxide in the cell medium grows significantly. But the role of hydrogen peroxide molecules in cancer treatment has not been determined yet. We assume that interaction of peroxide molecules with DNA atomic groups can block the genetic information of the ...
arxiv  

Excessive Lipid Peroxidation in Uterine Epithelium Causes Implantation Failure and Pregnancy Loss

Advanced Science
The uterine epithelium undergoes a dramatic spatiotemporal transformation to enter a receptive state, involving a complex interaction between ovarian hormones and signals from stromal and epithelial cells.
Yafang Lu, Yuhan Shao, Weiwei Cui, Zhaoyu Jia, Qian Zhang, Qing Zhao, Zi‐Jiang Chen, Junhao Yan, Bo Chu, Jia Yuan   +9 more
doaj   +1 more source

Capillary electrophoresis to monitor the oxidative modification of low density lipoproteins

Journal of Lipid Research, 1998
A procedure has been developed that uses high performance capillary electrophoresis to monitor the changes in the electrophoretic mobility of low density lipoproteins (LDL) resulting from Cu2+-catalyzed lipid peroxidation.
Joseph Stocks, Norman E. Miller
doaj  

Instability of Amorphous Oxide Semiconductors via Carrier-Mediated Structural Transition between Disorder and Peroxide State [PDF]

arXiv, 2011
The excited holes occupying the valence band tail states in amorphous oxide semiconductors are found to induce formation of meta-stable O$_2^{2-}$ peroxide defects. The valence band tail states are at least partly characterized by the O-O pp{\sigma}* molecular orbital, and the localized-hole-mediated lattice instability results in the formation of the ...
arxiv  

Research advances of ferroptosis in renal diseases

Linchuang shenzangbing zazhi, 2021
Ferroptosis is characterized by intracellular iron overload and an accumulation of reactive oxygen species leading to lipid peroxidation.Although ferroptosis is more extensively discussed for acute kidney injury and renal cell carcinoma, its potential ...
Yu Peng, Wang Ting-ting, Liu Hong-bao
doaj  

Lipid peroxides induce expression of catalase in cultured vascular cells

Journal of Lipid Research, 2000
Various forms of oxidized low-density lipoproteins (Ox-LDL) are thought to play a major role in the development of atherosclerosis. The lipid components of Ox-LDL present a plethora of proatherogenic effects in in vitro cell culture systems, suggesting ...
Olivier Meilhac, Mimi Zhou, Nalini Santanam, Sampath Parthasarathy   +3 more
doaj  

Methionine-SAM metabolism-dependent ubiquinone synthesis is crucial for ROS accumulation in ferroptosis induction

Nature Communications
Ferroptosis is a cell death modality in which iron-dependent lipid peroxides accumulate on cell membranes. Cysteine, a limiting substrate for the glutathione system that neutralizes lipid peroxidation and prevents ferroptosis, can be converted by cystine
Chaoyi Xia, Pinghui Peng, Wenxia Zhang, Xiyue Xing, Xin Jin, Jianlan Du, Wanting Peng, Fengqi Hao, Zhexuan Zhao, Kejian Dong, Miaomiao Tian, Yunpeng Feng, Xueqing Ba, Min Wei, Yang Wang   +14 more
doaj   +1 more source

Phospho Tensin Homolog in Human and Lipid Peroxides in Peripheral Blood Mononuclear Cells Following Exposure to Flavonoids. [PDF]

J Am Coll Nutr, 2020
Boadi WY, Myles EL, Garcia AS.
europepmc   +1 more source

CRISPR activation screens identify the SWI/SNF ATPases as suppressors of ferroptosis

Cell Reports
Summary: Ferroptosis is an iron-dependent cell death mechanism characterized by the accumulation of toxic lipid peroxides and cell membrane rupture.
Kamakoti P. Bhat, Jinchu Vijay, Caroline K. Vilas, Jyoti Asundi, Jun Zou, Ted Lau, Xiaoyu Cai, Musaddeque Ahmed, Michal Kabza, Julie Weng, Jean-Philippe Fortin, Aaron Lun, Steffen Durinck, Marc Hafner, Michael R. Costa, Xin Ye   +15 more
doaj  

Surufatinib combined with photodynamic therapy induces ferroptosis to inhibit cholangiocarcinoma in vitro and in tumor models

Frontiers in Pharmacology
The curative effect of single therapy for advanced cholangiocarcinoma (CCA) is poor, thus investigating combined treatment strategies holds promise for improving prognosis.
Yun-Peng Huang, Yong-Xiang Wang, Hui Zhou, Zhong-Tao Liu, Zi-Jian Zhang, Li Xiong, Heng Zou, Yu Wen   +7 more
doaj   +1 more source