Results 281 to 290 of about 6,052,075 (348)

Programmed Aggregation of Lipidated Nitrobenzoselenadiazole as a Photo‐Activatable Pyroptosis Inducer

Advanced Healthcare Materials, EarlyView.
This study presents alkylated nitrobenzoselenadiazole (NBSD) photosensitizers that self‐assemble into programmable aggregates, enabling photo‐triggered pyroptosis and enhanced ROS generation. The lead compound, NBSD‐NOc, exhibits superior photodynamic activity, high cellular uptake, and implantable gel compatibility with pH‐responsive release.
Jong Min An, Hyunyoung Choi, Hyo In Kim, Do‐Yeon Kim, Jahyun Kim, Jinbong Park, Junyang Jung, Na Young Jeong, Dokyoung Kim   +8 more
wiley   +1 more source

A Novel Brain Penetrable Nanocarrier Delivers Brain‐Derived Neurotrophic Factor to Treat Alzheimer's Disease

Advanced Healthcare Materials, EarlyView.
A novel blood‐brain barrier‐penetrating terpolymer nanoparticle to deliver brain‐derived neurotrophic factor (BDNF) for the treatment of Alzheimer's disease (AD) is designed. The BDNF‐TPN significantly enhances BDNF accumulation in the brain following intravenous injection, reduces apoptosis and neuroinflammation, thus promoting neuronal survival and ...
Lily Yi Li, Elliya Park, Chunsheng He, Azhar Z. Abbasi, Pei Zhi, Paul E. Fraser, Andrew M. Rauth, Jeffery T. Henderson, Xiao Yu Wu   +8 more
wiley   +1 more source

Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery

Advanced Healthcare Materials, EarlyView.
Nanoparticle (NP) stiffness affects cellular uptake, but its impact on intracellular distribution remains unclear. This study synthesizes silica nanocapsules with varying stiffness, inspired by viral mechanisms, and applies assays to measure cellular uptake and escape efficiency.
Yali Zhang, Yue Hui, Zichao Guo, Dawei Liu, Yun Liu, Huajian Gao, Chun‐Xia Zhao   +6 more
wiley   +1 more source

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Lipid Signaling

, 2019
B. Tu‐Sekine, D. Raben
semanticscholar   +2 more sources

Anoikis in cancer: The role of lipid signaling

Cell Biology International, 2022
Malignantly transformed cells must alter their metabolic status to stay viable in a harsh microenvironment and maintain their ability to invade and spread.
M. Raeisi, Mojtaba Zehtabi, Kobra Velaei, Parisa Fayyazpour, Negar Aghaei, A. Mehdizadeh   +5 more
semanticscholar   +1 more source

Lipid metabolism and lipid signals in aging and longevity

Developmental Cell, 2021
Lipids play crucial roles in regulating aging and longevity. In the past few decades, a series of genetic pathways have been discovered to regulate lifespan in model organisms. Interestingly, many of these regulatory pathways are linked to lipid metabolism and lipid signaling.
Meng C. Wang, Jonathon Duffy, Ayse Sena Mutlu   +2 more
openaire   +2 more sources

Lipid phosphate phosphatases and lipid phosphate signalling

Biochemical Society Transactions, 2005
Mammalian LPPs (lipid phosphate phosphatases) are integral membrane proteins that belong to a superfamily of lipid phosphatases/phosphotransferases. They have broad substrate specificity in vitro, dephosphorylating PA (phosphatidic acid), S1P (sphingosine 1-phosphate), LPA (lysophosphatidic acid) etc.
Pyne, S, Long, J S, Ktistakis, N T, Pyne, N J   +3 more
openaire   +4 more sources