Results 1 to 10 of about 57,903 (321)

Lipidomic Analysis of Archival Pathology Specimens Identifies Altered Lipid Signatures in Ovarian Clear Cell Carcinoma [PDF]

Metabolites, 2021
Cancer metabolism is associated with the enhanced lipogenesis required for rapid growth and proliferation. However, the magnitude of dysregulation of diverse lipid species still requires significant characterization, particularly in ovarian clear cell ...
Sartaj Ahmad Mir, Soon Boon Justin Wong, Kothandaraman Narasimhan, Chua W. L. Esther, Shanshan Ji, Bo Burla, Markus R. Wenk, David S. P. Tan, Anne K. Bendt   +8 more
doaj   +2 more sources

Identification of plasma lipid biomarkers for prostate cancer by lipidomics and bioinformatics [PDF]

, 2012
Background: Lipids have critical functions in cellular energy storage, structure and signaling. Many individual lipid molecules have been associated with the evolution of prostate cancer; however, none of them has been approved to be used as a ...
AA Elgamal, B Brügger, BR Pflug, CG Rogers, Charles Pound, Christina Lynn Addison, D Pchejetski, EF Petricoin, F Bravi, F Teichert, FL Crowe, G Balogh, G Draisma, G Liebisch, H He, HK Min, IM Thompson, IM Thompson, J Ding, J Graessler, J Graessler, J Kurhanewicz, Jeffrey Henegar, Jinghe Mao, JR Graff, Junmei Ai, K Athenstaedt, K Ekroos, K Simons, KA Landers, KH Pietiläinen, KR Keshari, L Zhuang, M Kolak, M Lankinen, M Ollero, Mary R. Roth, MG Swanson, ML Ramírez, O Quehenberger, R Bartz, R Etzioni, R Görke, R Welti, RJ Hamilton, RS Kirby, Ruth Welti, S Devaiah, Steven A. Bigler, TC Gibbs, VD de Mello, VL Freeman, X Han, X Han, X Zhou, Xinchun Zhou, Y Xie, Y Zeng, Youping Deng   +58 more
core   +25 more sources

Evaluation of Normalization Approaches for Quantitative Analysis of Bile Acids in Human Feces

Metabolites, 2022
Quantitative analysis of bile acids in human feces can potentially help to better understand the influence of the gut microbiome and diet on human health.
Hans-Frieder Schött, Esther W. L. Chua, Sartaj Ahmad Mir, Bo Burla, Anne K. Bendt, Markus R. Wenk   +5 more
doaj   +1 more source

Four-dimensional trapped ion mobility spectrometry lipidomics for high throughput clinical profiling of human blood samples

Nature Communications, 2023
The circulatory lipidome is a valuable source for disease markers, but reliable marker discovery requires continuous development of lipidomic methods for large-scale clinical profiling.
Raissa Lerner, Dhanwin Baker, Claudia Schwitter, Sarah Neuhaus, Tony Hauptmann, Julia M. Post, Stefan Kramer, Laura Bindila   +7 more
doaj   +1 more source

Variability of Lipids in Human Milk

Metabolites, 2021
Lipids in breastmilk play a critical role in infant growth and development. However, few studies have investigated sources of variability of both high- and low-abundant milk lipids.
Jayashree Selvalatchmanan, A.V. Rukmini, Shanshan Ji, Alexander Triebl, Liang Gao, Anne K. Bendt, Markus R. Wenk, Joshua J. Gooley, Federico Torta   +8 more
doaj   +1 more source

Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W

Nature Communications, 2021
UBE2W catalyzes the ubiquitination of protein N-termini but its substrate spectrum is largely unknown. Here, the authors discover mAbs selective for peptides derived from N-terminally ubiquitinated proteins, solve the structure of a peptide-bound mAb and
Christopher W. Davies, Simon E. Vidal, Lilian Phu, Jawahar Sudhamsu, Trent B. Hinkle, Scott Chan Rosenberg, Frances-Rose Schumacher, Yi Jimmy Zeng, Carsten Schwerdtfeger, Andrew S. Peterson, Jennie R. Lill, Christopher M. Rose, Andrey S. Shaw, Ingrid E. Wertz, Donald S. Kirkpatrick, James T. Koerber   +15 more
doaj   +1 more source

Chaperone mediated detection of small molecule target binding in cells

Nature Communications, 2020
Quantitative profiling of small molecule-protein binding in cells can aid basic biochemical research and drug discovery. Here, the authors develop the Heat Shock Protein Inhibition Protein Stability Assay (HIPStA) as a high-throughput method to assess ...
Kelvin F. Cho, Taylur P. Ma, Christopher M. Rose, Donald S. Kirkpatrick, Kebing Yu, Robert A. Blake   +5 more
doaj   +1 more source

Lysophosphatidic acid species are associated with exacerbation in chronic obstructive pulmonary disease

BMC Pulmonary Medicine, 2021
Background Chronic obstructive pulmonary disease (COPD) exacerbations are heterogenous and profoundly impact the disease trajectory. Bioactive lipid lysophosphatidic acid (LPA) has been implicated in airway inflammation but the significance of LPA in ...
Qingling Li, Weng Wong, Andrew Birnberg, Arindam Chakrabarti, Xiaoying Yang, David F. Choy, Julie Olsson, Erik Verschueren, Margaret Neighbors, Wendy Sandoval, Carrie M. Rosenberger, Michele A. Grimbaldeston, Gaik W. Tew   +12 more
doaj   +1 more source

Oscillating Glucose Induces the Increase in Inflammatory Stress through Ninjurin-1 Up-Regulation and Stimulation of Transport Proteins in Human Endothelial Cells

Biomolecules, 2023
Clinical data implicate fluctuations of high levels of plasma glucose in cardiovascular diseases. Endothelial cells (EC) are the first cells of the vessel wall exposed to them.
Laura Toma, Gabriela M. Sanda, Camelia S. Stancu, Loredan S. Niculescu, Mina Raileanu, Anca V. Sima   +5 more
doaj   +1 more source

Defining Acute Coronary Syndrome through Metabolomics

Metabolites, 2021
As an emerging platform technology, metabolomics offers new insights into the pathomechanisms associated with complex disease conditions, including cardiovascular diseases.
Arun Surendran, Negar Atefi, Hannah Zhang, Michel Aliani, Amir Ravandi   +4 more
doaj   +1 more source