Results 11 to 20 of about 30,733 (194)
Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W
Nature Communications, 2021 UBE2W catalyzes the ubiquitination of protein N-termini but its substrate spectrum is largely unknown. Here, the authors discover mAbs selective for peptides derived from N-terminally ubiquitinated proteins, solve the structure of a peptide-bound mAb and
Christopher W. Davies +15 more
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Mouse lipidomics reveals inherent flexibility of a mammalian lipidome [PDF]
Scientific Reports, 2021 AbstractLipidomics has become an indispensable method for the quantitative assessment of lipid metabolism in basic, clinical, and pharmaceutical research. It allows for the generation of information-dense datasets in a large variety of experimental setups and model organisms.
Michał A. Surma +5 more
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, 2023 Lipids are historically considered a source of energy and a component of cell membranes. Over the last years, many other functions have been studied, and their importance in our health is well established. For this reason, studies on lipidomics have been increasing in the clinical and food science areas.
Machado, Manuela +3 more
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Variability of Lipids in Human Milk
Metabolites, 2021 Lipids in breastmilk play a critical role in infant growth and development. However, few studies have investigated sources of variability of both high- and low-abundant milk lipids.
Jayashree Selvalatchmanan +8 more
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Chaperone mediated detection of small molecule target binding in cells
Nature Communications, 2020 Quantitative profiling of small molecule-protein binding in cells can aid basic biochemical research and drug discovery. Here, the authors develop the Heat Shock Protein Inhibition Protein Stability Assay (HIPStA) as a high-throughput method to assess ...
Kelvin F. Cho +5 more
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Clinica Chimica Acta, 2020 The present article examines recently published literature on lipids, mainly focusing on research involving glycero-, glycerophospho- and sphingo-lipids. The primary aim is identification of distinct profiles in biologic lipidomic systems by ultra-high-performance liquid chromatography (UHPLC) coupled with mass spectrometry (MS, tandem MS) with ...
Henri F. Avela, Heli Sirén
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BMC Pulmonary Medicine, 2021 Background Chronic obstructive pulmonary disease (COPD) exacerbations are heterogenous and profoundly impact the disease trajectory. Bioactive lipid lysophosphatidic acid (LPA) has been implicated in airway inflammation but the significance of LPA in ...
Qingling Li +12 more
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Defining Acute Coronary Syndrome through Metabolomics
Metabolites, 2021 As an emerging platform technology, metabolomics offers new insights into the pathomechanisms associated with complex disease conditions, including cardiovascular diseases.
Arun Surendran +4 more
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Recent Advances in Lipidomics and Its Application in Food Science [PDF]
Shipin Kexue, 2023 Lipids, one of the important nutrients in foods, are a complex class of biomolecules, which play key roles in the processing of different biomolecules. Lipids affect the quality, nutrition and hygiene of foods, and are directly related to the occurrence ...
WANG Xinhui, SONG Xuejian, ZHANG Dongjie, LI Zhijiang
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Understanding the Lipidome at the Systems Level with lipidomeR [PDF]
, 2020 AbstractLipidomics is one of the fastest-growing areas of molecular profiling in medicine. While increasing amounts of lipidomics data are generated, tools for analyzing and interpreting these data are not equally widely available. We present the lipidomeR -- a tool specifically designed for systematic interpretation of large lipidome-wide studies. The
Cristina Legido-Quigley +2 more
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