Results 61 to 70 of about 30,733 (194)

Lipid Annotator: Towards Accurate Annotation in Non-Targeted Liquid Chromatography High-Resolution Tandem Mass Spectrometry (LC-HRMS/MS) Lipidomics Using a Rapid and User-Friendly Software

Metabolites, 2020
Lipidomics has great promise in various applications; however, a major bottleneck in lipidomics is the accurate and comprehensive annotation of high-resolution tandem mass spectral data.
Jeremy P. Koelmel, Xiangdong Li, Sarah M. Stow, Mark J. Sartain, Adithya Murali, Robin Kemperman, Hiroshi Tsugawa, Mikiko Takahashi, Vasilis Vasiliou, John A. Bowden, Richard A. Yost, Timothy J. Garrett, Norton Kitagawa   +12 more
doaj   +1 more source

Examination of the Brain Mitochondrial Lipidome Using Shotgun Lipidomics [PDF]

, 2009
Contamination from subcellular organelles and myelin has hindered attempts to characterize the lipidome of brain mitochondria. A high degree of mitochondrial purity is required for accurate measurements of the content and molecular species composition of mitochondrial lipids.
Michael A. Kiebish, Xianlin Han, Thomas N. Seyfried   +2 more
openaire   +3 more sources

Lipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress

Journal of Lipid Research, 2012
Liver steatosis can be induced by fasting or high-fat diet. We investigated by lipidomic analysis whether such metabolic states are reflected in the lipidome of hepatocyte lipid droplets (LDs) from mice fed normal chow diet (FED), fasted (FAS), or fed a ...
Chandramohan Chitraju, Martin Trötzmüller, Jürgen Hartler, Heimo Wolinski, Gerhard G. Thallinger, Achim Lass, Rudolf Zechner, Robert Zimmermann, Harald C. Köfeler, Friedrich Spener   +9 more
doaj  

Lipidomics of Huntington’s Disease: A Comprehensive Review of Current Status and Future Directions

Metabolites
Background: Huntington’s disease (HD) is a multifaceted neurological disorder characterized by the progressive deterioration of motor, cognitive, and psychiatric functions.
Ali Yilmaz, Sumeyya Akyol, Nadia Ashrafi, Nazia Saiyed, Onur Turkoglu, Stewart F. Graham   +5 more
doaj   +1 more source

Novel molecular mechanisms by which ginger extract reduces the inflammatory stress in TNFα – activated human endothelial cells; decrease of Ninjurin-1, TNFR1 and NADPH oxidase subunits expression

Journal of Functional Foods, 2018
Dysfunction of endothelial cells (EC) is important for atherosclerosis progression. The aim of this study was to evaluate the potential of ginger extract (GEx), 6-gingerol (6-G) and 6-shogaol (6-Sh) to reverse EC dysfunction and to investigate its ...
Laura Toma, Mina Raileanu, Mariana Deleanu, Camelia S. Stancu, Anca V. Sima   +4 more
doaj  

Plasma proteomics and lipidomics facilitate elucidation of the link between Alzheimer's disease development and vessel wall fragility

Scientific Reports
Proximity Extension Assay (PEA) and mass spectrometry (MS) methodologies were utilized for the proteomic and lipidomic characterization of plasma specimens from patients who developed Alzheimer's disease.
Suzumi M. Tokuoka, Fumie Hamano, Ayako Kobayashi, Shungo Adachi, Tomohiro Andou, Tohru Natsume, Yoshiya Oda   +6 more
doaj   +1 more source

LipidCreator workbench to probe the lipidomic landscape

Nature Communications, 2020
Targeted mass spectrometry enables reproducible and accurate lipid quantification but dedicated software tools to develop targeted lipidomics assays are lacking.
Bing Peng, Dominik Kopczynski, Brian S. Pratt, Christer S. Ejsing, Bo Burla, Martin Hermansson, Peter Imre Benke, Sock Hwee Tan, Mark Y. Chan, Federico Torta, Dominik Schwudke, Sven W. Meckelmann, Cristina Coman, Oliver J. Schmitz, Brendan MacLean, Mailin-Christin Manke, Oliver Borst, Markus R. Wenk, Nils Hoffmann, Robert Ahrends   +19 more
doaj   +1 more source

OTUD6 deubiquitination of RPS7/eS7 on the free 40 S ribosome regulates global protein translation and stress

Nature Communications
Ribosomes are regulated by evolutionarily conserved ubiquitination/deubiquitination events. We uncover the role of the deubiquitinase OTUD6 in regulating global protein translation through deubiquitination of the RPS7/eS7 subunit on the free 40 S ...
Sammy Villa, Pankaj Dwivedi, Aaron Stahl, Trent Hinkle, Christopher M. Rose, Donald S. Kirkpatrick, Seth M. Tomchik, Vishva M. Dixit, Fred W. Wolf   +8 more
doaj   +1 more source

Lipidomics: Developments and applications [PDF]

Journal of Chromatography B, 2009
Lipidomics, defined as the large-scale study of cellular lipids (i.e., the lipidome), has recently emerged as a rapidly expanding research field under the umbrella of systems biology [1–4]. Investigators in lipidomics examine the structures, functions, interactions, and dynamics of cellular lipids, identify their cellular localization (i.e. subcellular
openaire   +3 more sources

Therapeutic efficacy of gut microbiota-derived polyphenol metabolite Urolithin A

Beni-Suef University Journal of Basic and Applied Sciences
Background Despite rising public awareness and improvements in diagnostic and treatment methods, there are adverse effects brought on by drug resistance, an increase in overall treatment costs, and unanticipated side effects from pharmaceuticals.
Shilpa S. Shetty, Sandeep Shetty, N. Suchetha Kumari   +2 more
doaj   +1 more source