Results 141 to 150 of about 11,446 (217)
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.Cisplatin induces oxidative stress and hepatotoxicity, as evidenced by increased serum biomarkers and oxidative damage parameters. Luteolin, derived from Pistacia terebinthus, mitigates these effects by enhancing antioxidant defense systems and improving cell viability in cancer cell lines.
Özge Temiz +9 more
wiley +1 more source
The Landscape of Biomarkers in ICU‐Associated AKI: From Protein Markers to Cell‐Free Nucleic Acids
Journal of Clinical Laboratory Analysis, Volume 40, Issue 17, September 2026.Acute kidney injury (AKI) in critically ill patients—particularly in sepsis—often develops early and is missed by creatinine/urine output–based criteria, delaying risk stratification and timely intervention. This review synthesizes current evidence on established and emerging AKI biomarkers (e.g., NGAL, KIM‐1, [TIMP‐2]·[IGFBP7]) alongside circulating ...
Qi Zhu +10 more
wiley +1 more source
MedComm, Volume 7, Issue 9, September 2026.This study reveals that Lcn2 regulates ferroptosis after ICH via the Keap1/Nrf2 axis. Neuronal Lcn2 deletion reduces lipid peroxidation, restores mitochondrial function, and improves ferroptosis. Keap1 Tyr572Ala mutant acts as a molecular switch whose effects invert with Lcn2 status.
Ya‐nan Dou +14 more
wiley +1 more source
Ferroptosis: Newly Emerged Regulator for Human Disease
MedComm, Volume 7, Issue 9, September 2026.Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao +4 more
wiley +1 more source
DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy
MedComm, Volume 7, Issue 9, September 2026.This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu +6 more
wiley +1 more source
RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities
MedComm, Volume 7, Issue 9, September 2026.RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley +1 more source
Protein Science, Volume 35, Issue 9, September 2026.Abstract The design of proteins with desired biophysical properties, such as high solubility and low aggregation propensity, is crucial for various biotechnological and biomedical applications. While deep learning‐based methods like ProteinMPNN have shown remarkable success in protein sequence design, their direct output may not always exhibit optimal ...
Sacha T. Larda +2 more
wiley +1 more source
Protein Science, Volume 35, Issue 9, September 2026.Abstract Snake envenomation remains a critical global public health challenge. In Brazil, the genus Bothrops is responsible for most accidents, typically resulting in coagulopathy, hemorrhage, and renal failure. Despite its clinical prevalence, the molecular mechanisms driving plasma protein disturbances remain poorly understood.
Bianca C. S. C. de Barros +6 more
wiley +1 more source
Neutrophil Gelatinase-Associated Lipocalin and Interleukin-18 in the Prediction of Acute Kidney Injury in Sepsis Patients [PDF]
Yajing Liu,1 Chunming Li,2 Xiaoya Yang,1 Shufen Guo,1 Zhaobo Cui,1 Hongshan Kang,1 Zhen Ma,1 Huiqing Wang1 1Intensive Care Unit, Hengshui People’s Hospital (Harrison International Peace Hospital), Hengshui, 053000, People’s Republic of China; 2Department
Yang X +7 more
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