Results 1 to 10 of about 2,731 (50)
DAXX drives de novo lipogenesis and contributes to tumorigenesis
Nature Communications, 2023 Cancer cells exhibit elevated lipid synthesis. In breast and other cancer types, genes involved in lipid production are highly upregulated, but the mechanisms that control their expression remain poorly understood.
Iqbal Mahmud +23 more
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Metabolites, 2021 Elucidation of the mechanism of lipogenesis and fat deposition is essential for controlling excessive fat deposition in chicken. Studies have shown that gut microbiota plays an important role in regulating host lipogenesis and lipid metabolism.
Tao Zhang +9 more
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Regulation of lipogenesis by glucocorticoids and insulin in human adipose tissue. [PDF]
PLoS ONE, 2011 Patients with glucocorticoid (GC) excess, Cushing's syndrome, develop a classic phenotype characterized by central obesity and insulin resistance. GCs are known to increase the release of fatty acids from adipose, by stimulating lipolysis, however, the ...
Laura L Gathercole +5 more
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Metabolic Reprogramming in Adipose Tissue During Cancer Cachexia
Frontiers in Oncology, 2022 Cancer cachexia is a disorder of energy balance characterized by the wasting of adipose tissue and skeletal muscle resulting in severe weight loss with profound influence on morbidity and mortality. Treatment options for cancer cachexia are still limited.
Bahar Zehra Camurdanoglu Weber +2 more
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A newly discovered role of metabolic enzyme PCK1 as a protein kinase to promote cancer lipogenesis
Cancer Communications, 2020 Highly active lipogenesis is essential for rapid tumor growth. Sterol regulatory element‐binding protein (SREBP) is a key transcriptional factor for lipogenesis and activated by reduced sterol and oxysterol levels.
Hongfei Jiang +3 more
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Frontiers in Pharmacology, 2022 Background: Non-alcoholic fatty liver disease (NAFLD) is a widespread disease, but no recognized drug treatment exists. Previous studies have shown that artemether (Art) can ameliorate carbon tetrachloride (CCl4)–induced liver fibrosis in mice.
Jia Xu +9 more
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Molecules, 2019 Lipogenesis plays a critical role in the growth and metastasis of tumors, which is becoming an attractive target for anti-tumor drugs. RA-XII, one of the cyclopeptide glycosides isolated from Rubia yunnanensis, exerts anti-tumor effects on liver cancer ...
Di Guo +6 more
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Advanced Science, 2022 Aberrant energy metabolism and cell cycle regulation both critically contribute to malignant cell growth and both processes represent targets for anticancer therapy.
Marcos Rios Garcia +17 more
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Frontiers in Molecular Biosciences, 2021 Krüppel-like factor 10 (KLF10) is a phospho-regulated transcriptional factor involved in many biological processes including lipogenesis; however, the transcriptional regulation on lipogenesis by KLF10 remains largely unclear. Lipogenesis is important in
Yu-Chi Chen +4 more
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Growth Performance, Nutrients Digestibility, Immune System, and Blood Parameters in Broiler Chickens Fed on Diets Supplemented with Cumin (Cuminum cyminum) or Black Cumin (Bunium persicum) Seed Powders [PDF]
Poultry Science Journal, 2020 Effects of dietary inclusion of cumin (CUM) and black cumin (BCUM) powders were investigated on the performance, nutrient digestibility, lipid deposition, and immunocompetence of broiler chickens in a rearing period of 42 days. A total number of 240 male
M Shafiee +4 more
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