Results 11 to 20 of about 16,244 (260)

RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression

Molecules, 2019
Lipogenesis plays a critical role in the growth and metastasis of tumors, which is becoming an attractive target for anti-tumor drugs. RA-XII, one of the cyclopeptide glycosides isolated from Rubia yunnanensis, exerts anti-tumor effects on liver cancer ...
Di Guo, Yurong Wang, Jing Wang, Lihua Song, Zhe Wang, Bingyu Mao, Ninghua Tan   +6 more
doaj   +2 more sources

NAT10 promotes liver lipogenesis in mouse through N4-acetylcytidine modification of Srebf1 and Scap mRNA

Lipids in Health and Disease
Background Metabolic dysfunction associated steatotic liver disease (MASLD), closely linked to excessive lipogenesis, induces chronic liver disease. MASLD often cause other metabolic diseases, such as cardiovascular disease, diabetes and obesity. However,
Zhouqi Wang, Xinxing Wan, Md Asaduzzaman Khan, Lin Peng, Xiaoying Sun, Xuan Yi, Ke Chen   +6 more
doaj   +2 more sources

Role of Lipogenesis Rewiring in Hepatocellular Carcinoma [PDF]

, 2021
Metabolic rewiring is one of the hallmarks of cancer. Altered de novo lipogenesis is one of the pivotal metabolic events deregulated in cancers. Sterol regulatory element-binding transcription factor 1 (SREBP1) controls the transcription of major enzymes
Chen, Xin, Calvisi, Diego F, Zhou, Yi, Tao, Junyan, Calvisi, Diego F., Yi Zhou, Xin Chen, Junyan Tao, Diego F. Calvisi   +8 more
core   +1 more source

Parasitic wasps do not lack lipogenesis

, 2021
Fatty acids are crucial primary metabolites for virtually all creatures on earth. Most organisms thus do not rely exclusively on a nutritional supply containing fatty acids, but have the ability to synthesize fatty acids and triacylglycerides de novo ...
Prager, Lorena, Ruther, Joachim, Pokorny, Tamara, Tamara Pokorny, Lorena Prager, Joachim Ruther   +5 more
core   +1 more source

Role of miR-181c in regulating high-fat diet-induced lipogenesis.

, 2021
This schematic diagram illustrates key steps in the signaling pathway linking a high fat diet with increased lipogenesis. According to this model, high fat triggers lipogenesis by activating IDH1 though SREBF, ACLY, and FASN pathways.
Fernanda Carrizo Velasquez (11419199), Brittany Dunkerly-Eyring (3850909), Kellie L. K. Tamashiro (11812988), Gretha J. Boersma (9024650), Miranda D. Johnson (11812982), Charles Steenbergen (465377), Samarjit Das (561679), Kei Akiyoshi (11812979), Shannon O’Brien (11812985), Atsushi Yamaguchi (121289)   +9 more
core   +1 more source

Derhamnosylmaysin Inhibits Adipogenesis via Inhibiting Expression of PPARγ and C/EBPα in 3T3-L1 Cells

Molecules, 2022
We investigated the effects of derhamnosylmaysin (DM) on adipogenesis and lipid accumulation in 3T3-L1 adipocytes. Our data showed that DM inhibited lipid accumulation and adipocyte differentiation in 3T3-L1 cells.
Hang-Hee Cho, Sun-Hee Jang, Chungkil Won, Chung-Hui Kim, Hong-Duck Kim, Tae Hoon Kim, Jae-Hyeon Cho   +6 more
doaj   +1 more source

SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies

Biomedicines, 2023
Sterol regulatory element-binding proteins (SREBPs) are master transcription factors that play a crucial role in regulating genes involved in the biogenesis of cholesterol, fatty acids, and triglycerides.
Na Li, Xiaodan Li, Yifu Ding, Xiao Liu, Karin Diggle, Tatiana Kisseleva, David A. Brenner   +6 more
doaj   +1 more source

Changes in the sensitivity of lipogenesis in rat hepatocytes to hormones and precursors over the diurnal cycle and during longer-term starvation of donor animals.

Journal of Lipid Research, 1984
In rat hepatocytes freshly isolated from donor rats at different times of the day, the rates of lipogenesis (de novo fatty acid synthesis) varied with a diurnal periodicity.
G F Gibbons, C R Pullinger, O G Björnsson   +2 more
doaj   +1 more source

SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCα transcription in hepatocytes

Journal of Lipid Research, 2003
In chick embryo hepatocytes, activation of acetyl-CoA carboxylase-α (ACCα) transcription by 3,5,3′-triiodothyronine (T3) is mediated by a cis-acting regulatory unit (−101 to −71 bp) that binds the nuclear T3 receptor (TR) and sterol regulatory element ...
Yanqiao Zhang, Liya Yin, F.Bradley Hillgartner   +2 more
doaj   +1 more source

Lipogenesis from amino acids in perfused isolated dog skin

Journal of Lipid Research, 1967
Lipogenesis from amino acids has been studied in isolated perfused dog skin. Uniformly labeled alanine-14C, glycine-14C, isoleucine-14C, leucine-14C, phenylalanine-14C, and valine-14C are all incorporated into the cutaneous lipids, with significant ...
Victor R. Wheatley, George Lipkin, Tae Ha Woo   +2 more
doaj   +1 more source