Results 11 to 20 of about 102,476 (312)

The role of lipid and lipoprotein metabolism in non-alcoholic fatty liver disease [PDF]

, 2017
Due to the epidemic of obesity across the world, nonalcoholic fatty liver disease (NAFLD) has become one of the most prevalent chronic liver disorders in children and adolescents.
Anania, Caterina, Lavorato, Michela, Perla, Francesco Massimo, Prelati, Maurizia, Visicchio, Daniele   +4 more
core   +2 more sources

Regulatory Effects of Metformin, an Antidiabetic Biguanide Drug, on the Metabolism of Primary Rat Adipocytes

Molecules, 2022
Metformin is a biguanide compound commonly applied in humans with type 2 diabetes. The drug affects different tissues, including fat tissue. The direct influence of metformin on cells of fat tissue, i.e., adipocytes, is poorly elucidated.
Tomasz Szkudelski, Klaudia Konieczna, Katarzyna Szkudelska   +2 more
doaj   +1 more source

Derhamnosylmaysin Inhibits Adipogenesis via Inhibiting Expression of PPARγ and C/EBPα in 3T3-L1 Cells

Molecules, 2022
We investigated the effects of derhamnosylmaysin (DM) on adipogenesis and lipid accumulation in 3T3-L1 adipocytes. Our data showed that DM inhibited lipid accumulation and adipocyte differentiation in 3T3-L1 cells.
Hang-Hee Cho, Sun-Hee Jang, Chungkil Won, Chung-Hui Kim, Hong-Duck Kim, Tae Hoon Kim, Jae-Hyeon Cho   +6 more
doaj   +1 more source

Dydrogesterone and norethisterone regulate expression of lipoprotein lipase and hormones-sensitive lipase in human subcutaneous abdominal adipocytes [PDF]

, 2007
Aim: In premenopausal women, hyper-androgenicity is associated with central obesity and an increased cardiovascular risk. We investigated the effects of dydrogesterone (DYD)(a non-androgenic progestogen) and norethisterone (NET)(an androgenic progestogen)
Barnett, A. H., Kumar, Sudhesh, McGee, K. C., McTernan, P. G., Palin, S. L., Sturdee, D. W.   +5 more
core   +1 more source

RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression

Molecules, 2019
Lipogenesis plays a critical role in the growth and metastasis of tumors, which is becoming an attractive target for anti-tumor drugs. RA-XII, one of the cyclopeptide glycosides isolated from Rubia yunnanensis, exerts anti-tumor effects on liver cancer ...
Di Guo, Yurong Wang, Jing Wang, Lihua Song, Zhe Wang, Bingyu Mao, Ninghua Tan   +6 more
doaj   +1 more source

SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies

Biomedicines, 2023
Sterol regulatory element-binding proteins (SREBPs) are master transcription factors that play a crucial role in regulating genes involved in the biogenesis of cholesterol, fatty acids, and triglycerides.
Na Li, Xiaodan Li, Yifu Ding, Xiao Liu, Karin Diggle, Tatiana Kisseleva, David A. Brenner   +6 more
doaj   +1 more source

Changes in the sensitivity of lipogenesis in rat hepatocytes to hormones and precursors over the diurnal cycle and during longer-term starvation of donor animals.

Journal of Lipid Research, 1984
In rat hepatocytes freshly isolated from donor rats at different times of the day, the rates of lipogenesis (de novo fatty acid synthesis) varied with a diurnal periodicity.
G F Gibbons, C R Pullinger, O G Björnsson   +2 more
doaj   +1 more source

Glucocorticoid Receptor and Adipocyte Biology. [PDF]

, 2018
Glucocorticoids are steroid hormones that play a key role in metabolic adaptations during stress, such as fasting and starvation, in order to maintain plasma glucose levels.
Harris, Charles A, Lee, Rebecca A, Wang, Jen-Chywan   +2 more
core   +2 more sources

Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming [PDF]

, 2017
BACKGROUND: The de novo biosynthesis of fatty acids (DNL) through fatty acid synthase (FASN) in adipocytes is exquisitely regulated by nutrients, hormones, fasting, and obesity in mice and humans. However, the functions of DNL in adipocyte biology and in
Czech, Michael P, Danai, Laura V, Guilherme, Adilson, Henchey, Elizabeth, Henriques, Felipe S, Jung, DaeYoung, Kim, Jason K, Lodhi, Irfan J, Pedersen, David J, Semenkovich, Clay F, Shen, Yuefei, Yenilmez, Batuhan   +11 more
core   +4 more sources

SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCα transcription in hepatocytes

Journal of Lipid Research, 2003
In chick embryo hepatocytes, activation of acetyl-CoA carboxylase-α (ACCα) transcription by 3,5,3′-triiodothyronine (T3) is mediated by a cis-acting regulatory unit (−101 to −71 bp) that binds the nuclear T3 receptor (TR) and sterol regulatory element ...
Yanqiao Zhang, Liya Yin, F.Bradley Hillgartner   +2 more
doaj   +1 more source