Results 1 to 10 of about 102,377 (213)

Antibiotic-Induced Dysbiosis of Microbiota Promotes Chicken Lipogenesis by Altering Metabolomics in the Cecum

Metabolites, 2021
Elucidation of the mechanism of lipogenesis and fat deposition is essential for controlling excessive fat deposition in chicken. Studies have shown that gut microbiota plays an important role in regulating host lipogenesis and lipid metabolism.
Tao Zhang, Lan Chen, ZhiMing Pan
exaly   +3 more sources

DAXX drives de novo lipogenesis and contributes to tumorigenesis

Nature Communications, 2023
Cancer cells exhibit elevated lipid synthesis. In breast and other cancer types, genes involved in lipid production are highly upregulated, but the mechanisms that control their expression remain poorly understood.
Iqbal Mahmud, Guimei Tian, Jia Wang, Tarun E. Hutchinson, Brandon J. Kim, Nikee Awasthee, Seth Hale, Chengcheng Meng, Allison Moore, Liming Zhao, Jessica E. Lewis, Aaron Waddell, Shangtao Wu, Julia M. Steger, McKenzie L. Lydon, Aaron Chait, Lisa Y. Zhao, Haocheng Ding, Jian-Liang Li, Hamsa Thayele Purayil, Zhiguang Huo, Yehia Daaka, Timothy J. Garrett, Daiqing Liao   +23 more
doaj   +1 more source

Knocking out central metabolism genes to identify new targets and alternating substrates to improve lipid synthesis in Y. lipolytica

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: Systematic gene knockout studies may offer us novel insights on cell metabolism and physiology. Specifically, the lipid accumulation mechanism at the molecular or cellular level is yet to be determined in the oleaginous yeast Y.
Jiang Zhu, Yang Gu, Yang Gu, Yijing Yan, Jingbo Ma, Jingbo Ma, Xiaoman Sun, Peng Xu, Peng Xu, Peng Xu   +9 more
doaj   +1 more source

PFOS-elicited metabolic perturbation in liver and fatty acid metabolites in testis of adult mice

Frontiers in Endocrinology, 2023
IntroductionMultiple factors can contribute to sub-fecundity, including genetics, lifestyle, and environmental contaminants. PFASs are characterized as “forever chemicals” due to their ubiquitous contamination and their persistence in the environment ...
Wang Ka Lee, Thomas Ka Yam Lam, Hiu Ching Tang, Tsz Chun Ho, Tsz Chun Ho, Hin Ting Wan, Chris Kong Chu Wong, Chris Kong Chu Wong   +7 more
doaj   +1 more source

Chia (Salvia hispanica L.) Flour and Oil Ameliorate Metabolic Disorders in the Liver of Rats Fed a High-Fat and High Fructose Diet

Foods, 2022
We hypothesized that the consumption of chia (Salvia hispanica L.) flour (CF) and chia oil (CO) improves metabolic disorders in the liver of Wistar rats (Rattus norvegicus domestica) fed a high-fat and high-fructose (HFHF) diet.
Luiza de Paula Dias Moreira, Bárbara Nery Enes, Vinícius Parzanini Brilhante de São José, Renata Celi Lopes Toledo, Luiz Carlos Maia Ladeira, Rodrigo Rezende Cardoso, Vinícius da Silva Duarte, Helen Hermana Miranda Hermsdorff, Frederico Augusto Ribeiro de Barros, Hércia Stampini Duarte Martino   +9 more
doaj   +1 more source

Novel Insights into the Differences in Nutrition Value, Gene Regulation and Network Organization between Muscles from Pasture-Fed and Barn-Fed Goats

Foods, 2022
The physiological and biochemical characters of muscles derived from pasture-fed or barn-fed black goats were detected, and RNA-seq was performed to reveal the underlying molecular mechanisms to identify how the pasture feeding affected the nutrition and
Yufeng Yang, Yan Wang, Huiquan Shan, Yalin Zheng, Zeyi Xuan, Jinling Hu, Mingsong Wei, Zhiqiang Wang, Qingyou Liu, Zhipeng Li   +9 more
doaj   +1 more source

Anti-Obesity Effect of Dyglomera^® Is Associated with Activation of the AMPK Signaling Pathway in 3T3-L1 Adipocytes and Mice with High-Fat Diet-Induced Obesity

Molecules, 2022
Dyglomera® is an aqueous ethanol extract of the fruit pods of Dichrostachys glomerata, a Cameroonian spice. Several studies have shown its anti-diabetic and anti-obesity effects. However, the underlying mechanisms for such effects remain unclear.
Hae-Lim Kim, Sung-Kwon Lee, Da-Eun Min, Bong-Keun Choi, Dong-Ryung Lee   +4 more
doaj   +1 more source

Succinate Enhances Lipolysis and Decreases Adipocytes Size in Both Subcutaneous and Visceral Adipose Tissue from High-Fat-Diet-Fed Obese Mice

Foods, 2023
Obesity is a risk factor for many chronic diseases related to the overexpansion of adipose tissue during obesity, leading to metabolic dysfunction and ectopic lipids. Previous studies reported a close relationship between succinate and obesity and its co-
Tengteng Ji, Bing Fang, Ming Zhang, Yaqiong Liu   +3 more
doaj   +1 more source

A newly discovered role of metabolic enzyme PCK1 as a protein kinase to promote cancer lipogenesis

Cancer Communications, 2020
Highly active lipogenesis is essential for rapid tumor growth. Sterol regulatory element‐binding protein (SREBP) is a key transcriptional factor for lipogenesis and activated by reduced sterol and oxysterol levels.
Hongfei Jiang, Lei Zhu, Daqian Xu, Zhimin Lu   +3 more
doaj   +1 more source

Adipose tissue-derived exosomes contribute to obesity-associated liver diseases in long-term high-fat diet-fed mice, but not in short-term

Frontiers in Nutrition, 2023
IntroductionOur study aimed to investigate the changes in hepatic endoplasmic reticulum (ER) stress, inflammation, insulin signaling, and lipid metabolism during the administration of a high-fat diet (HFD) in mice in order to identify correlations ...
Taesang Son, Inae Jeong, Jeongjin Park, Jeongjin Park, Woojin Jun, Woojin Jun, Andre Kim, Ok-Kyung Kim, Ok-Kyung Kim   +8 more
doaj   +1 more source