Results 171 to 180 of about 75,579 (341)

USP28 Promotes Osimertinib Resistance in H1975 NSCLC Cells by Deubiquitinating and Stabilizing SIRT1

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osimertinib (OSI) resistance in non‐small cell lung cancer (NSCLC) remains a significant challenge. This report explored the precise role of USP28 on OSI resistance in NSCLC and identified a functional downstream effector. OSI‐resistant H1975 cells (H1975/OSI) were established by long‐term OSI exposure.
Hu‐Sen Fan, Xiu‐Mei Li, Jia‐Qi Gu, Hai‐Feng Wang, Zhen‐Jiang Zhang   +4 more
wiley   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Succinylation of tumor suppressor PPP2R1A K541 by HAT1 converses the role in modulation of gluconeogenesis/lipogenesis remodeling to display oncogene function. [PDF]

Acta Pharm Sin B
Yang G, Wang Y, Yuan H, Zhang H, Zhao L, Hou C, Lv P, Hao J, Zhang X.   +8 more
europepmc   +1 more source

AMPK‐Dependent Epigenetic Regulation of Metabolism Mediates the Anti‐Cancer Action of Pterostilbene in Hepatocellular Carcinoma

Molecular Nutrition &Food Research, EarlyView.
This study investigates the anti‐cancer effects of pterostilbene (PTS), a naturally occurring dietary phytoestrogen, in a rat model of hepatocellular carcinoma (HCC) induced by a choline‐deficient L‐amino acid‐defined (CDAA) diet. Supplementation with PTS significantly reduces liver steatosis and tumor formation.
Cayla Boycott, Megan Beetch, Katarzyna Lubecka‐Gajewska, Benjamin S. Ramsey, Sandra Torregrosa‐Allen, Bennett D. Elzey, Abigail Cox, Nadia Atallah Lanman, Aline de Conti, Min Li, Mario Ferruzzi, Igor Pogribny, Barbara Stefanska   +12 more
wiley   +1 more source

The Anti-Lipolytic Effect of Insulin in Adipocytes Associates with the Magnitude of Dietary Induced Loss in Body Weight and Fat Mass: A Longitudinal Study. [PDF]

Obes Facts
Andersson DP, Sørensen TIA, Arner P.
europepmc   +1 more source

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.

Cell Metabolism, 2019
J. Lally, Sarani Ghoshal, D. DePeralta, O. Moaven, Lan Wei, Ricard Masia, Derek J. Erstad, N. Fujiwara, Vivian Leong, Vanessa P. Houde, Alexander E. Anagnostopoulos, Alice Wang, Lindsay A. Broadfield, R. Ford, R. Foster, J. Bates, H. Sun, Ting Wang, Henry Liu, A. Ray, A. Saha, J. Greenwood, Sathesh Bhat, G. Harriman, Wenyan Miao, J. Rocnik, W. Westlin, P. Muti, T. Tsakiridis, H. J. Harwood, R. Kapeller, Y. Hoshida, K. Tanabe, G. Steinberg, B. Fuchs   +34 more
semanticscholar   +1 more source

High‐Fat Diet–Wheat Gluten Interactions in HLA‐DQ8 Transgenic Mice

Molecular Nutrition &Food Research, EarlyView.
This study shows how eating a high‐fat diet (HFD) and gluten together influences inflammation, energy balance, and immune responses in HLA‐DQ8 transgenic (DQ8 tg) mice. These findings may provide new insights into how specific dietary components interact to impact metabolic and immune‐related disorders.
Yuri Haneishi, Lucia Treppiccione, Vera Rotondi Aufiero, Francesco Maurano, Saya Watanabe, Diomira Luongo, Giuseppe Mazzarella, Junki Miyamoto, Mauro Rossi   +8 more
wiley   +1 more source

Exosomes combined with extra virgin olive oil reduces lipogenesis, oxidative stress, and inflammation in non-alcoholic fatty liver disease model. [PDF]

PLoS One
Alowaiesh BF, Ibrahim D, Saleh AA, Alhaithloul HAS, Alkhaldi AAM, Abdelfattah-Hassan A.   +5 more
europepmc   +1 more source

Serum insulin and lipogenesis in the suckling ?fatty? fa/fa rat [PDF]

, 1981
David A. York, Narinder S. Shargill, V. Godbole   +2 more
openalex   +1 more source

Dietary Consumption of Type 2 Resistant Starch and d‐Fagomine Delays Progression of Metabolic Disturbances in Male Rats on High‐Fat Diet

Molecular Nutrition &Food Research, EarlyView.
This study compared the preventive effects of dietary resistant starch (RS2) from maize and d‐fagomine (FG) from buckwheat on cardiometabolic risk factors in high‐fat (HF) diet‐fed rats. Wistar‐Kyoto rats (n = 11–12/group) received STD, HF, HF + RS, or HF + FG diets for 10 weeks.
Bernat Miralles‐Pérez, Sara Ramos‐Romero, María José Charpentier, Vanessa Sánchez‐Martos, Àngels Fortuño‐Mar, Julia Ponomarenko, Susana Amézqueta, David Piñol‐Piñol, Xiang Zhang, Josep Lluís Torres, Marta Romeu   +10 more
wiley   +1 more source