Enterococcal periprosthetic joint infection: clinical and microbiological findings from an 8-year retrospective cohort study [PDF]
, 2019 BACKGROUND: Treatment of enterococcal periprosthetic joint infections (PJI) is challenging due to non-standardized management strategies and lack of biofilm-active antibiotics. The optimal surgical and antimicrobial therapy are unknown.
Akgün, Doruk +4 more
core +1 more source
Oritavancin vs Standard of Care for Treatment of Nonendovascular Gram-Positive Bloodstream Infections [PDF]
, 2023 BACKGROUND: Data is limited comparing oritavancin (ORT) to the standard-of-care (SOC) for the treatment gram-positive blood stream infections (BSI). METHODS: This was a retrospective study of all patients in the Veteran\u27s Affairs Health Care System ...
Abdulbasir, Anosha +12 more
core +2 more sources
Structure–activity relationships of antibacterial peptides
Microbial Biotechnology, Volume 16, Issue 4, Page 757-777, April 2023., 2023 Antimicrobial peptides play a crucial role in innate immunity, whose components are mainly peptide‐based molecules with antibacterial properties.This review provides a discussion regarding the antibacterial mechanisms of peptide‐based agents and their structure‐activity relationships (SARs) with the aim of describing a topic that is not yet fully ...
Maria Gessica Ciulla, Fabrizio Gelain
wiley +1 more source
Treatment of Enterococcus faecalis Infective Endocarditis: A Continuing Challenge
Antibiotics, 2023 Today, Enterococcus faecalis is one of the main causes of infective endocarditis in the world, generally affecting an elderly and fragile population, with a high mortality rate.
Laura Herrera-Hidalgo +5 more
doaj +1 more source
Beyond conventional antibiotics for the future treatment of methicillin-resistant Staphylococcus aureus infections: two novel alternatives. [PDF]
, 2012 The majority of antibiotics currently used to treat methicillin-resistant Staphylococus aureus (MRSA) infections target bacterial cell wall synthesis or protein synthesis. Only daptomycin has a novel mode of action.
Devocelle, Marc +2 more
core +1 more source
Design of Antimicrobial Polymers
Macromolecular Chemistry and Physics, Volume 224, Issue 3, February 2023., 2023 Antibiotic resistance has become a critical issue worldwide. Thanks to rapid advancements in polymer science, antimicrobial polymers have been developed as a mimic version of host‐defense peptides (a part of natural immune systems of multicellular organisms) to mitigate antibiotic resistance.
Phuong Pham, Susan Oliver, Cyrille Boyer
wiley +1 more source
Assessment of Minimum Inhibitory Concentrations of Telavancin by Revised Broth Microdilution Method in Phase 3 Hospital-Acquired Pneumonia/Ventilator-Associated Pneumonia Clinical Isolates [PDF]
, 2016 INTRODUCTION: The broth microdilution method (BMD) for testing telavancin minimum inhibitory concentrations (MICs) was revised (rBMD) in 2014 to improve the accuracy, precision, and reproducibility of the testing method.
Gordon Ralph Corey +4 more
core +1 more source
Clinical and Translational Science, Volume 15, Issue 12, Page 2796-2811, December 2022., 2022 Abstract Several human host proteins play important roles in the lifecycle of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Many drugs targeting these host proteins have been investigated as potential therapeutics for coronavirus disease 2019 (COVID‐19).
Jiapeng Li +6 more
wiley +1 more source
The Continuing Threat of Methicillin-Resistant Staphylococcus aureus
Antibiotics, 2019 Staphylococcus aureus has been an exceptionally successful pathogen, which is still relevant in modern age-medicine due to its adaptability and tenacity.
Márió Gajdács
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 Methicillin-resistant S. aureus (MRSA) are resistant to beta-lactams, but synergistic activity between beta-lactams and glycopeptides/lipopeptides is common.
Rutan Zhang +9 more
doaj +1 more source