Results 31 to 40 of about 46,973 (295)

Characterization and epitope mapping of human monoclonal antibodies to PDC-E2, the immunodominant autoantigen of primary biliary cirrhosis [PDF]

, 1992
Further to define the epitopes of PDC-E2, the major autoantigen in primary biliary cirrhosis (PBC), we have developed and characterized five human monoclonal antibodies. These antibodies were derived by fusing a regional hepatic lymph node from a patient
Bassendine, Baum, Casali, Chambers, Coppel, Coppel, Cram, Flannery, Fregeau, Fregeau, Fujikura, Fusey, Fussey, Gershwin, Gershwin, Griffin, Griffin, James, Kaplan, Kunicki, Larrick, Leung, Leung, Mackay, Mackay, Mathews, McNeilage, Okamoto, Pollack, Ramsden, Reeves, Reimer, Robbins, Rokeach, Rowley, Ruther, Salemuddin, Sturgess, Sudin, Surh, Surh, Surh, Surh, Tan, Uibo, Van de Water, Van de Water, Van de Water, Van de Water, Williams   +49 more
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From discovery to scale-up: alpha-lipoic acid : nicotinamide co-crystals in a continuous oscillatory baffled crystalliser [PDF]

, 2014
The crystalline nutritional supplement alpha-lipoic acid degrades rapidly on exposure to temperatures above its melting point 65 degrees C and to light.
Bhardwaj, Rajni M., Briggs, Naomi E. B., Florence, Alastair J., McGlone, Thomas, Oswald, Iain D. H., Raval, Vishal, Zhao, Lihua   +6 more
core   +1 more source

Gut microbiota markers in obese adolescent and adult patients: Age-dependent differential patterns [PDF]

, 2018
Obesity levels, especially in children, have dramatically increased over the last few decades. Recently, several studies highlighted the involvement of gut microbiota in the pathophysiology of obesity. We investigated the composition of gut microbiota in
Alessandra Russo, Andrea Quagliariello, Bruno Dallapiccola, Danila Capoccia, Federica Del Chierico, Francesca Abbatini, Francesco De Peppo, Frida Leonetti, Gianfranco Silecchia, Lorenza Putignani, Lorenza Putignani, Romina Caccamo, Sofia Reddel, Stefano Ginanni Corradini, Valerio Nobili, Valerio Nobili   +15 more
core   +2 more sources

A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization [PDF]

, 2007
Background Endothelial dysfunction (ED) is functionally characterized by decreased vasorelaxation, increased thrombosis, increased inflammation, and altered angiogenic potential, has been intimately associated with the progression and severity of ...
Ceriello, Antonio, Green, Dixy E., Ihnat, Michael A., Kamat, Chandrashekhar D., Shenoy, Satyendra S, Thorpe, Jessica E, Warnke, Linda A.   +6 more
core   +3 more sources

Neuroprotective Effects of Alpha Lipoic Acid on Haloperidol-Induced Oxidative Stress in the Rat Brain

Cell & Bioscience, 2011
Haloperidol is an antipsychotic drug that exerts its' antipsychotic effects by inhibiting dopaminergic neurons. Although the exact pathophysiology of haloperidol extrapyramidal symptoms are not known, the role of reactive oxygen species in inducing ...
Perera Joachim, Tan Joon, Jeevathayaparan S, Chakravarthi Srikumar, Haleagrahara Nagaraja   +4 more
doaj   +1 more source

Nonlinear optical properties of Au-nanoparticles conjugated with lipoic acid in water [PDF]

Journal of the European Optical Society-Rapid Publications, 2014
Gold nanoparticles were chemically conjugated with lipoic acid to control their optical properties. Z-scan and other optical techniques were used to characterize the non-linear behavior of the resulting nanostructured materials. The results show that the
Trejo-Durán M., Cornejo-Monroy D., Alvarado-Méndez E., Olivares-Vargas A., Castaño V. M.   +4 more
doaj   +1 more source

Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. [PDF]

, 2008
The development of type 2 diabetes is accompanied by decreased immune function and the mechanisms are unclear. We hypothesize that oxidative damage and mitochondrial dysfunction may play an important role in the immune dysfunction in diabetes.
Hao, Jiejie, Liu, Jiankang, Liu, Zhongbo, Long, Jiangang, Luo, Cheng, Ren, Jinmin, Sharman, Edward, Shen, Weili, Tian, Chuan   +8 more
core   +1 more source

Safety and Efficacy of Alpha Lipoic Acid During 4 Years of Observation: A Retrospective, Clinical Trial in Healthy Subjects in Primary Prevention

Drug Design, Development and Therapy, 2020
Giuseppe Derosa,1,2 Angela D’Angelo,2 Paola Preti,1 Pamela Maffioli1 1Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; 2Laboratory of Molecular Medicine, University of Pavia, Pavia, ItalyCorrespondence: Giuseppe ...
Derosa G, D'Angelo A, Preti P, Maffioli P   +3 more
doaj  

Cerium(IV) and Iron(III) Oxides Nanoparticles Based Voltammetric Sensor for the Sensitive and Selective Determination of Lipoic Acid

Sensors, 2021
A novel voltammetric sensor based on CeO2·Fe2O3 nanoparticles (NPs) has been developed for the determination of lipoic acid, playing an essential role in aerobic metabolism in the living organism.
Guzel Ziyatdinova, Liliya Gimadutdinova
doaj   +1 more source

Impact of Dietary α-Lipoic Acid on Antioxidant Potential of Broiler Thigh Meat

Journal of Chemistry, 2015
The lipid oxidation depressed the meat quality and can be triggered during industrial processing. The current study was designed to assess the antioxidant activity of thigh meat and meat products enriched with natural antioxidants (α-lipoic acid and α ...
Muhammad Issa Khan, Komal Shehzad, Muhammad Sajid Arshad, Amna Sahar, Muhammad Asim Shabbir, Muhammad Saeed   +5 more
doaj   +1 more source