Results 11 to 20 of about 40,812 (258)

Diabetes and alpha lipoic acid [PDF]

Frontiers in Pharmacology, 2011
Diabetes mellitus is a multi-faceted metabolic disorder where there is increased oxidative stress that contributes to the pathogenesis of this debilitating disease.
Issy eLaher
doaj   +3 more sources

Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid

Nature Communications, 2023
Lipoic acid is an essential enzyme cofactor in central metabolic pathways. Due to its claimed antioxidant properties, racemic (R/S)-lipoic acid is used as a food supplement but is also investigated as a pharmaceutical in over 180 clinical trials covering
Severin Lechner, Raphael R. Steimbach, Longlong Wang, Marshall L. Deline, Yun-Chien Chang, Tobias Fromme, Martin Klingenspor, Patrick Matthias, Aubry K. Miller, Guillaume Médard, Bernhard Kuster   +10 more
doaj   +1 more source

Palladium (II) chloride (PdCl2) spectrophotometry to determine lipoic acid concentration in plasma and leukocytes

Acta Biochimica Indonesiana, 2020
Background: Lipoic acid is a substance contained in intra and extracellular that act as a coenzyme of Pyruvate Dehydrogenase, also as an antidote, chelating agent and antioxidant.
Novian Agni Yudhaswara, Ani Retno Prijanti, Mohamad Sadikin   +2 more
doaj   +1 more source

DETERMINATION OF CENTRAL NERVOUS EFFECT AND ANTIDOTAL EFFECT AGAINST CHLORPYRIFOS TOXICITY OF ALPHA-LIPOIC ACID THROUGH PHARMACOLOGICAL AND TOXICOLOGICAL CHALLENGES

SVU-International Journal of Veterinary Sciences, 2022
Background: Pharmacological and toxicological challenges are among the most important studies in revealing the latent properties of drugs Objective: the goal of this study was to evaluate the effects of alpha-lipoic acid on the central nervous system ...
Marwa Abdul-Ghani, Ahmed Naser
doaj   +1 more source

A comparison of melatonin and α-lipoic acid in the induction of antioxidant defences in L6 rat skeletal muscle cells. [PDF]

, 2015
Aging is characterized by a progressive deterioration in physiological functions and metabolic processes. The loss of cells during aging in vital tissues and organs is related to several factors including oxidative stress and inflammation.
Borsani, Elisa, Cocchi, Marco Angelo, Favero, Gaia, Giugno, Lorena, Nardo, Lorenzo, Reiter, Russel J, Rezzani, Rita, Rodella, Luigi Fabrizio   +7 more
core   +1 more source

Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. [PDF]

, 2008
The development of type 2 diabetes is accompanied by decreased immune function and the mechanisms are unclear. We hypothesize that oxidative damage and mitochondrial dysfunction may play an important role in the immune dysfunction in diabetes.
Hao, Jiejie, Liu, Jiankang, Liu, Zhongbo, Long, Jiangang, Luo, Cheng, Ren, Jinmin, Sharman, Edward, Shen, Weili, Tian, Chuan   +8 more
core   +1 more source

BACE1 activity impairs neuronal glucose oxidation:rescue by beta-hydroxybutyrate and lipoic acid [PDF]

, 2015
Glucose hypometabolism and impaired mitochondrial function in neurons have been suggested to play early and perhaps causative roles in Alzheimer's disease (AD) pathogenesis. Activity of the aspartic acid protease, beta-site amyloid precursor protein (APP)
Arsenian, Bateman, Beal, Bielarczyk, Blass, Bogaert, Bosetti, Bouzier-Sore, Bubber, Butterworth, Casley, Casley, Caspersen, Coleman, Costantini, Danial, David L. Hamilton, DeKosky, DeKosky, Devi, Du, Fang, Forero, Fukumoto, Geula, Gibson, Giménez-Cassina, Guglielmotto, Gómez-Isla, Hager, Hamilton, Harada, Henderson, Henderson, Hirai, Holsinger, Huang, Hussain, Itoh, Jack, Jack, Jack, Jha, John A. Findlay, Johnson, Kankotia, Kawaja, Kim, Knopman, Ko, Korolainen, Lei, Li, Lustbader, Magistretti, Manczak, Martiskainen, Masdeu, Mastrogiacoma, Maurer, McKenna, Meakin, Michael L. J. Ashford, Mirshamsi, Mosconi, Mosconi, Mowrer, Mucke, Mullen, Nelson, Nilsen, Nunomura, O'Connor, Packer, Parker, Patel, Pereira, Perry, Phypers, Puglielli, Reger, Reiman, Sancheti, Shankar, Shearman, Sinha, Small, Sokoloff, Sorbi, Sowell, Swerdlow, Tyler, Vaishnavi, Vassar, Vassar, Velliquette, Vlassenko, von Kienlin, Wilkins, Wischmeyer, Wise, Xun, Yang, Yao, Yao, Zaidan, Zhang, Zhang, Zhao   +108 more
core   +6 more sources

Staphylococcus aureus Tissue Infection During Sepsis Is Supported by Differential Use of Bacterial or Host-Derived Lipoic Acid.

PLoS Pathogens, 2016
To thrive in diverse environments, bacteria must shift their metabolic output in response to nutrient bioavailability. In many bacterial species, such changes in metabolic flux depend upon lipoic acid, a cofactor required for the activity of enzyme ...
Azul Zorzoli, James P Grayczyk, Francis Alonzo   +2 more
doaj   +1 more source

The Effect of Alpha-Lipoic Acid against Methotrexate on Testicular Damage in Rats

Journal of Contemporary Medicine, 2023
Aim: The toxic effects of methotrexate, a chemotherapeutic, on the testicles is an important side effect. Methotrexate impairs spermatogenesis and fertility and causes oligospermia. In this study, we aimed to minimize the testicular toxicity, those being
Ahmetcan Varel, Meltem Özgöçmen, Hamit Hakan Armağan, İbrahim Aydın Candan, Dilek Bayram, İlkay Armağan   +5 more
doaj   +1 more source

Studies on the sulfation of cellulose α-lipoate and ability of the sulfated product to stabilize colloidal suspensions of gold nanoparticles [PDF]

, 2015
© 2015 Elsevier Ltd. A versatile method for the synthesis of cellulose α-lipoate with a low degree of substitution (DS) has been developed using N,N-dimethylacetamide (DMA)/LiCl as a solvent and N,N′-carbonyldiimidazole (CDI) as an esterification reagent.
Cheng, Fei, Heinze, Thomas, Kelly, Stephen M., Koschella, Andreas, Sarbova, Velina   +4 more
core   +2 more sources