Results 11 to 20 of about 2,527,105 (193)

Biosynthesis of Lipoic Acid in Arabidopsis: Cloning and Characterization of the cDNA for Lipoic Acid Synthase [PDF]

Plant Physiology, 1998
Abstract Lipoic acid is a coenzyme that is essential for the activity of enzyme complexes such as those of pyruvate dehydrogenase and glycine decarboxylase. We report here the isolation and characterization of LIP1 cDNA for lipoic acid synthase of Arabidopsis.
R, Yasuno, H, Wada
openaire   +3 more sources

THE COMBINATION OF α-LIPOIC ACID INTAKE WITH ECCENTRIC EXERCISE MODULATES ERYTHROPOIETIN RELEASE

Biology of Sport, 2014
The generation of reactive nitrogen/oxygen species (RN/OS) represents an important mechanism in erythropoietin (EPO) expression and skeletal muscle adaptation to physical and metabolic stress.
B. Morawin, D. Turowski, M. Naczk, I. Siatkowski, A. Zembron-Lacny   +4 more
doaj   +2 more sources

Encapsulation of α-lipoic acid intochitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activity [PDF]

Hemijska Industrija, 2016
Alpha-lipoic acidis an organosulphur compound well-known for its therapeutic potential and antioxidant properties. However, the effective use of α-lipoic acid depends on biological plasma half-life and its preserving stability, which could be ...
Vidović Bojana B., Milašinović Nikola Z., Kotur-Stevuljević Jelena M., Dilber Sanda P., Kalagasidis-Krušić Melina T., Đorđević Brižita I., Knežević-Jugović Zorica D.   +6 more
doaj   +1 more source

Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid

Nature Communications, 2023
Lipoic acid is an essential enzyme cofactor in central metabolic pathways. Due to its claimed antioxidant properties, racemic (R/S)-lipoic acid is used as a food supplement but is also investigated as a pharmaceutical in over 180 clinical trials covering
Severin Lechner, Raphael R. Steimbach, Longlong Wang, Marshall L. Deline, Yun-Chien Chang, Tobias Fromme, Martin Klingenspor, Patrick Matthias, Aubry K. Miller, Guillaume Médard, Bernhard Kuster   +10 more
doaj   +1 more source

Palladium (II) chloride (PdCl2) spectrophotometry to determine lipoic acid concentration in plasma and leukocytes

Acta Biochimica Indonesiana, 2020
Background: Lipoic acid is a substance contained in intra and extracellular that act as a coenzyme of Pyruvate Dehydrogenase, also as an antidote, chelating agent and antioxidant.
Novian Agni Yudhaswara, Ani Retno Prijanti, Mohamad Sadikin   +2 more
doaj   +1 more source

Alpha-Lipoic Acid Protects Co-Exposure to Lead and Zinc Oxide Nanoparticles Induced Neuro, Immuno and Male Reproductive Toxicity in Rats

Frontiers in Pharmacology, 2021
We evaluated the neuro-, immuno-, and male reproductive toxicity of zinc oxide nanoparticles (ZnO NPs) alone and in combination with lead acetate. We also studied the therapeutic role of α-lipoic acid postexposure.
Monika S. Deore, Keerthana S, Saba Naqvi, Anoop Kumar, S. J. S. Flora   +4 more
doaj   +1 more source

Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum [PDF]

, 2007
Lipoic acid (LA) is an essential cofactor of α-keto acid dehydrogenase complexes (KADHs) and the glycine cleavage system. In Plasmodium, LA is attached to the KADHs by organelle-specific lipoylation pathways.
Ryan Bissett, Carsten Wrenger, Gunther, M, Storm Janet, McMillan, Paul, Günther, S, Müller, S, Wallace, L., Muller, S., Patzewitz, Eva-Maria, Paul J McMillan, Lynsey Wallace, Wrenger, C., Günther, S., Bissett Ryan, Wrenger, Carsten, Smith, T.K., Muller, Sylke, McMillan Paul J, Bissett, Ryan, Guenther, Svenja, McMillan, Paul J., Smith, Terry, Sylke Müller, Patzewitz, E.-M., Terry K Smith, Storm, J., Günther Svenja, Storm, Janet, Svenja Günther, Patzewitz, EM, Wallace, Lynsey, Storm, J, McMillan, PJ, Patzewitz Eva-Maria, Mueller, Sylke, McMillan, P.J., Eva-Maria Patzewitz, Wallace Lynsey, Bissett, R, Wrenger, C, Janet Storm, Smith Terry K, Smith, TK, Wrenger Carsten, Smith, Terry K, Wallace, L, Bissett, R., Müller Sylke   +48 more
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DETERMINATION OF CENTRAL NERVOUS EFFECT AND ANTIDOTAL EFFECT AGAINST CHLORPYRIFOS TOXICITY OF ALPHA-LIPOIC ACID THROUGH PHARMACOLOGICAL AND TOXICOLOGICAL CHALLENGES

SVU-International Journal of Veterinary Sciences, 2022
Background: Pharmacological and toxicological challenges are among the most important studies in revealing the latent properties of drugs Objective: the goal of this study was to evaluate the effects of alpha-lipoic acid on the central nervous system ...
Marwa Abdul-Ghani, Ahmed Naser
doaj   +1 more source

Alpha-Lipoic Acid for the Prevention of Diabetic Macular Edema [PDF]

, 2011
Introduction: To evaluate the effect of alpha-lipoic acid (ALA) on the occurrence of diabetic macular edema. Methods: Randomized, double-blind, placebo-controlled, multicenter, multinational study. Patients were randomized to the treatment group with 600
Haritoglou, Christos, Anselm Kampik, Joachim Gerss, Gerss, Joachim, Hammes, Hans P., Ulbig, Michael W., null null, Christos Haritoglou, Kampik, Anselm, Hans P. Hammes, Michael W. Ulbig   +10 more
core   +1 more source

Knockout studies reveal an important role of plasmodium lipoic acid protein ligase a1 for asexual blood stage parasite survival [PDF]

, 2009
Lipoic acid (LA) is a dithiol-containing cofactor that is essential for the function of a-keto acid dehydrogenase complexes. LA acts as a reversible acyl group acceptor and 'swinging arm' during acyl-coenzyme A formation.
Sylke Müller, Kai Matuschewski, Günther, S., Matsuscheski, K., Gunther, M, Günther Svenja, Matuschewski, K., Matuschewski Kai, Matuschewski, Kai, Svenja Günther, Muller, S., Müller Sylke, Muller, Sylke   +12 more
core   +2 more sources