Results 91 to 100 of about 26,449 (239)
Structure of the lipopeptide antibiotic tsushimycin
Acta Crystallographica Section D Biological Crystallography, 2005 The amphomycin derivative tsushimycin has been crystallized and its structure determined at 1.0 A resolution. The asymmetric unit contains 12 molecules and with 1300 independent atoms this structure is one of the largest solved using ab initio direct methods.
Bunkoczi, G. +2 more
openaire +3 more sources
Environmental Toxicology, EarlyView.ABSTRACT Mold growth in damp indoor environments is a widespread problem associated with respiratory health effects, though causal mechanisms remain incompletely understood. We established a human cell‐based in vitro test system using bronchial epithelial cells (NuLi‐1) and macrophages (THP‐1) to assess inhalation toxicity and immunomodulatory effects ...
Anja Wolff +8 more
wiley +1 more source
Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity
VIEW, EarlyView.Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin +3 more
wiley +1 more source
BiomoleculesBanana crop ranks among the most crucial fruit and food crops in tropical and subtropical areas. Despite advancements in production technology, diseases such as cordana leaf spot, caused by Neocordana musae, remain a significant challenge, reducing ...
Qunfang Yu +9 more
doaj +1 more source
The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1
The FEBS Journal, EarlyView.ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu +2 more
wiley +1 more source
Frontiers in Immunology, 2013 Peptide based vaccines offer several advantages over conventional whole organism or protein approaches by offering improved purity and specificity in inducing immune response. However, peptides alone are generally non-immunogenic.
Mehfuz eZaman +2 more
doaj +1 more source
Deciphering Role of Endophytes in Plant Defences and Biotic Stress Resilience Across Families
Plant, Cell &Environment, EarlyView.ABSTRACT Plant families generate distinct repertoires of specialised metabolites that govern their biotic interactions. Endophytes strengthen host plant defence mechanisms and tolerance to biotic challenges by upregulating metabolite biosynthesis, modifying precursor compounds into more potent forms, or by directly synthesising analogous defence ...
S. Aneeqa Noor +4 more
wiley +1 more source
Recent Advances in Toll Like Receptor-Targeting Glycoconjugate Vaccines
Molecules, 2018 Many malignant cell surface carbohydrates resulting from abnormal glycosylation patterns of certain diseases can serve as antigens for the development of vaccines against these diseases.
Qingjiang Li, Zhongwu Guo
doaj +1 more source
Plant, Cell &Environment, EarlyView.ABSTRACT Plant‐fungus‐virus tripartite interactions represent complex ecological systems in which mutualistic endophytes can influence host physiology, yet the molecular basis of endophyte‐mediated defence remains poorly understood. Here, we demonstrate that the endophytic fungus Penicillium pinophilum EU0013 suppresses the yellow strain of cucumber ...
Sarah R. Ibiang +3 more
wiley +1 more source
Genetic and functional characterization of the gene cluster directing the biosynthesis of putisolvin I and II in Pseudomonas putida strain PCL1445 [PDF]
, 2008 Pseudomonas putida PCL1445 secretes two cyclic lipopeptides, putisolvin I and putisolvin II, which possess a surface-tension-reducing ability, and are able to inhibit biofilm formation and to break down biofilms of Pseudomonas species including ...
Dubern, J.F. +3 more
core +1 more source