Results 181 to 190 of about 29,837 (216)

Synthetic lipopeptides as novel adjuvants

Research in Immunology, 1992
Lipopeptides constitute potent novel immunoadjuvants in mice, rabbits and other species, enhancing markedly the immune response when given in mixture with antigens. Lipopeptides are non-toxic, non-pyrogenic and do not induce tissue damage when injected.
W G, Bessler, G, Jung
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Synthesis of MUC1–lipopeptide chimeras

Chemical Communications, 2010
An efficient method for the convergent assembly of MUC1-lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the T(N) and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam(3)CysSer were synthesised in high yields using a fragment-based condensation ...
Brendan L, Wilkinson, Lara R, Malins, Candy K Y, Chun, Richard J, Payne   +3 more
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Cyclopeptamine lipopeptide antifungal agents

Expert Opinion on Therapeutic Patents, 1999
A solid phase mediated automated process was developed and used by researchers at Abbott laboratories to synthesise structurally diverse amino-lipopeptides as antifungal compounds. The cyclopeptamine analogues produced by this method possess an amino or substituted amino functionality in the proline ring (A) (Figure 2).
Debashis Ganguly, Michael J Rodriguez
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Synthesis of Lipopeptides by CLipPA Chemistry

2021
Lipidation of polypeptides with a fatty acid to form N-linked lipopeptides can be a time consuming process due to the need to mask other reactive function groups present on the side chains of amino acids. Cysteine Lipidation on a Peptide or Amino acid (CLipPA) technology enables the direct lipidation of unprotected peptides containing a free thiol ...
Victor, Yim, Yann O, Hermant, Paul W R, Harris, Margaret A, Brimble   +3 more
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Structure elucidation of bacterial nonribosomal lipopeptides

Organic & Biomolecular Chemistry, 2020
We provide a summary of the tools, which allow elucidate the structures of nonribosomal lipopetides.
Sebastian Götze, Pierre Stallforth
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Structure–Activity Relationships of Daptomycin Lipopeptides

Journal of Medicinal Chemistry, 2020
Daptomycin is a calcium-dependent cyclic lipodepsipeptide derived from the soil saprotroph Streptomyces roseosporus, and its antibiotic properties make it a key agent for treatment of drug-resistant Gram-positive infections. It is most commonly used clinically for the treatment of Gram-positive skin and skin structure infections (SSSI), Staphylococcus ...
John A. Karas, Glen P. Carter, Benjamin P. Howden, Adrianna M. Turner, Olivia K. A. Paulin, James D. Swarbrick, Mark. A. Baker, Jian Li, Tony Velkov   +8 more
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Discovery of the Cyclic Lipopeptide Gacamide A by Genome Mining and Repair of the Defective GacA Regulator in Pseudomonas fluorescens Pf0-1.

Journal of Natural Products, 2019
Genome mining of the Gram-negative bacterium Pseudomonas fluorescens Pf0-1 showed that the strain possesses a silent NRPS-based biosynthetic gene cluster encoding a new lipopeptide; its activation required the repair of the global regulator system.
Gahzaleh Jahanshah, Qing Yan, Heike Gerhardt, Zoltán Pataj, M. Lämmerhofer, I. Pianet, Michaele Josten, H. Sahl, M. Silby, J. Loper, H. Gross   +10 more
semanticscholar   +1 more source

Fungi‐derived lipopeptide antibiotics developed since 2000

Peptides, 2019
&NA; Lipopeptide antibiotics have linear or cyclic structures with one or more hydrocarbon tails linked to the N‐terminus of a short oligopeptide that may be chemically modified and/or contain unusual amino acid residues in their structures. They possess
Pengchao Zhao, Y. Xue, Xin Li, Jinghua Li, Zhanqin Zhao, C. Quan, Weina Gao, Xiangyang Zu, Xuefei Bai, Shuxiao Feng   +9 more
semanticscholar   +1 more source

Novel dendrimeric lipopeptides with antifungal activity

Bioorganic & Medicinal Chemistry Letters, 2012
A series of new cationic lipopeptides containing branched, amphiphilic polar head derived from (Lys)Lys(Lys) dendron and C(8) or C(12) chain at C-end were designed, synthesized and characterized. Antimicrobial in vitro activity expressed as minimal inhibitory concentration (MIC) was evaluated against Gram-positive and Gram-negative bacteria and yeasts ...
Jolanta, Janiszewska, Marta, Sowińska, Aleksandra, Rajnisz, Jolanta, Solecka, Izabela, Łącka, Sławomir, Milewski, Zofia, Urbańczyk-Lipkowska   +6 more
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Lipopeptide Biosurfactants From Bacillus Species

Biobased Surfactants, 2019
The following chapter will give an overview on different Bacillus lipopeptides and their respective biosynthesis. Furthermore, the regulation of surfactin synthesis, which is regulated via a complex quorum-sensing system, will be covered, as well as the ...
Mareen Geissler, K. M. Heravi, Marius Henkel, R. Hausmann   +3 more
semanticscholar   +1 more source