Results 41 to 50 of about 29,837 (216)

A Palmitic Acid-Conjugated, Peptide-Based pan-CoV Fusion Inhibitor Potently Inhibits Infection of SARS-CoV-2 Omicron and Other Variants of Concern

open access: yesViruses, 2022
Our previous studies have shown that cholesterol-conjugated, peptide-based pan-coronavirus (CoV) fusion inhibitors can potently inhibit human CoV infection. However, only palmitic acid (C16)-based lipopeptide drugs have been tested clinically, suggesting
Qiaoshuai Lan   +12 more
doaj   +1 more source

Optimization of Surfactin Production by Bacillus amyloliquefaciens MD4-12 using Response Surface Methodology

open access: yesMicrobiology Indonesia, 2015
Surfactin is a lipopeptide biosurfactant that show potential biomedical application due to its activities such as antiviral, antibacterial, antifungi, anticancer, and antimycoplasma. Bacillus amyloliquefaciens MD4-12, isolated from oil-contaminated soil,
AHMAD WIBISANA   +3 more
doaj   +1 more source

Structure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants

open access: yesEmerging Microbes and Infections, 2021
The ongoing pandemic of COVID-19, caused by SARS-CoV-2, has severely impacted the global public health and socio-economic stability, calling for effective vaccines and therapeutics.
Danwei Yu   +11 more
doaj   +1 more source

The interplay between daptomycin and the immune system

open access: yesFrontiers in Immunology, 2014
Antibiotics may have bacteriostatic or bactericidal effects but may also cause immunomodulation. Lipopeptides are known immunomodulators that interact with pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) in antigen presenting ...
Theodoros eKelesidis
doaj   +1 more source

Iturinic Lipopeptide Diversity in the Bacillus subtilis Species Group – Important Antifungals for Plant Disease Biocontrol Applications

open access: yesFrontiers in Microbiology, 2019
Iturins and closely related lipopeptides constitute a family of antifungal compounds known as iturinic lipopeptides that are produced by species in the Bacillus subtilis group.
C. Dunlap, M. J. Bowman, A. Rooney
semanticscholar   +1 more source

Effects of Bacillus amyloliquefaciens XJ-BV2007 on Growth of Alternaria alternata and Production of Tenuazonic Acid

open access: yesToxins, 2023
Large amounts of processing tomato are grown in Xinjiang, China. Tomato black spot disease, caused by Alternaria spp., and the produced alternaria toxins in tomato products are posing risks to human health.
Qinlan Jia   +8 more
doaj   +1 more source

Production of Lipopeptide Biosurfactant by a Hydrocarbon-Degrading Antarctic Rhodococcus

open access: yesInternational Journal of Molecular Sciences, 2020
Rhodococci are renowned for their great metabolic repertoire partly because of their numerous putative pathways for large number of specialized metabolites such as biosurfactant.
Syahir Habib   +8 more
semanticscholar   +1 more source

Safety, tolerability, and biomarkers of the treatment of mice with aerosolized toll-like receptor ligands

open access: yesFrontiers in Pharmacology, 2014
We have previously discovered a synergistically therapeutic combination of two Toll-like receptor (TLR) ligands, an oligodeoxynucleotide (ODN) and Pam2CSK4.
Victoria eAlfaro   +11 more
doaj   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

open access: yesAdvanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang   +4 more
wiley   +1 more source

Brevibacillin 2V, a Novel Antimicrobial Lipopeptide With an Exceptionally Low Hemolytic Activity

open access: yesFrontiers in Microbiology, 2021
Bacterial non-ribosomally produced peptides (NRPs) form a rich source of antibiotics, including more than 20 of these antibiotics that are used in the clinic, such as penicillin G, colistin, vancomycin, and chloramphenicol.
Xinghong Zhao   +7 more
doaj   +1 more source

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