Results 101 to 110 of about 27,539 (254)
MedComm, Volume 6, Issue 10, October 2025.Respiratory syncytial virus (RSV) causes substantial global morbidity, particularly in infants and elderly populations. This review summarizes key viral pathogenesis mechanisms and highlights recent advances in both prophylactic (vaccines, antibodies) and therapeutic (antiviral agents) strategies against RSV.
Xiaowen Liang +7 more
wiley +1 more source
Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]
, 2011 Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
core +1 more source
Lipopeptides as anti-infectives: a practical perspective
Open Life Sciences, 2009 AbstractLipopeptide antibiotics represent an old class of antibiotics that were discovered over 50 years ago, which includes the old polymyxins but also new entries, such as the recently approved daptomycin. They generally consist of a hydrophilic cyclic peptide portion attached to a fatty acid chain which facilitates insertion into the lipid bilayer ...
PIRRI G +4 more
openaire +5 more sources
Hijacking the Electron Train: Menaquinone‐Binding Antimicrobial Peptides
ChemBioChem, Volume 26, Issue 18, September 18, 2025.Menaquinone is an emerging target for antimicrobial peptides. Could it be the new Achilles’ Heel of bacteria? The rise of antibiotic resistance threatens to undermine modern medicine, making the development of new antibiotics and novel targets an urgent priority.
Eilidh J. Matheson, Stephen A. Cochrane
wiley +1 more source
Role of Toll-like receptors in development of postpartum endometritis [PDF]
, 2011 The aim of the study was to establish the association between expression of TLR1 (ligands - triacyl lipopeptides), TLR2 (ligands - lipopeptides, lipoteichoic acid, zymosan), and TLR 5 (ligand - flagellin) of cervical epithelial cells in vivo and ...
Lebedeva, O. +2 more
core
Biosynthesis, chemical structure, and structure-activity relationship of orfamide lipopeptides produced by Pseudomonas protegens and related species [PDF]
, 2016 Orfamide type cyclic lipopeptides (CLPs) are biosurfactants produced by Pseudomonas and involved in lysis of oomycete zoospores, biocontrol of Rhizoctonia and insecticidal activity against aphids.
Geudens, Niels +6 more
core +3 more sources
ChemBioChem, Volume 26, Issue 16, September 12, 2025.SLIPT‐PM enables the translocation of tag‐fused proteins from the cytoplasm to the plasma membrane using a synthetic self‐localizing ligand. This user‐friendly system permits reversible control of diverse signaling pathways. This concept article highlights the key features and current applications of SLIPT‐PM as a powerful tool in chemical and ...
Shuya Ohira +3 more
wiley +1 more source
Adjuvant lipopeptide interaction with model membranes
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1998 The cationic lipohexapeptide Pam3Cys-Ser-(Lys)4 is a synthetic model for the triacylated N-terminal part of bacterial lipoproteins, and it is used as an adjuvant and macrophage activator. The amphiphilic lipopeptide was injected below a phosphatidylserine monolayer at the air-water interface.
Gilbert Lanéelle +6 more
openaire +3 more sources
Advanced Healthcare Materials, Volume 14, Issue 23, September 8, 2025.This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail +3 more
wiley +1 more source
Molecular mechanisms of autoimmunity triggered by microbial infection [PDF]
, 2005 Autoimmunity can be triggered by microbial infection. In this context, the discovery of Toll-like receptors (TLRs) provides new insights and research perspectives.
Anders, Hans-Joachim +3 more
core +2 more sources