Results 81 to 90 of about 23,990 (259)

Diversity of FAAL enzymes and prediction of their substrate specificity using FAALPred

Protein Science, Volume 35, Issue 2, February 2026.
Abstract FAALs (fatty acyl‐AMP ligases) recruit and incorporate fatty acids during the biosynthesis of secondary metabolites. Their diversity, distribution, and substrate specificity remain poorly understood, which limits functional predictions from sequence data.
Anne Liong, Leandro de Mattos Pereira, Pedro N. Leão   +2 more
wiley   +1 more source

Antioxidant properties of Enterobacter cloacae C3 lipopeptides in vitro and in model food emulsion

Journal of food processing and preservation, 2020
The present work aims to investigate the in vitro antioxidant activities of Enterobacter cloacae C3 lipopeptides, as well as the stability of sunflower oil in water (o/w) emulsion and the conservation of raw beef patties. The C3 lipopeptides were assayed
Noomen Hmidet, Nawel Jemil, Manel Ouerfelli, María Pilar Almajano, M. Nasri   +4 more
semanticscholar   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

In Vitro Evaluation of Cytotoxicity and Permeation Study on Lysine- and Arginine-Based Lipopeptides with Proven Antimicrobial Activity

Molecules, 2017
Owing to their excellent antimicrobial activities with a relatively low cost of production, lipopeptides are being intensively investigated as potential alternatives to popular antimicrobials.
Malgorzata Anna Dawgul, Katarzyna Ewa Greber, Sylwia Bartoszewska, Wioletta Baranska-Rybak, Wieslaw Sawicki, Wojciech Kamysz   +5 more
doaj   +1 more source

Synthetische Lipopeptide

, 2009
Lipoproteine mit der N-terminalen Struktur des Trispalmitoyl-Cysteins (Pam3Cys) finden sich in den Membranen einer Vielzahl von Bakterien. Strukturanaloge synthetische Lipopeptide sind zudem Gegenstand intensiver Forschungen bezüglich einer therapeutischen Anwendung als Adjuvantien.
openaire   +2 more sources

MMP2‐Responsive Liposomes Targeting LDLR Enhance the Effectiveness of Anti‐Cancer Drugs in Treating Melanoma

Advanced Therapeutics, Volume 9, Issue 1, January 2026.
A bi‐functional liposomal system is developed to enhance melanoma therapy, combining mApoE‐mediated targeting of LDLR‐expressing tumor cells with MMP2‐responsive drug release. Loaded with Pimasertib, the liposomes improve intracellular delivery, reduce melanoma viability, and inhibit 3D spheroid growth and invasiveness.
Antonio Renda, Antonia I. Antoniou, Marika Quadri, Susanna Comi, Arianna Amenta, Silvia Sesana, Sara Pellegrino, Pierfausto Seneci, Marcus Koch, Vanna Denti, Giuseppe Paglia, Elisabetta Palazzo, Roberta Lotti, Alessandra Marconi, Francesca Re   +14 more
wiley   +1 more source

Immunostimulation by synthetic lipopeptide based vaccine candidates: structure-activity relationships.

Frontiers in Immunology, 2013
Peptide based vaccines offer several advantages over conventional whole organism or protein approaches by offering improved purity and specificity in inducing immune response. However, peptides alone are generally non-immunogenic.
Mehfuz eZaman, Istvan eToth, Istvan eToth   +2 more
doaj   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

Lipopeptides as rhizosphere public goods for microbial cooperation

Microbiology Spectrum
Cyclic lipopeptides (CLPs) are key bioactive secondary metabolites produced by some plant beneficial rhizobacteria such as Pseudomonas and Bacillus. They exhibit antimicrobial properties, promote induced systemic resistance in plants, and support key ...
Augustin Rigolet, Anthony Argüelles Arias, Adrien Anckaert, Loïc Quinton, Sébastien Rigali, Deborah Tellatin, Pierre Burguet, Marc Ongena   +7 more
doaj   +1 more source