Results 111 to 120 of about 7,072 (199)

Hyperlipidemia Impacts Osteogenesis Via Lipophagy Mediated By Optn-Rab18 Interaction

International Dental Journal
Aim or purpose: The high-fat environment impairs osteoblast function and activates lipophagy; however, promoting lipophagy may improve osteogenesis under certain conditions. The underlying mechanisms are unclear.
Chonghao Ji, Xiaoyan Chen, Lehan Xu
doaj   +1 more source

HYPOTHESIS Open Access [PDF]

Hepatic autophagy is differentially regulated in periportal and pericentral zones- a general mechanism relevant for other ...
Paul J Coffer, Rolf Gebhardt
core  

Potential function for the Huntingtin protein as a scaffold for selective autophagy [PDF]

, 2014
Although dominant gain-of-function triplet repeat expansions in the Huntingtin (HTT) gene are the underlying cause of Huntington disease (HD), understanding the normal functions of nonmutant HTT protein has remained a challenge.
Csikos, George, Finkbeiner, Steven, Housman, David E., Humbert, Sandrine, Klionsky, Daniel J., Lau, Alice L., Lukacsovich, Tamas, Mao, Kai, Margulis, Julia, Marsh, J. Lawrence, Ochaba, Joseph, Salazar, Lisa, Saudou, Frederic, Steffan, Joan S., Thompson, Leslie M., Yeung, Sylvia Y., Zeitlin, Scott O., Zheng, Shuqiu   +17 more
core   +1 more source

Neuronal Proteomic Analysis Of The Ubiquitinated Substrates Of The Disease-Linked E3 Ligases Parkin And Ube3a [PDF]

, 2018
Both Parkin and UBE3A are E3 ubiquitin ligases whose mutations result in severe brain dysfunction. Several of their substrates have been identified using cell culture models in combination with proteasome inhibitors, but not in more physiological ...
Arizmendi Bastarrika, Jesús María, Martínez, Aitor, Mayor Martínez, Ugo, Osinalde Moraleja, Nerea, Ramírez Sánchez, Juan Manuel   +4 more
core   +5 more sources

Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses [PDF]

, 2017
Selective autophagy is a catabolic process with which cellular material is specifically targeted for degradation by lysosomes. The function of selective autophagic degradation of self-components in the regulation of innate immunity is still unclear. Here
Bowitz Larsen, Kenneth, Jacomin, Anne-Claire, Jain, Ashish, Johansen, Terje, Nezis, Ioannis P., Penman, Bridget S., Tusco, Radu   +6 more
core   +3 more sources

The cholesterol metabolite 25-hydroxycholesterol suppresses porcine deltacoronavirus via lipophagy inhibition and mTORC1 modulation

Veterinary Research
25-Hydroxycholesterol (25HC) is a hydroxylated cholesterol with multiple antiviral activities, however, little is known about the mechanisms by which 25HC correlates antiviral ability with lipid droplet (LD) dynamic balance to ensure cholesterol ...
Jia-lu Zhang, Xue-fei Wang, Jia-lin Li, Cong Duan, Jiu-feng Wang   +4 more
doaj   +1 more source

Lipophagy: Molecular Mechanisms and Implications in Metabolic Disorders.

Molecules and cells, 2020
Autophagy is an intracellular degradation system that breaks down damaged organelles or damaged proteins using intracellular lysosomes. Recent studies have also revealed that various forms of selective autophagy play specific physiological roles under different cellular conditions.
openaire   +2 more sources

ESCRT machinery mediates selective microautophagy of endoplasmic reticulum in yeast

, 2019
ER-phagy, the selective autophagy of endoplasmic reticulum (ER), safeguards organelle homeostasis by eliminating misfolded proteins and regulating ER size. ER-phagy can occur by macroautophagic and microautophagic mechanisms.
Charlotta Funaya, Dimitrios Papagiannidis, Giulia Ruffini, Jasmin A Schäfer, Julia P Schessner, Katharina Schaeff, Michael Knop, Oliver Pajonk, Peter W Bircham, Sebastian Schuck, Takuma Tsuji, Toyoshi Fujimoto, Vergères G   +12 more
core   +2 more sources

Lipophagy acts as a nutritional adaptation mechanism for the filamentous entomopathogenic fungus Beauveria bassiana to colonize within the hosts

Journal of Advanced Research
Introduction: Metabolic adaptation to various nutrients is crucial for the pathogenic growth and virulence of filamentous fungal pathogens. Despite its importance, the mechanisms underlying fungal adaptation to nutrient shifts, especially at the ...
Jin-Li Ding, Ming-Guang Feng, Sheng-Hua Ying   +2 more
doaj   +1 more source

Quercetin improves hepatic lipid accumulation by up-regulating lipolysis and lipophagy pathways

陆军军医大学学报
Objective To investigate the effect and mechanism of quercetin (QUE) in improving lipid accumulation in hepatocytes by regulating lipolysis and lipophagy pathway.
ZHANG Yan, YANG Yilin, YUAN Jiaqi
doaj   +1 more source