Results 101 to 110 of about 988,006 (285)

Tanshinone IIA suppresses cholesterol accumulation in human macrophages: role of heme oxygenase-1[S]

Journal of Lipid Research, 2014
Accumulation of foam cells in the neointima represents a key event in atherosclerosis. We previously demonstrated that Tanshinone IIA (Tan), a lipophilic bioactive compound extracted from Salvia miltiorrhiza Bunge, inhibits experimental atherogenesis ...
Zhiping Liu, Jiaojiao Wang, Erwen Huang, Si Gao, Hong Li, Jing Lu, Kunming Tian, Peter J. Little, Xiaoyan Shen, Suowen Xu, Peiqing Liu   +10 more
doaj   +1 more source

Bioactivity, hydrophilic, lipophilic and volatile compounds in pulps and skins of Opuntia macrorhiza and Opuntia microdasys fruits

LWT, 2019
Abstract Opuntia genus includes several species able to grow in arid regions and known for producing delicate fruits, which are far from being thoroughly characterized. Herein, fruits from O. macrorhiza and O. microdasys were divided in skins and pulps (without including seeds) and studied for chemical composition, individual phytochemicals and ...
Chahdoura, Hassiba, Barreira, João C.M., Barros, Lillian, Dias, Maria Inês, Calhelha, Ricardo C., Flamini, Guido, Soković, Marina, Achour, Lotfi, Ferreira, Isabel C.F.R.   +8 more
openaire   +5 more sources

Nanostructured Deep Eutectic Systems in Healthcare: From Bioactive Solvents to Intelligent Biointerfaces, Wearables, and AI‐Driven Design

Advanced NanoBiomed Research, EarlyView.
Beyond the green solvent paradigm, this review redefines Deep Eutectic Systems (DES) as programmable supramolecular nanoassemblies. We survey their biomedical convergence: stabilizing thermolabile mRNA to enable cold chain‐free logistics, reshaping transdermal microneedle delivery, enabling long‐term wearables via eutectogels, and utilizing Generative ...
Jeesu Moon, Min Seo Kim, Jae‐Seung Lee
wiley   +1 more source

A Modular Synthesis of C5‐Sulfenyl Thiazoles via an Intermolecular Pummerer Rearrangement: An Underexplored Scaffold for Medicinal Chemistry

Angewandte Chemie, EarlyView.
Modular access to underexplored C5‐sulfenyl thiazoles via an intermolecular Pummerer rearrangement is reported. The methodology exhibits a broad functional group tolerance enabling the seamless design of trisubstituted thiazole cores bearing a sulfur handle for further elaboration.
Joe L. Smy, Theo C. Webb, Barnaby W. Greenland, S. Mark Roe, John Spencer, Storm Hassell‐Hart   +5 more
wiley   +2 more sources

Trends and Future Perspectives of Polysaccharide-Based Bigels from Seeds, Vegetable Oils, and Waxes: A Bibliometric Review

Gels
Gels are semi-solid colloidal systems characterized by three-dimensional networks capable of retaining up to 99% of liquid while exhibiting both solid-like and liquid-like properties.
Monserrat Sanpedro-Díaz, Alitzel Belem García-Hernández, Ana Luisa Gómez-Gómez, Julia Salgado-Cruz, Oswaldo Arturo Ramos-Monroy, Rubén Oliver-Espinoza, Griselda Argelia Rivera-Vargas, Ma de la Paz Salgado-Cruz   +7 more
doaj   +1 more source

Remapping the Synthetic Landscape of α‐Tertiary Alkylamines via Dual‐Functional Catechol

Angewandte Chemie, EarlyView.
A three‐component assembly strategy has been developed for the modular synthesis of hindered α‐tertiary aliphatic amines from readily available precursors through unlocking the dual role of catechol. The practicality of this methodology has been demonstrated in over 90 examples, including compounds that are otherwise difficult to access, along with ...
Chen‐Yan Cai, Yuzuru Kanda, Tian Qin
wiley   +2 more sources

Synthetic Ligands of Cannabinoid Receptors Affect Dauer Formation in the Nematode Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2016
Under adverse environmental conditions the nematode Caenorhabditis elegans can enter an alternate developmental stage called the dauer larva. To identify lipophilic signaling molecules that influence this process, we screened a library of bioactive ...
Pedro Reis Rodrigues, Tiffany K. Kaul, Jo-Hao Ho, Mark Lucanic, Kristopher Burkewitz, William B. Mair, Jason M. Held, Laura M. Bohn, Matthew S. Gill   +8 more
doaj   +1 more source

A compound-target pairs dataset: differences between drugs, clinical candidates and other bioactive compounds [PDF]

Providing a better understanding of what makes a compound a successful drug candidate is crucial for reducing the high attrition rates in drug discovery.
Paul D., Leeson, A. Lina, Heinzke, Barbara, Zdrazil, Robert J., Young, Andrew R., Leach, Axel, Pahl, Herbert, Waldmann   +6 more
core   +1 more source

Valorization of Mexican cabernet sauvignon grape pomace: A source of oil and lipophilic bioactive compounds

Journal of the American Oil Chemists' Society
AbstractThis study presents the first analysis of the lipophilic composition of oil extracted from Mexican Cabernet sauvignon grape pomace in Sonora, using ultrasound‐assisted extraction. The findings reveal a promising oil yield of 7.52%, with linoleic acid dominating the fatty acid profile at 64.72%.
Marcos Leon‐Bejarano, Maribel Ovando‐Martínez, Senay Simsek   +2 more
openaire   +1 more source

Comparison of the Contents of Bioactive Compounds and Quality Parameters in Selected Mango Cultivars

, 2013
Mango cultivars Tommy Atkins, Zill, Peach, Sabre, Rosa and Phiva were analyzed for their quality parameters (fruit weight, flesh color chroma, L, h0, total soluble solid [TSS]/titratable acidity [TA], firmness), bioactive compounds (total phenols ...
Gustavo Alberto Polenta, Dharini Sivakumar, Periyar Selvam Sellamuthu, Denoya, Gabriela Ines, Sivakumar, Dharini, Polenta, Gustavo Alberto, Puffy Soundy, Soundy, Puffy, Gabriela Inés Denoya, Sellamuthu, Periyar Selvam   +9 more
core   +1 more source