Results 121 to 130 of about 988,006 (285)

Bioactive components of fermented soya beans effective against diarrhoea-associated bacteria [PDF]

, 2010
Tempe is a fermented food, obtained by fungal fermentation of soya beans. During the processing specific flavour, texture and nutritional properties are achieved. Previous research has indicated that tempe reduced the incidence and severity of diarrhoea.
Roubos-van den Hil, P.J.
core  

Bioactive peptides with antioxidant and antihypertensive properties, obtained from chachafruto seed flour (Erythrina edulis)

, 2022
: INTRODUCTION Hypertension is an important risk factor for atherosclerosis and therefore predisposes to coronary, cerebrovascular and renal diseases, (Mejías C et al., 2004; Torruco-Uco et al., 2009).
Acevedo Fernández, Juan José, Zapata Montoya, José Edgar, Guerra Almonacid, Carlos Martín   +2 more
core  

Pharmacological Activity of Kaurenoic Acid Nanocarriers and Formulation Considerations for Therapeutic Cancer Applications

Pharmaceutics
Kaurenoic acid (KA) is an ent-kaurane diterpenoid present in several medicinal plant species and has been reported to exhibit anti-inflammatory, cytotoxic, and analgesic activity in experimental models.
Peter Ikechukwu, Remigius Agu
doaj   +1 more source

SARS-CoV-2 Main Protease inhibitors in trace constituents from Algerian herbal medicines using in silico approaches

Фармация и фармакология (Пятигорск)
Since antiquity, еssential oils are considered as a source of bioactive molecules. Some of them have been shown to possess antiviral activities against various virus strains, among them SARS-CoV-2.The aim of this study is the  search for compounds, among
B. Yabrir, A. Belhassan, T. Lakhlifi, G. S. Moran, M. Bouachrine, L. G. Candia   +5 more
doaj   +1 more source

Synthetic Studies on Bioactive Substances: From Research on Water-soluble Compounds to the Field of Lipophilic Ligands

YAKUGAKU ZASSHI
This is a personal review of my chemistry research on retirement from Teikyo University. Under the guidance of Prof. Masaji Ohno of the Faculty of Pharmaceutical Sciences, The University of Tokyo, my research career started with the synthesis of water-soluble basic natural compounds, including the first artificial bleomycin showing potent molecular ...
openaire   +2 more sources

Lipophilic bioactive compounds from thermophilic cyanobacterium Leptolyngbya sp. HNBGU-004: Implications for countering VRSA resistance

Heliyon
Extremophiles thrive in extreme conditions, showcasing rich and unexplored diversity. This resilience hints at the existence of novel biochemical pathways and unique bioactive compounds. In contrast, the issue of drug resistance and excessive misuse of antibiotics in various settings, such as healthcare, agriculture, and veterinary medicine, has ...
Sachin Tyagi, Rahul Kunwar Singh, Ashok Kumar   +2 more
openaire   +3 more sources

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

Angewandte Chemie International Edition, EarlyView.
Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Enhanced delivery potential for lipophilic bioactive compounds of β-lactoglobulin-hyaluronic acid-chlorogenic acid ternary nanocomplexes

Current Research in Food Science
The curcumin (CUR) and lycopene (LYC) have been shown to inhibit the activity of α-amylase and α-glucosidase, but the bioaccessibility and stability are affected by the gastrointestinal environment. In this study, the effect of ultrasound-assisted Maillard reaction and free radical induction methods on the formation of a ternary covalent complex of β ...
Zhang, Mengna, Zhou, Like, Song, Gongshuai, Wang, Danli, Yuan, Tinglan, Li, Ling, Wang, Ziyuan, Gong, Jinyan   +7 more
openaire   +2 more sources

Dosing PPARγ Activation With Light Using Fast Relaxing Photoswitches

Angewandte Chemie International Edition, EarlyView.
To achieve spatiotemporal control over PPARγ activity, we designed the fast‐relaxing photoswitchable agonist 6 that selectively activates PPARγ in its light‐induced Z‐state and relaxes within seconds (t1/2 47 s) to the inactive E‐state. This unique profile allowed light‐dosed receptor activation in in vitro settings, enabling biological studies on ...
Loris Knümann, Alba Rodriguez‐Paniagua, Martin Reynders, Silke Duensing‐Kropp, Oliver Thorn‐Seshold, Vasily Morozov, Julian A. Marschner, Daniel Merk   +7 more
wiley   +1 more source

Valorizing Agro-Industrial By-Products for Sustainable Cultivation of Chlorella sorokiniana: Enhancing Biomass, Lipid Accumulation, Metabolites, and Antimicrobial Potential

Metabolites
Background/Objectives: Mixotrophic cultivation of microalgae using agro-industrial by-products as supplements offers a sustainable strategy to enhance biomass production and bioactive compound synthesis.
Elia Lio, Carlo Esposito, Jacopo Paini, Stefano Gandolfi, Francesco Secundo, Gianluca Ottolina   +5 more
doaj   +1 more source