Results 51 to 60 of about 39,441 (305)

Edible bio-based nanostructures: delivery, absorption and potential toxicity [PDF]

, 2015
The development of bio-based nanostructures as nanocarriers of bioactive compounds to specific body sites has been presented as a hot topic in food, pharmaceutical and nanotechnology fields.
A des Rieux, A Guri, A Hafner, A Lakshmanan, A Manke, A Poma, A Shpigelman, A Totosaus, A Zattoni, AC Hunter, AC Pinheiro, AH Sneharani, AJ Genot, AJ Vander, AL Neal, Ana C. Pinheiro, Ana I. Bourbon, António A. Vicente, AO Elzoghby, AS Karakoti, AV Kabanov, B Díaz, B He, B Kowalczyk, B Loretz, B Sarmento, B Semete, BD Chithrani, BJ Aungst, BS Zolnik, C Blasco, C Chang, C Feng, C Feng, C Giese, C Pinto Reis, C Prego, C Szakal, C Zhu, CB Woitiski, CC Berton-Carabin, CE Mora-Huertas, D Dell’Orco, D Guzey, D Rosenblum, D-W Tang, DJ McClements, DJ McClements, DJ McClements, DV Tatiraju, DY Lai, E Acosta, E Dickinson, E Roger, E Troncoso, EC, EC, EFSA, EFSA, F Kong, F Leonard, F Liu, F Lu, F Wang, F. Xavier Malcata, FE Alemdaroglu, G Joshi, G Sahay, GB Sukhorukov, GK Agrawal, H Bouwmeester, H Kettiger, H Ruh, H Salminen, H Zhang, H-J Doh, HC Fischer, HD Silva, Hélder D. Silva, IJ Joye, IJ Joye, IL Bergin, J Cui, J Lee, J Ma, J Wolfram, J Zhao, J-E Kim, JE Wong, JJ Powell, JK Oh, Joana T. Martins, JP Rao, JPK Tan, JW Loh, K Kesarwani, K Ofokansi, K Sonaje, K Thanki, KB Chalasani, KE Fischer, KL Aillon, KR Vega-Villa, KS Soppimath, L Chen, L Chen, L Donato-Capel, L Hu, L Plapied, L Sagalowicz, L Salvia-Trujillo, L Yan, LL Mercato del, LM Ensign, Lorenzo Pastrana, M Cerqueira, M Delcea, M Desai, M Elsabahy, M Grassi, M Mahmoudi, M Moros, M Motornov, M Rajaonarivony, M Rubinstein, M Sessa, M Subirade, M Torres-Lugo, M Zhaojie, M-C Chen, MA Azevedo, MA Dobrovolskaia, MA Lopes, Melissa C. Rivera, Miguel A. Cerqueira, MJ Buehler, MR Papasani, N Atal, N Khalid, NM Molino, O Akbulut, OE Pérez, P Couvreur, P Kovatcheva-Datchary, P M-M, P Sanguansri, P Zimet, PP Dandekar, Q Peng, R Lima De, R Peters, R Simón-Vázquez, R Wang, RK Das, S Arora, S Drusch, S Dufort, S Patil, S Sharifi, S Vicente, S Xu, SJ Torne, SK Lai, SK Mwilu, SM Krug, SV Vinogradov, T David-Birman, T Jung, T Lozano, T Miller, TPJ Linsinger, W Somchue, WE Hennink, X Li, X Zhang, Y Jin, Y Li, Y Li, Y Liu, Y Luo, Y Sheng, Y Ting, Y Wang, Y Yin, Y-H Lin, Z Liu, Z Teng, Z Teng, Z-H Zhang, África González-Fernández, Óscar L. Ramos   +190 more
core   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Impact of Soil on Biomass Yield and Accumulation of Lipophilic Secondary Metabolites in Four Hypericum Species

Agriculture
The genus Hypericum is a widely distributed ornamental and therapeutic herb known for its diverse bioactive compounds, including xanthones. The levels of secondary metabolites in plants are influenced by the specific plant part, agronomic conditions, and
Ieva Miķelsone, Elise Sipeniece, Inga Mišina, Elvita Bondarenko, Dalija Segliņa, Paweł Górnaś   +5 more
doaj   +1 more source

Mitochondrial Probe Methyltriphenylphosphonium (TPMP) Inhibits the Krebs Cycle Enzyme 2-Oxoglutarate Dehydrogenase.

PLoS ONE, 2016
Methyltriphenylphosphonium (TPMP) salts have been widely used to measure the mitochondrial membrane potential and the triphenylphosphonium (TPP+) moiety has been attached to many bioactive compounds including antioxidants to target them into mitochondria
Moustafa Elkalaf, Petr Tůma, Martin Weiszenstein, Jan Polák, Jan Trnka   +4 more
doaj   +1 more source

Pharmacokinetics-Driven Evaluation of the Antioxidant Activity of Curcuminoids and Their Major Reduced Metabolites—A Medicinal Chemistry Approach

Molecules, 2021
Curcuminoids are the main bioactive components of the well-known Asian spice and traditional medicine turmeric. Curcuminoids have poor chemical stability and bioavailability; in vivo they are rapidly metabolized to a set of bioreduced derivatives and/or ...
Gábor Girst, Sándor B. Ötvös, Ferenc Fülöp, György T. Balogh, Attila Hunyadi   +4 more
doaj   +1 more source

Searching for bioactive conformations of drug-like ligands with current force fields: how good are we? [PDF]

, 2017
Drug-like ligands obtained from protein–ligand complexes deposited in the Protein Databank were subjected to conformational searching using various force fields and solvation settings.
Gürsoy, Oya, Smieško, Martin
core   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Valorization of extracts from maqui (Aristotelia chilensis) and calafate (Berberis microphylla) biowaste blends by supercritical fluid and pressurized liquid extraction

Journal of Agriculture and Food Research
Maqui and calafate biowastes were fractionated using emerging technologies such as supercritical fluid extraction (SFE) and pressurized liquid extraction (PLE) to obtain bioactive compounds.
Horacio Fraguela-Meissimilly, José Miguel Bastías-Montes, Jaime Alejandro Ortiz-Viedma, Yanara Tamarit-Pino, Marcelino Claret-Merino, Jacqueline Araneda-Flores   +5 more
doaj   +1 more source

Cryptotanshinone attenuates LPS-induced acute lung injury by regulating metabolic reprogramming of macrophage

Frontiers in Medicine, 2023
BackgroundAcute lung injury (ALI) is a life-threatening inflammatory disease without effective therapeutic regimen. Macrophage polarization plays a key role in the initiation and resolution of pulmonary inflammation.
Zesen Ye, Panxia Wang, Guodong Feng, Quan Wang, Cui Liu, Jing Lu, Jianwen Chen, Peiqing Liu   +7 more
doaj   +1 more source

Epigenetic and antitumor effects of platinum(IV)-octanoato conjugates [PDF]

, 2017
We present the anticancer properties of cis, cis, trans-[Pt(IV)(NH3)2Cl2(OA)2] [Pt(IV)diOA] (OA = octanoato), Pt(IV) derivative of cisplatin containing two OA units appended to the axial positions of a six-coordinate Pt(IV) center.
Brabec, Viktor, Gandin, Valentina, Gibson, Dan, Kasparkova, Jana, Marzano, Cristina, Novohradsky, Vojtech, Osella, Domenico, Pracharova, Jitka, Zanellato, Ilaria   +8 more
core   +1 more source