Results 61 to 70 of about 991,719 (279)

Cryptotanshinone attenuates LPS-induced acute lung injury by regulating metabolic reprogramming of macrophage

Frontiers in Medicine, 2023
BackgroundAcute lung injury (ALI) is a life-threatening inflammatory disease without effective therapeutic regimen. Macrophage polarization plays a key role in the initiation and resolution of pulmonary inflammation.
Zesen Ye, Panxia Wang, Guodong Feng, Quan Wang, Cui Liu, Jing Lu, Jianwen Chen, Peiqing Liu   +7 more
doaj   +1 more source

Enantioselective Access to Trifluoromethylated Spirocyclopropyl Heterocycles

Advanced Science, EarlyView.
We report a rhodium‐catalyzed asymmetric [2+1] spirocyclopropanation of methylene azacycles with trifluoromethyl carbenes in situ derived from fluoroalkyl triftosylhydrazones. ABSTRACT Chiral spirocyclopropyl heterocycles have emerged as privileged three‐dimensional structural motifs in medicinal chemistry.
Yuanhao Zhu, Youzhi Xu, Weitao Zhang, Yongyue Ning, Yaojia Jiang, Yongquan Ning, Genping Huang, Jiawei Cheng, Paramasivam Sivaguru, Xihe Bi   +9 more
wiley   +1 more source

Pharmacokinetics-Driven Evaluation of the Antioxidant Activity of Curcuminoids and Their Major Reduced Metabolites—A Medicinal Chemistry Approach

Molecules, 2021
Curcuminoids are the main bioactive components of the well-known Asian spice and traditional medicine turmeric. Curcuminoids have poor chemical stability and bioavailability; in vivo they are rapidly metabolized to a set of bioreduced derivatives and/or ...
Gábor Girst, Sándor B. Ötvös, Ferenc Fülöp, György T. Balogh, Attila Hunyadi   +4 more
doaj   +1 more source

Correction to Impact of Lipophilic Efficiency on Compound Quality

, 2016
Correction to Impact of Lipophilic Efficiency on Compound ...
György M. Keserű (1269681), Ákos Tarcsay (1880113), Kinga Nyíri (1970830)   +2 more
core   +1 more source

Pigmented Rice Bioactive Compound Possible Mechanism from Breast Cancer.

, 2023
Pigmented Rice Bioactive Compound Possible Mechanism from Breast Cancer.
Alexander Patera Nugraha (9084650)
core   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Tocopherol and Tocotrienol Content in the Leaves of the Genus Hypericum: Impact of Species and Drying Technique

Plants
α-Tocopherol (α-T) predominates in photosynthetic tissues, while tocotrienols (T3s) are reported very rarely. The genus Hypericum stands out as one of the few exceptions.
Ieva Miķelsone, Elise Sipeniece, Dalija Segliņa, Paweł Górnaś   +3 more
doaj   +1 more source

Exploring the mode of action of bioactive compounds by microfluidic transcriptional profiling in mycobacteria. [PDF]

, 2013
Most candidate anti-bacterials are identified on the basis of their whole cell anti-bacterial activity. A critical bottleneck in the early discovery of novel anti-bacterials is tracking the structure activity relationship (SAR) of the novel compounds ...
Thomas Dick, Boshoff, Helena IM, Martin L. Hibberd, Ahmad Nazri Mohamed Naim, Martin L Hibberd, Vivian Lim (440158), de Sessions, Paola Florez, Helena I M Boshoff, de Sessions, P.F., Ahmad Nazri, Vasan K. Samb, de Sessions Paola Florez, Bifani, Pablo, Pablo Bifani, Vasan K Sambandamurthy, Paul Murima (440156), Dick Thomas, Sambandamurthy Vasan K., Pablo Bifani (89686), Murima Paul, Lim, Vivian, Sambandamurthy, Vasan K, Boshoff, H.I.M., Helena I. M. Boshoff, Murima, Paul, Hibberd, M.L., Dick, T., Vasan K. Sambandamurthy (440161), Rao, S.P.S., Naim, A.N.M., Thomas Dick (284563), Rao, Srinivasa PS, Srinivasa P. S. Rao, Paola Florez de Sessions (440157), Naim, Ahmad Nazri Mohamed, Naim Ahmad Nazri Mohamed, Boshoff Helena I. M., Hibberd Martin L., Murima, P., Mohamed Naim, Vivian Lim, Srinivasa P S Rao, Dick, Thomas, Sambandamurthy, V.K., Schreiber, M., Bifani Pablo, Lim Vivian, Lim, V., Schreiber Mark, Helena I. M. Boshoff (440160), Bifani, P., Paola Florez de Sessions, Mark Schreiber, Ahmad Nazri Mohamed Naim (440159), Paul Murima, Martin L. Hibberd (167212), Mark Schreiber (272302), Hibberd, Martin L, Schreiber, Mark, Srinivasa P. S. Rao (284562), Rao Srinivasa P. S.   +60 more
core   +2 more sources

Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure

Advanced Science, EarlyView.
Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye, Jiamin Wu, Zixin Wu, Xi Liu, Jiajia Luo, Leyi Yang, Peng Shi   +6 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources