Results 61 to 70 of about 988,006 (285)

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Bioactive ceramic-reinforced composites for bone augmentation [PDF]

, 2010
Biomaterials have been used to repair the human body for millennia, but it is only since the 1970s that man-made composites have been used. Hydroxyapatite (HA)-reinforced polyethylene (PE) is the first of the ‘second-generation’ biomaterials that have ...
K. E. Tanner, Tanner, K.E.
core   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

A Blood‐Derived Double‐Network Hydrogel with Robust Wet Adhesion for Keratinized Mucosa Regeneration via Neutrophil Phenotype Reprogramming and Mechanophysical Niche Modulation

Advanced Science, EarlyView.
The iPRF‐MA/Alg‐NHS/Lut@EGCG (PGAE) double‐network hydrogel achieves durable wet adhesion in the oral environment. It simultaneously reprograms neutrophils from NETosis to phagocytosis for biofilm clearance, and activates the FAK‐RhoA‐YAP mechanotransduction pathway in gingival fibroblasts to drive extracellular matrix remodeling, thereby promoting ...
Sicong Ren, Xinting Yang, Jingxia Chen, Yihan Wang, Jian Feng, Jing Zhou, Jiaxin Luo, Jingjie Zhai, Quan Lin, Yanmin Zhou   +9 more
wiley   +1 more source

Tocopherol and Tocotrienol Content in the Leaves of the Genus Hypericum: Impact of Species and Drying Technique

Plants
α-Tocopherol (α-T) predominates in photosynthetic tissues, while tocotrienols (T3s) are reported very rarely. The genus Hypericum stands out as one of the few exceptions.
Ieva Miķelsone, Elise Sipeniece, Dalija Segliņa, Paweł Górnaś   +3 more
doaj   +1 more source

Correction to Impact of Lipophilic Efficiency on Compound Quality

, 2016
Correction to Impact of Lipophilic Efficiency on Compound ...
György M. Keserű (1269681), Ákos Tarcsay (1880113), Kinga Nyíri (1970830)   +2 more
core   +1 more source

Pigmented Rice Bioactive Compound Possible Mechanism from Breast Cancer.

, 2023
Pigmented Rice Bioactive Compound Possible Mechanism from Breast Cancer.
Alexander Patera Nugraha (9084650)
core   +1 more source

A Plant Photoregulator‐Inspired S‐Type Heterojunction System for Diabetic Keratopathy via Tri‐Modal Light‐Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity

Advanced Science, EarlyView.
To address the multifaceted imbalance in diabetic keratopathy, a light‐responsive biomimetic platform (WCNx‐Rh2) is developed and integrates glucose degradation, immune modulation, and antibacterial defense through a designed heterojunction and screened immunomodulator. WCNx‐Rh2 reduces AGEs/ROS and inflammatory signaling, reprogramming dendritic cells
Mengzhen Zhao, Zhibin Zhou, Yuxuan Wei, Xiangfan Huang, Zhiyong Zhou, Jiaheng Chen, Haoxin Cheng, Xiaotian Hu, Xiaolei Wang   +8 more
wiley   +1 more source

Exploring the mode of action of bioactive compounds by microfluidic transcriptional profiling in mycobacteria. [PDF]

, 2013
Most candidate anti-bacterials are identified on the basis of their whole cell anti-bacterial activity. A critical bottleneck in the early discovery of novel anti-bacterials is tracking the structure activity relationship (SAR) of the novel compounds ...
Thomas Dick, Boshoff, Helena IM, Martin L. Hibberd, Ahmad Nazri Mohamed Naim, Martin L Hibberd, Vivian Lim (440158), de Sessions, Paola Florez, Helena I M Boshoff, de Sessions, P.F., Ahmad Nazri, Vasan K. Samb, de Sessions Paola Florez, Bifani, Pablo, Pablo Bifani, Vasan K Sambandamurthy, Paul Murima (440156), Dick Thomas, Sambandamurthy Vasan K., Pablo Bifani (89686), Murima Paul, Lim, Vivian, Sambandamurthy, Vasan K, Boshoff, H.I.M., Helena I. M. Boshoff, Murima, Paul, Hibberd, M.L., Dick, T., Vasan K. Sambandamurthy (440161), Rao, S.P.S., Naim, A.N.M., Thomas Dick (284563), Rao, Srinivasa PS, Srinivasa P. S. Rao, Paola Florez de Sessions (440157), Naim, Ahmad Nazri Mohamed, Naim Ahmad Nazri Mohamed, Boshoff Helena I. M., Hibberd Martin L., Murima, P., Mohamed Naim, Vivian Lim, Srinivasa P S Rao, Dick, Thomas, Sambandamurthy, V.K., Schreiber, M., Bifani Pablo, Lim Vivian, Lim, V., Schreiber Mark, Helena I. M. Boshoff (440160), Bifani, P., Paola Florez de Sessions, Mark Schreiber, Ahmad Nazri Mohamed Naim (440159), Paul Murima, Martin L. Hibberd (167212), Mark Schreiber (272302), Hibberd, Martin L, Schreiber, Mark, Srinivasa P. S. Rao (284562), Rao Srinivasa P. S.   +60 more
core   +2 more sources

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source