Results 31 to 40 of about 84,571 (285)

Preparation and Hydro-Lipophilic Properties of Monosubstituted N-Aryl-4-hydroxyquinoline-3-carboxanilides

Chemistry Proceedings, 2022
A series of twenty-two monosubstituted N-aryl-4-hydroxyquinoline-3-carboxanilides designed as dual anti-invasive agents was prepared and characterized. Lipophilicity significantly affects biological activities of compounds and ADME properties; therefore,
Tomas Gonec, Lucia Vrablova, Dominika Pindjakova, Tomas Strharsky, Michal Oravec, Josef Jampilek   +5 more
doaj   +1 more source

Standardized Chromatographic and Computational Approaches for Lipophilicity Analysis of Five Gliflozin Antidiabetic Drugs in Relation to Their Biological Activity

Molecules
This study represents the first-time experimental analysis of lipophilicity for antidiabetic drugs from the gliflozin class using chromatographic methods alongside computational approaches.
Anna Gumieniczek, Anna Berecka-Rycerz, Marcelina Dul, Aleksandra Pryjda   +3 more
doaj   +1 more source

The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by Thin Layer Chromatography

Journal of Chemistry, 2013
Mercaptopurine and its derivatives are used in the treatment of leukemia. To estimate their lipophilicity, a simple and novel thin layer chromatography method was developed. The mobile phase was the mixture of acetonitrile and water.
Andrzej Czyrski, Bartłomiej Kupczyk
doaj   +1 more source

Nanopartículas Poliméricas en Dermocosmética [PDF]

, 2015
Indexación: Web of Science; Scielo.Recent advances in the fields of biomaterials and nanotechnology have allowed the development of advanced nanoparticles for biomedical applications. Despite a vast number of nanostructures such as liposomes, solid­lipid
Bahamonde-Norambuena, D., Cantin, Mario, Molina-Pereira, A., Muñoz, M., Vilos, Cristian, Zepeda, Katherine   +5 more
core   +1 more source

Assessment of Bioavailability Parameters of Mono- and Bistriazole Derivatives of Propynoylbetulin

Applied Sciences
Bioavailability describes the properties that determine the passage of a compound through biological barriers. In many cases, bioavailability depends on the lipophilicity of the compound.
Monika Kadela-Tomanek, Arkadiusz Sokal, Klaudia Stocerz, Ewa Bębenek, Elwira Chrobak, Paweł Olczyk   +5 more
doaj   +1 more source

Investigation of Hydro-Lipophilic Properties of N-Alkoxyphenylhydroxynaphthalenecarboxamides †

Molecules, 2018
The evaluation of the lipophilic characteristics of biologically active agents is indispensable for the rational design of ADMET-tailored structure–activity models.
Iva Kapustikova, Andrzej Bak, Tomas Gonec, Jiri Kos, Violetta Kozik, Josef Jampilek   +5 more
doaj   +1 more source

Current and evolving approaches for improving the oral permeability of BCS Class III or analogous molecules [PDF]

, 2016
The Biopharmaceutics Classification System (BCS) classifies pharmaceutical compounds based on their aqueous solubility and intestinal permeability. The BCS Class III compounds are hydrophilic molecules (high aqueous solubility) with low permeability ...
Dave, Vivek S, Gupta, Deepak, Gupta, Sheeba Varghese, Nguyen, Phong, Yu, Monica   +4 more
core   +2 more sources

MODELING AND PREDICTION OF AMINO ACIDS LIPOPHYLICITY USING MULTIPLE LINEAR REGRESSION COUPLED WITH GENETIC ALGORITHM

Studia Universitatis Babes-Bolyai Chemia, 2019
Quantitative structure-retention relationships (QSRR) approach was used to model chromatographic lipophilicity of sixteen proteinogenic amino acids using molecular descriptors computed with DRAGON and ALCHEMY software packages.
Alexandrina GUIDEA, Costel SÂRBU
doaj   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Structure-Activity and Lipophilicity Relationships of Selected Antibacterial Natural Flavones and Flavanones of Chilean Flora

Molecules, 2017
In this study, we tested eight naturally-occurring flavonoids—three flavanones and five flavones—for their possible antibacterial properties against four Gram-positive and four Gram-negative bacteria.
Javier Echeverría, Julia Opazo, Leonora Mendoza, Alejandro Urzúa, Marcela Wilkens   +4 more
doaj   +1 more source