Results 51 to 60 of about 733,256 (293)

Chemokine receptor 4 (CXCR4) is part of the lipopolysaccharide “sensing apparatus” [PDF]

European Journal of Immunology, 2007
AbstractRecognition of bacterial lipopolysaccharide (LPS) by the innate immune system involves at least three receptor molecules: CD14, TLR4 and MD‐2. Additional receptor components such as heat shock proteins, chemokine receptor 4 (CXCR4), or CD55 have been suggested to be part of this activation cluster; possibly acting as additional LPS transfer ...
Triantafilou, Martha, Lepper, Philipp, Briault, Caspar David, Ahmed, Mohamed Abd Elrahman, Dmochowski, Josh M, Schumann, Christian, Triantafilou, Kathy   +6 more
openaire   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Unravelling the anti-inflammatory mechanisms of dietary fatty acids [PDF]

, 2009
Polyunsaturated fatty acids (PUFA) have been shown to modulate immune responses and have therapeutic effects in inflammatory disorders. The specific mechanisms of their actions have yet to be defined.
Dowling, Jennifer K.
core   +2 more sources

Novel biphasic role of lipoxinA4 on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts [PDF]

, 2011
Fibroblasts are important to host defence and immunity, can also as initiators of inflammation as well. As the endogenous "braking signal", Lipoxins can regulate anti-inflammation and the resolution of inflammation.
Gao, F., Song, X. R., QingQuan Lian, Jin, Shengwei, Shengxing Zheng, Duyun Ye, He, Q., Fang Gao, Jin, S. W., Gao, Fang; id_orcid, Xiaorong Song, He, Qian, Qian Wang, Ye, Duyun, Wang, Q., Zheng, Shengxing, Ye, D. Y., Lian, Q. Q., Lian, QingQuan, Shengwei Jin, Song, Xiaorong, Qian He, Wang, Qian, Smith, F. Gao (Fang Gao), Zheng, S. X.   +24 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

A study of the modulation of Toll-like receptor signalling in macrophages by Annexin-1 [PDF]

, 2010
PhDAnnexin-A1 (AnxA1) is an endogenous anti-inflammatory protein that has been shown to exert a protective role against the lethal effects induced by the Toll-like receptor (TLR) 4 agonist lipopolysaccharide (LPS).
Polycarpou, Anastasia
core   +4 more sources

Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberis [PDF]

, 2004
Streptococcus uberis and Serratia marcescens are Gram-positive and Gram-negative bacteria, respectively, that induce clinical mastitis. Once initial host barrier systems have been breached by these pathogens, the innate immune system provides the next ...
Bannerman, Douglas, Goff, JP, Goff, Jesse P, Lippolis, JD, John D. Lippolis, Paape, Max, Bannerman, Douglas D, Paape, Max J, Kimura, K, Jayne C. Hope, Hope, Jayne C, Kimura, Kayoko, Lippolis, John D, Douglas D. Bannerman, Max J. Paape, Lippolis, John, Hope, Jayne, Kayoko Kimura, Hope, Jayne; id_orcid, Jesse P. Goff, Goff, Jesse   +20 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Cytokine production and signaling pathways in respiratory virus infection

Frontiers in Microbiology, 2013
It has been confirmed that respiratory virus infections can induce abberant cytokine production in the host. These cytokines may be associated with both elimination of the virus and complications in the host, such as virus-induced asthma.
Hirokazu eKimura, Masakazu eYoshizumi, Haruyuki eIshii, Kazunori eOishi, Akihide eRyo   +4 more
doaj   +1 more source

The Specificity and Broad Multitarget Properties of Ligands for the Free Fatty Acid Receptors FFA3/GPR41 and FFA2/GPR43 and the Related Hydroxycarboxylic Acid Receptor HCA2/GPR109A

Pharmaceuticals, 2021
The paradigm of ligand-receptor interactions postulated as “one compound—one target” has been evolving; a multi-target, pleiotropic approach is now considered to be realistic. Novel series of 1,4,5,6,7,8-hexahydro-5-oxoquinolines, pyranopyrimidines and S-
Egils Bisenieks, Brigita Vigante, Ramona Petrovska, Baiba Turovska, Ruslan Muhamadejev, Vitalijs Soloduns, Astrida Velena, Karlis Pajuste, Luciano Saso, Janis Klovins, Gunars Duburs, Ilona Mandrika   +11 more
doaj   +1 more source