Results 71 to 80 of about 124,080 (260)

Neuronal toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro

Journal of Neuroinflammation, 2012
Background The innate immune response in the brain is initiated by pathogen-associated molecular patterns (PAMPS) or danger-associated molecular patterns (DAMPS) produced in response to central nervous system (CNS) infection or injury.
Leow-Dyke Sophie, Allen Charlotte, Denes Adam, Nilsson Olov, Maysami Samaneh, Bowie Andrew G, Rothwell Nancy J, Pinteaux Emmanuel   +7 more
doaj   +1 more source

Recognition of Receptor Lipopolysaccharides by Spike G Protein of Bacteriophage φX174

Bioscience, Biotechnology, and Biochemistry, 2000
The spike G protein of bacteriophage phiX174 was prepared as a hexa histidine-tagged G protein (HisG). In the enzyme-linked plate assay, HisG bound specifically to lipopolysaccharides (LPSs) of the phiX174-sensitive strains, and did not bind to LPSs of the phiX174-insensitive strains. The truncated G protein obtained after trypsin digestion of HisG had
KAWAURA, Tomoko, INAGAKI, Minoru, KARITA, Shuichi, KATO, Muneharu, NISHIKAWA, Shiro, KASHIMURA, Naoki   +5 more
openaire   +2 more sources

Nanoporous Silica Embedded in Nanoporous Platinum: A Versatile Composite Coating for Implant‐Associated Drug Delivery From Neuronal Electrodes

Advanced Materials Technologies, EarlyView.
Nanoporous silica nanoparticles incorporated in nanoporous platinum offer the possibility for implant‐associated drug delivery from neuronal electrodes. ABSTRACT Sensorineural hearing loss, resulting from damage to the hair cells of the inner ear, profoundly impairs quality of life.
Mosaieb Habib, Tim‐Joshua Strauß, Jennifer Harre, Madeleine Goblet, Florian Klodwig‐Kirstein, Jana Schwieger, Michaela Kreienmeyer, Verena Scheper, Athanasia Warnecke, Nina Ehlert, Peter Behrens   +10 more
wiley   +1 more source

Endotoxin-Induced Inflammation Suppresses the Effect of Melatonin on the Release of LH from the Ovine Pars Tuberalis Explants—Ex Vivo Study

Molecules, 2017
The secretion of the hormone melatonin reliably reflects environmental light conditions. Among numerous actions, in seasonal breeders, melatonin may regulate the secretion of the gonadotropins acting via its corresponding receptors occurring in the Pars ...
Karolina Wojtulewicz, Dorota Tomaszewska-Zaremba, Andrzej Przemysław Herman   +2 more
doaj   +1 more source

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
wiley   +1 more source

Gut flora enhance bacterial clearance in lung through toll-like receptors 4

Journal of Biomedical Science, 2011
Background The influence of the gut flora on lung inflammatory reaction against bacterial challenge remains undefined. This study was designed to investigate whether gut flora enhances lung defense against E.coli pneumonia through TLR4 signaling. Methods
Hsu Ching-Mei, Chen Pei-Hsuan, Yang Ming-Chieh, Tsay Tzyy-Bin, Chen Lee-Wei   +4 more
doaj   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

THREE-DIMENSIONAL MAPPING OF DIFFERENTIAL AMINO ACIDS OF HUMAN, MURINE, CANINE AND EQUINE TLR4/MD-2 RECEPTOR COMPLEXES CONFERRING ENDOTOXIC ACTIVATION BY LIPID A, ANTAGONISM BY ERITORAN AND SPECIES-DEPENDENT ACTIVITIES OF LIPID IVA IN THE MAMMALIAN LPS SENSOR SYSTEM

Computational and Structural Biotechnology Journal, 2013
A literature review concerning the unexpected species differences of the vertebrate innate immune response to lipid IVA was published in CSBJ prior to the present computational study to address the unpaired activity-sequence correlation of prototypic E ...
Thomas Scior, Jorge Lozano-Aponte, Vianihuini Figueroa-Vazquez, Julian A. Yunes-Rojas, Ulrich Zähringer, Christian Alexander   +5 more
doaj   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Mitigating LPS-Induced Inflammation in AGS Cells via the TLR4 Pathway with Fumaric Acids [PDF]

Journal of Epigenetics
The study investigates the effects of fumaric acid on Toll-like receptor (TLR) expression, cytokine production, and cell viability in AGS cells exposed to lipopolysaccharide (LPS), a potent inducer of inflammation.
pouya Moradi, Forouzan Ghasemian Rodsari, Elahe Gholamiian, Parsa Dorani, Fatemeh Seyed Monfared Zanjani, abbas bahari   +5 more
doaj   +1 more source