Results 1 to 10 of about 240,277 (117)

Lipoprotein metabolism indicators improve cardiovascular risk prediction. [PDF]

PLoS ONE, 2014
BACKGROUND: Cardiovascular disease risk increases when lipoprotein metabolism is dysfunctional. We have developed a computational model able to derive indicators of lipoprotein production, lipolysis, and uptake processes from a single lipoprotein profile
Daniël B van Schalkwijk, Albert A de Graaf, Evgeni Tsivtsivadze, Laurence D Parnell, Bianca J C van der Werff-van der Vat, Ben van Ommen, Jan van der Greef, José M Ordovás   +7 more
doaj   +3 more sources

A computational model for the analysis of lipoprotein distributions in the mouse: translating FPLC profiles to lipoprotein metabolism.

PLoS Computational Biology, 2014
Disturbances of lipoprotein metabolism are recognized as indicators of cardiometabolic disease risk. Lipoprotein size and composition, measured in a lipoprotein profile, are considered to be disease risk markers.
Fianne L P Sips, Christian A Tiemann, Maaike H Oosterveer, Albert K Groen, Peter A J Hilbers, Natal A W van Riel   +5 more
doaj   +3 more sources

Effects of HA1, a probucol analogue, and APOC3 siRNA on lipoprotein and amyloid-β metabolism and neurovascular dysfunction in type 2 diabetic mice [PDF]

Frontiers in Pharmacology
IntroductionChronic vascular exposure to elevated levels of lipoprotein-amyloid-β (Aβ) contributes to blood–brain barrier (BBB) disruption and the pathogenesis of Alzheimer’s disease (AD).
Arazu Sharif, Arazu Sharif, Arazu Sharif, John Charles Louis Mamo, John Charles Louis Mamo, John Charles Louis Mamo, Virginie Lam, Virginie Lam, Virginie Lam, Giuseppe Luna, Giuseppe Luna, Gerald F. Watts, Gerald F. Watts, Michael Leo Nesbit, Hani Al-Salami, Hani Al-Salami, Armin Mooranian, Armin Mooranian, Ryusuke Takechi, Ryusuke Takechi, Ryusuke Takechi   +20 more
doaj   +2 more sources

The kringle IV type 2 domain variant 4925G>A causes the elusive association signal of the LPA pentanucleotide repeat

Journal of Lipid Research, 2022
Lipoprotein(a) [Lp(a)] concentrations are regulated by the LPA gene mainly via the large kringle IV-type 2 (KIV-2) copy number variation and multiple causal variants.
Rebecca Grüneis, Hansi Weissensteiner, Claudia Lamina, Sebastian Schönherr, Lukas Forer, Silvia Di Maio, Gertraud Streiter, Annette Peters, Christian Gieger, Florian Kronenberg, Stefan Coassin   +10 more
doaj   +1 more source

Reducing saturated fat intake lowers LDL-C but increases Lp(a) levels in African Americans: the GET-READI feeding trial

Journal of Lipid Research, 2023
Reducing dietary saturated fatty acids (SFA) intake results in a clinically significant lowering of low-density lipoprotein cholesterol (LDL-C) across ethnicities.
Hayley G. Law, Muhammad A. Khan, Wei Zhang, Heejung Bang, Jennifer Rood, Marlene Most, Michael Lefevre, Lars Berglund, Byambaa Enkhmaa   +8 more
doaj   +1 more source

Dietary fish oil enriched in very-long-chain polyunsaturated fatty acid reduces cardiometabolic risk factors and improves retinal function

iScience, 2023
Summary: Very-long-chain polyunsaturated fatty acids (VLCPUFAs; C24-38) constitute a unique class of PUFA that have important biological roles, but the lack of a suitable dietary source has limited research in this field.
Zhi-Hong Yang, Aruna Gorusupudi, Todd A. Lydic, Anupam K. Mondal, Seizo Sato, Isao Yamazaki, Hideaki Yamaguchi, Jingrong Tang, Krishna Vamsi Rojulpote, Anna B. Lin, Hannah Decot, Hannah Koch, Daniel C. Brock, Ranganathan Arunkumar, Zhen-Dan Shi, Zu-Xi Yu, Milton Pryor, Julia F. Kun, Rolf E. Swenson, Anand Swaroop, Paul S. Bernstein, Alan T. Remaley   +21 more
doaj   +1 more source

A new phenotypic classification system for dyslipidemias based on the standard lipid panel

Lipids in Health and Disease, 2021
Highlights A new algorithm is described for categorizing dyslipidemic patients into Fredrickson-like lipoprotein phenotypes except for Type III. The new lipoprotein phenotypes were validated by NMR-lipoprotein analysis and by agarose gel electrophoresis ...
Maureen Sampson, Rami A. Ballout, Daniel Soffer, Anna Wolska, Sierra Wilson, Jeff Meeusen, Leslie J. Donato, Erica Fatica, James D. Otvos, Eliot A. Brinton, Robert S. Rosenson, Peter Wilson, Marcelo Amar, Robert Shamburek, Sotirios K. Karathanasis, Alan T. Remaley   +15 more
doaj   +1 more source

Influence of proteinuria on the lipoprotein (a) metabolism disorder [PDF]

Vojnosanitetski Pregled, 2005
Background/Aim. Proteinuria causes lipid metabolism abnormalities. The aim of the present study was to examine the influence of proteinuria on the lipoprotein (a) metabolism disorder. Methods.
Petrović Dejan, Obrenović Radmila, Stojimirović Biljana   +2 more
doaj   +1 more source

Causal associations between disorders of lipoprotein metabolism and ten cardiovascular diseases

Frontiers in Cell and Developmental Biology, 2022
Disorders of lipoprotein metabolism have been linked with an increased risk of cardiovascular diseases (CVDs) but the causal association is unclear. In this study, we investigated the causal association between disorders of lipoprotein metabolism and ...
Qiannan Gao, Jiang-Shan Tan, Luyun Fan, Xiaoqi Wang, Lu Hua, Jun Cai   +5 more
doaj   +1 more source

New Insights Into the Regulation of Lipoprotein Metabolism by PCSK9: Lessons From Stable Isotope Tracer Studies in Human Subjects

Frontiers in Physiology, 2021
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a convertase enzyme mostly produced by the liver. It is a key regulator of LDL metabolism because of its ability to enhance degradation of the LDL receptor.
Qidi Ying, Dick C. Chan, Gerald F. Watts, Gerald F. Watts   +3 more
doaj   +1 more source