Results 181 to 190 of about 115,025,331 (252)

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Changes in Lipoprotein Fractions and Lipoprotein-Associated Alpha-Tocopherol After Sleeve Gastrectomy in Patients With Severe Obesity. [PDF]

Cardiol Res
Katsuyama H, Hirowatari Y, Manita D, Iwasaki T, Yoshio S, Inamine S, Hakoshima M, Kawaguchi T, Yanai H.   +8 more
europepmc   +1 more source

Triglyceride Polygenic Score Identifies Individuals Who May Respond Differently to Aspirin in Primary Prevention

Clinical Pharmacology &Therapeutics, EarlyView.
Low‐dose aspirin is no longer routinely recommended for the primary prevention of cardiovascular disease in older adults due to a lack of net benefit over bleeding risk. We hypothesized that genetic subgroups may experience differential harm or benefit from aspirin therapy.
Peter D. Fransquet, Chenglong Yu, Cammie Tran, Sultana Monira Hussain, Chad A. Bousman, Mark R. Nelson, Andrew M. Tonkin, John J. McNeil, Paul Lacaze   +8 more
wiley   +1 more source

Effect of pemafibrate on LDL-cholesterol properties in type 2 diabetes and hypertriglyceridemia by lipid management status: PARM-T2D post hoc analysis. [PDF]

J Diabetes Investig
Kitsunai H, Kito K, Omori K, Cho KY, Nakamura A, Takeuchi J, Nagai S, Sakuma I, Nomoto H.   +8 more
europepmc   +1 more source

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, EarlyView.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

Cholesterol Metabolism in Cancer Patients: Mechanisms, Treatment-Related Effects, and Cardio-Oncology Management. [PDF]

Oncol Res
Piscione M, Pala B, Cribari F, Gualtieri P, Gaudio D, Perrone MA, Di Renzo L.   +6 more
europepmc   +1 more source

Impact of Drone Versus Car Transport on Anti‐Doping Sample Integrity Over Short Distances: A Proof‐Of‐Concept Study

Drug Testing and Analysis, EarlyView.
This proof‐of‐concept study evaluated the impact of short‐distance drone transport on anti‐doping sample integrity compared with traditional car transport. Targeted assays and untargeted metabolomics revealed equivalent biological profiles between methods, confirming that drone delivery preserves sample integrity for the athlete biological passport ...
I. Al‐Mohannadi, M. Y. Al‐Jaber, M. Al‐Nesf, W. Samsam, Abdulaziz Farooq, N. M. Thomas, M. Stuart, N. Robinson, G. Zangenfeind, D. Rovira, N. Mohamed‐Ali, A. Beotra, V. Mohamed‐Ali, M. Al‐Maadheed   +13 more
wiley   +1 more source

Evaluation of the first trimester maternal glycolipid profile on gestational diabetes mellitus: a case-control study in the hospital of rural Shanghai. [PDF]

BMJ Open
Li H, Zhang H, Ding L, Zhu J, Mi G, Li P, Wu J, Shen Y, Wu S, Jiang L.   +9 more
europepmc   +1 more source

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble, Samantha L. Payne, Matthew K. Vickaryous   +2 more
wiley   +1 more source

Regulatory Bottlenecks Linking HDL Dysfunction, Inflammation, and Oxidative Stress: A Petri Net-Based Systems Analysis. [PDF]

Int J Mol Sci
Formanowicz D, Rynkiewicz AA, Formanowicz P.   +2 more
europepmc   +1 more source