Results 231 to 240 of about 28,679 (286)

Mechanistic insights into how intrapancreatic fat deposition drives the development of acute pancreatitis. [PDF]

Int J Biol Sci
Gu X, Zhang H, Lin W, Chen W, Le C, Huang Z, Liu Q, Yang J.   +7 more
europepmc   +1 more source

TAK1 Regulates Skeletal Muscle Mass, Hypertrophic Signaling, and Metabolic Homeostasis in Male and Female Mice

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Targeted inactivation of TAK1 induces more rapid muscle atrophy in male mice compared to female mice. In addition, loss of TAK1 impairs mechanical overload–induced phosphorylation of p70S6K and rpS6, leading to blunted muscle hypertrophic growth. TAK1 inactivation also promotes lipid accumulation while reducing fatty acid metabolism in skeletal muscle ...
Meiricris Tomaz da Silva, Aniket S. Joshi, Anirban Roy, Troy A. Hornberger, Ashok Kumar   +4 more
wiley   +1 more source

Hepatic activating transcription factor 3 protects against systemic inflammation by attenuating lipotoxicity. [PDF]

Metabol Open
Hu C, Yang Q, Yu R, Hu S, Meng B, Xu Y.
europepmc   +1 more source

The E3 Ligase RNF8 Promotes Ubiquitination and Degradation of ChREBPα During Liver Stress Response

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
During MASH development, increasing hepatic stress signals, particularly a combination of lipotoxicity (palmitate) and inflammation (TNFα), trigger JNK, the key stress‐activated protein kinase. Activated JNK recruits RNF8, a stress‐induced E3 ligase, to promote ubiquitination and proteasomal degradation of the ChREBPα protein.
Yuee Zhao, Sujuan Wang, Jian Zhang, Sarah Cooke, Gary Zhang, Zifeng Zhao, Joon Oh, Xin Tong, Lei Yin   +8 more
wiley   +1 more source

The immunometabolic mechanisms and therapeutic targets of metabolic dysfunction-associated steatohepatitis. [PDF]

Front Med (Lausanne)
Yu J, Peng Y.
europepmc   +1 more source

MASLD: Lipotoxicity and Imaging Parallels from Liver Steatosis to Kidney Injury. [PDF]

Life (Basel)
Săndulescu SM, Ghiga DȘ, Tudorașcu DR, Săndulescu DL, Mită A, Urhuț MC, Taisescu CI.   +6 more
europepmc   +1 more source

Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of diabetic kidney disease (DKD). [PDF]

Cell Death Discov
Zheng Z, Li Y, Pan Y.
europepmc   +1 more source

Metabolic crossroads in insulin resistance: exploring lipid dysregulation and inflammation. [PDF]

Front Immunol
Saadati S, Godini R, Reddy A, Teede H, Mousa A.   +4 more
europepmc   +1 more source

Long-Chain Fatty Acids as Drivers of Neuroinflammation in Neurodegeneration: Mechanistic Links to Lipid Peroxidation, Ferroptosis, and Mitochondrial Dysfunction. [PDF]

Nutrients
Christodoulou RC, Lorentzen L, Eller D, Vassiliou E.   +3 more
europepmc   +1 more source

Mechanism of exercise-derived circulating exosomes as a target for sarcopenia management. [PDF]

Front Physiol
Wang X, Huang H, Chen J, Zhang Q, Yuan Z, Yin M, Peng C, Liu S.   +7 more
europepmc   +1 more source