Results 221 to 230 of about 28,679 (286)

Inhibition of STING alleviates lipotoxicity in viral-infected primary mouse hepatocytes and viral hepatitis-associated liver damage. [PDF]

Front Pharmacol
Zhang Y, Li Y, Qin Y, Liang S, Liu K, Liang X.   +5 more
europepmc   +1 more source

Mitochondrial DNA: A Key Alarmin Igniting the Inflammasome Fire in Health and Disease

Immunology, Volume 178, Issue 2, Page 218-230, June 2026.
This review illustrates how mitochondrial DNA, released under cellular stress, acts as a key alarmin that ignites innate immune sensors, particularly inflammasomes and the cGAS‐STING pathway. This paper details how this sustained “inflammasome fire” fuels the progression of diverse inflammatory diseases, including neurodegeneration and metabolic ...
Woo Hyun Park
wiley   +1 more source

Adipocyte Size, Overweight, and Insulin Resistance in Type 2 Diabetes Mellitus and the Impact of Weight Loss: A Systematic Review. [PDF]

Nutrients
Oshakbayev KP, Nabiyev AN, Durmanova AK, Kuttymuratov GM, Suleimenov TS, Bikhanov NA, Idrissov AS, Bazheneyeva GZ, Manekenova K, Akilzhanova AR, Dukenbayeva BA.   +10 more
europepmc   +1 more source

The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley   +1 more source

Insulin resistance spawns hypertriglyceridemia-induced acute pancreatitis and diabetic ketoacidosis: an evolving metabolic cascade. [PDF]

Cardiovasc Endocrinol Metab
Wu C, Tiwari A, Zlatopolsky M, Qaqish O, Harder WE, Blaceri S, Saad C, Kambhatla S, Kondur A.   +8 more
europepmc   +1 more source

High cholesterol absorption efficiency enhances proatherogenic properties of low‐density lipoprotein particles

Journal of Internal Medicine, Volume 299, Issue 6, Page 711-725, June 2026.
Abstract Background and Aims High cholesterol absorption efficiency is determined by genetic variation in small intestinal sterol transporters and affects one‐third of individuals. Their risk for atherosclerotic cardiovascular disease (ASCVD) is increased compared with low cholesterol absorbers, despite similar serum lipid concentrations.
Katariina Öörni, Lauri Äikäs, Maija Ruuth, Feven Tigistu‐Sahle, Reijo Käkelä, Ingmar Wester, Helena Gylling, Piia Simonen   +7 more
wiley   +1 more source

Plenary Abstracts Session & Oral Presentations

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Distinct Roles of Myeloid‐ and Hepatocyte‐PLA2G6 Deletion in Mice With Metabolic Dysfunction‐Associated Steatotic Liver Disease

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT Background and Aims Polymorphisms of group VIA calcium‐independent phospholipase A2 (iPLA2β or PLA2G6) are associated with Type‐2 diabetes, blood lipids and inflammation. Global deficiency in iPLA2β‐null mice elicited protection against hepatic steatosis but not hepatic inflammation after high‐fat diet (HFD) feeding.
Gang Li, Simone Staffer, Sabine Tuma‐Kellner, Uta Merle, Walee Chamulitrat   +4 more
wiley   +1 more source

Caveolin-1 deficiency improved glucose metabolism via modulation of β-cell autophagy in high-fat diet-fed mice. [PDF]

J Biol Chem
Zeng W, Cai N, Liu J, Liu K, Lin S, Yang X, Zeng L.   +6 more
europepmc   +1 more source

Systemic Inflammation and Peripheral T Cell Responses Associate With Hepatic Energy Metabolism in Recent‐Onset Type 1 Diabetes

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT People with type 1 diabetes feature lower concentrations of hepatic adenosine‐triphosphate (ATP) and inorganic phosphate (Pi), which further decline during the early course of disease. However, it is unknown whether inflammatory pathways are involved in the diabetes‐associated alterations of hepatic energy metabolism.
Jacqueline M. Ratter‐Rieck, Alexandra Zepina, Maximilian Huttasch, Yuliya Kupriyanova, Agnese Petrera, Sandra Trenkamp, Robert Wagner, Vera Schrauwen‐Hinderling, Christian Herder, Michael Roden, GDS group, M. Roden, H. Al‐Hasani, B. Belgardt, E. Lammert, G. Bönhof, G. Geerling, C. Herder, A. Icks, K. Jandeleit‐Dahm, O. Kuß, S. Schlesinger, V. Schrauwen‐Hinderling, J. Szendroedi, S. Trenkamp, R. Wagner   +25 more
wiley   +1 more source